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Gene: KPNA5 |
Gene summary for KPNA5 |
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Gene information | Species | Human | Gene symbol | KPNA5 | Gene ID | 3841 |
Gene name | karyopherin subunit alpha 5 | |
Gene Alias | IPOA6 | |
Cytomap | 6q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006606 | UniProtAcc | O15131 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3841 | KPNA5 | male-WTA | Human | Thyroid | PTC | 1.52e-10 | 2.79e-02 | 0.1037 |
3841 | KPNA5 | PTC01 | Human | Thyroid | PTC | 3.30e-06 | 4.80e-02 | 0.1899 |
3841 | KPNA5 | PTC04 | Human | Thyroid | PTC | 5.30e-12 | 1.37e-01 | 0.1927 |
3841 | KPNA5 | PTC05 | Human | Thyroid | PTC | 4.69e-02 | 3.13e-01 | 0.2065 |
3841 | KPNA5 | PTC06 | Human | Thyroid | PTC | 2.59e-20 | 3.15e-01 | 0.2057 |
3841 | KPNA5 | PTC07 | Human | Thyroid | PTC | 8.91e-24 | 2.70e-01 | 0.2044 |
3841 | KPNA5 | ATC09 | Human | Thyroid | ATC | 3.58e-03 | 5.12e-02 | 0.2871 |
3841 | KPNA5 | ATC12 | Human | Thyroid | ATC | 2.99e-05 | 6.40e-02 | 0.34 |
3841 | KPNA5 | ATC13 | Human | Thyroid | ATC | 3.33e-27 | 4.61e-01 | 0.34 |
3841 | KPNA5 | ATC1 | Human | Thyroid | ATC | 4.03e-02 | 5.05e-02 | 0.2878 |
3841 | KPNA5 | ATC2 | Human | Thyroid | ATC | 1.26e-04 | 1.94e-01 | 0.34 |
3841 | KPNA5 | ATC4 | Human | Thyroid | ATC | 4.13e-05 | 1.12e-01 | 0.34 |
3841 | KPNA5 | ATC5 | Human | Thyroid | ATC | 6.18e-33 | 5.04e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594112 | Thyroid | PTC | establishment of protein localization to organelle | 244/5968 | 422/18723 | 1.18e-28 | 4.97e-26 | 244 |
GO:0006913112 | Thyroid | PTC | nucleocytoplasmic transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
GO:0051169112 | Thyroid | PTC | nuclear transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
GO:0034504111 | Thyroid | PTC | protein localization to nucleus | 170/5968 | 290/18723 | 3.34e-21 | 6.38e-19 | 170 |
GO:0017038111 | Thyroid | PTC | protein import | 109/5968 | 206/18723 | 2.74e-10 | 8.96e-09 | 109 |
GO:005117017 | Thyroid | PTC | import into nucleus | 85/5968 | 159/18723 | 1.30e-08 | 3.08e-07 | 85 |
GO:000660616 | Thyroid | PTC | protein import into nucleus | 82/5968 | 155/18723 | 4.32e-08 | 9.27e-07 | 82 |
GO:007259429 | Thyroid | ATC | establishment of protein localization to organelle | 247/6293 | 422/18723 | 2.88e-26 | 1.40e-23 | 247 |
GO:003450423 | Thyroid | ATC | protein localization to nucleus | 175/6293 | 290/18723 | 6.23e-21 | 1.23e-18 | 175 |
GO:000691326 | Thyroid | ATC | nucleocytoplasmic transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
GO:005116926 | Thyroid | ATC | nuclear transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
GO:001703822 | Thyroid | ATC | protein import | 110/6293 | 206/18723 | 3.49e-09 | 8.09e-08 | 110 |
GO:005117018 | Thyroid | ATC | import into nucleus | 86/6293 | 159/18723 | 8.02e-08 | 1.40e-06 | 86 |
GO:000660617 | Thyroid | ATC | protein import into nucleus | 83/6293 | 155/18723 | 2.38e-07 | 3.70e-06 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KPNA5 | SNV | Missense_Mutation | c.728N>A | p.Gly243Asp | p.G243D | O15131 | protein_coding | deleterious(0.01) | benign(0.127) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KPNA5 | SNV | Missense_Mutation | c.344C>A | p.Pro115His | p.P115H | O15131 | protein_coding | tolerated(0.16) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KPNA5 | SNV | Missense_Mutation | c.8N>A | p.Ala3Asp | p.A3D | O15131 | protein_coding | tolerated(0.16) | benign(0.024) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KPNA5 | SNV | Missense_Mutation | novel | c.273N>A | p.Met91Ile | p.M91I | O15131 | protein_coding | tolerated(0.07) | probably_damaging(0.978) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KPNA5 | SNV | Missense_Mutation | c.1168C>T | p.Leu390Phe | p.L390F | O15131 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-D7-6822-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KPNA5 | insertion | In_Frame_Ins | novel | c.71_72insACA | p.Pro24_Gln25insHis | p.P24_Q25insH | O15131 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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