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Gene: LRCH3 |
Gene summary for LRCH3 |
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Gene information | Species | Human | Gene symbol | LRCH3 | Gene ID | 84859 |
Gene name | leucine rich repeats and calponin homology domain containing 3 | |
Gene Alias | LRCH3 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B4DU23 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84859 | LRCH3 | CCI_1 | Human | Cervix | CC | 2.53e-04 | 5.96e-01 | 0.528 |
84859 | LRCH3 | CCI_2 | Human | Cervix | CC | 5.73e-12 | 1.15e+00 | 0.5249 |
84859 | LRCH3 | CCI_3 | Human | Cervix | CC | 5.83e-20 | 9.76e-01 | 0.516 |
84859 | LRCH3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.39e-05 | 5.55e-01 | -0.0811 |
84859 | LRCH3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-16 | 6.89e-01 | -0.1954 |
84859 | LRCH3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.96e-06 | 5.25e-01 | -0.059 |
84859 | LRCH3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.03e-04 | 5.39e-01 | 0.0588 |
84859 | LRCH3 | A002-C-010 | Human | Colorectum | FAP | 7.04e-03 | -1.22e-01 | 0.242 |
84859 | LRCH3 | A015-C-203 | Human | Colorectum | FAP | 2.93e-23 | -3.28e-01 | -0.1294 |
84859 | LRCH3 | A015-C-204 | Human | Colorectum | FAP | 1.98e-04 | -2.92e-01 | -0.0228 |
84859 | LRCH3 | A002-C-201 | Human | Colorectum | FAP | 1.73e-08 | -2.89e-01 | 0.0324 |
84859 | LRCH3 | A002-C-203 | Human | Colorectum | FAP | 6.94e-04 | -1.51e-01 | 0.2786 |
84859 | LRCH3 | A001-C-108 | Human | Colorectum | FAP | 1.49e-15 | -1.89e-01 | -0.0272 |
84859 | LRCH3 | A002-C-205 | Human | Colorectum | FAP | 2.05e-14 | -1.98e-01 | -0.1236 |
84859 | LRCH3 | A015-C-006 | Human | Colorectum | FAP | 1.15e-08 | -2.53e-01 | -0.0994 |
84859 | LRCH3 | A015-C-106 | Human | Colorectum | FAP | 1.30e-10 | -2.28e-01 | -0.0511 |
84859 | LRCH3 | A002-C-114 | Human | Colorectum | FAP | 1.71e-12 | -3.91e-01 | -0.1561 |
84859 | LRCH3 | A015-C-104 | Human | Colorectum | FAP | 2.86e-24 | -2.77e-01 | -0.1899 |
84859 | LRCH3 | A001-C-014 | Human | Colorectum | FAP | 8.32e-13 | -2.23e-01 | 0.0135 |
84859 | LRCH3 | A002-C-016 | Human | Colorectum | FAP | 8.92e-20 | -2.71e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRCH3 | SNV | Missense_Mutation | novel | c.293N>A | p.Pro98His | p.P98H | Q96II8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A1GO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
LRCH3 | SNV | Missense_Mutation | rs373640978 | c.665G>A | p.Arg222Gln | p.R222Q | Q96II8 | protein_coding | deleterious(0) | benign(0.095) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
LRCH3 | deletion | Frame_Shift_Del | novel | c.450_451delGT | p.Cys151SerfsTer84 | p.C151Sfs*84 | protein_coding | TCGA-EC-A24G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
LRCH3 | SNV | Missense_Mutation | rs773998276 | c.1184N>A | p.Gly395Glu | p.G395E | Q96II8 | protein_coding | tolerated(0.22) | benign(0.168) | TCGA-CC-A5UE-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
LRCH3 | SNV | Missense_Mutation | novel | c.838N>T | p.Ala280Ser | p.A280S | Q96II8 | protein_coding | tolerated(0.21) | benign(0.041) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD |
LRCH3 | SNV | Missense_Mutation | c.1176N>T | p.Gln392His | p.Q392H | Q96II8 | protein_coding | tolerated(0.05) | benign(0.012) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
LRCH3 | SNV | Missense_Mutation | c.1118N>G | p.Asp373Gly | p.D373G | Q96II8 | protein_coding | deleterious(0) | benign(0.132) | TCGA-50-5946-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
LRCH3 | SNV | Missense_Mutation | novel | c.869C>A | p.Pro290Gln | p.P290Q | Q96II8 | protein_coding | deleterious(0) | possibly_damaging(0.56) | TCGA-55-6981-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | chemo | CR |
LRCH3 | SNV | Missense_Mutation | c.1690N>T | p.His564Tyr | p.H564Y | Q96II8 | protein_coding | tolerated(0.45) | benign(0.404) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
LRCH3 | SNV | Missense_Mutation | rs777850185 | c.8N>T | p.Ala3Val | p.A3V | Q96II8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.917) | TCGA-69-7763-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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