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Gene: KIF2A |
Gene summary for KIF2A |
Gene summary. |
Gene information | Species | Human | Gene symbol | KIF2A | Gene ID | 3796 |
Gene name | kinesin family member 2A | |
Gene Alias | CDCBM3 | |
Cytomap | 5q12.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O00139 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3796 | KIF2A | LZE4T | Human | Esophagus | ESCC | 3.16e-09 | 3.37e-01 | 0.0811 |
3796 | KIF2A | LZE7T | Human | Esophagus | ESCC | 3.57e-07 | 3.88e-01 | 0.0667 |
3796 | KIF2A | LZE8T | Human | Esophagus | ESCC | 3.60e-02 | 1.08e-01 | 0.067 |
3796 | KIF2A | LZE20T | Human | Esophagus | ESCC | 1.77e-03 | 1.37e-01 | 0.0662 |
3796 | KIF2A | LZE24T | Human | Esophagus | ESCC | 1.21e-11 | 3.92e-01 | 0.0596 |
3796 | KIF2A | P1T-E | Human | Esophagus | ESCC | 1.23e-12 | 6.07e-01 | 0.0875 |
3796 | KIF2A | P2T-E | Human | Esophagus | ESCC | 8.40e-86 | 1.45e+00 | 0.1177 |
3796 | KIF2A | P4T-E | Human | Esophagus | ESCC | 1.37e-20 | 4.87e-01 | 0.1323 |
3796 | KIF2A | P5T-E | Human | Esophagus | ESCC | 8.29e-13 | 2.73e-01 | 0.1327 |
3796 | KIF2A | P8T-E | Human | Esophagus | ESCC | 4.05e-29 | 3.93e-01 | 0.0889 |
3796 | KIF2A | P9T-E | Human | Esophagus | ESCC | 8.07e-14 | 2.53e-01 | 0.1131 |
3796 | KIF2A | P10T-E | Human | Esophagus | ESCC | 3.58e-25 | 4.37e-01 | 0.116 |
3796 | KIF2A | P11T-E | Human | Esophagus | ESCC | 1.96e-14 | 6.03e-01 | 0.1426 |
3796 | KIF2A | P12T-E | Human | Esophagus | ESCC | 1.32e-32 | 6.58e-01 | 0.1122 |
3796 | KIF2A | P15T-E | Human | Esophagus | ESCC | 4.54e-23 | 5.63e-01 | 0.1149 |
3796 | KIF2A | P16T-E | Human | Esophagus | ESCC | 3.94e-48 | 7.47e-01 | 0.1153 |
3796 | KIF2A | P17T-E | Human | Esophagus | ESCC | 1.01e-05 | 4.44e-01 | 0.1278 |
3796 | KIF2A | P19T-E | Human | Esophagus | ESCC | 6.26e-08 | 4.69e-01 | 0.1662 |
3796 | KIF2A | P20T-E | Human | Esophagus | ESCC | 3.20e-36 | 7.95e-01 | 0.1124 |
3796 | KIF2A | P21T-E | Human | Esophagus | ESCC | 1.28e-35 | 6.49e-01 | 0.1617 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
GO:009030715 | Esophagus | ESCC | mitotic spindle assembly | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
GO:00436245 | Esophagus | ESCC | cellular protein complex disassembly | 78/8552 | 136/18723 | 4.00e-03 | 1.62e-02 | 78 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:014001411 | Liver | HCC | mitotic nuclear division | 174/7958 | 287/18723 | 3.74e-10 | 1.23e-08 | 174 |
GO:003298411 | Liver | HCC | protein-containing complex disassembly | 138/7958 | 224/18723 | 5.59e-09 | 1.46e-07 | 138 |
GO:000705111 | Liver | HCC | spindle organization | 116/7958 | 184/18723 | 1.40e-08 | 3.40e-07 | 116 |
GO:000705211 | Liver | HCC | mitotic spindle organization | 80/7958 | 120/18723 | 7.43e-08 | 1.50e-06 | 80 |
GO:190285011 | Liver | HCC | microtubule cytoskeleton organization involved in mitosis | 93/7958 | 147/18723 | 2.91e-07 | 5.09e-06 | 93 |
GO:005122511 | Liver | HCC | spindle assembly | 75/7958 | 117/18723 | 1.92e-06 | 2.67e-05 | 75 |
GO:0048285 | Liver | HCC | organelle fission | 254/7958 | 488/18723 | 1.07e-05 | 1.23e-04 | 254 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF2A | SNV | Missense_Mutation | novel | c.586N>A | p.Glu196Lys | p.E196K | O00139 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
KIF2A | SNV | Missense_Mutation | novel | c.320C>T | p.Ser107Leu | p.S107L | O00139 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
KIF2A | SNV | Missense_Mutation | novel | c.1885N>T | p.Asp629Tyr | p.D629Y | O00139 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-33-AASB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIF2A | SNV | Missense_Mutation | c.362G>T | p.Ser121Ile | p.S121I | O00139 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KIF2A | SNV | Missense_Mutation | rs757038674 | c.173G>A | p.Ser58Asn | p.S58N | O00139 | protein_coding | tolerated(0.38) | benign(0.274) | TCGA-66-2744-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIF2A | SNV | Missense_Mutation | novel | c.680N>T | p.Cys227Phe | p.C227F | O00139 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-77-A5G1-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
KIF2A | deletion | Frame_Shift_Del | novel | c.1362_1368delTCTCATT | p.Leu455IlefsTer30 | p.L455Ifs*30 | O00139 | protein_coding | TCGA-68-A59J-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KIF2A | SNV | Missense_Mutation | c.86N>C | p.Val29Ala | p.V29A | O00139 | protein_coding | deleterious(0.01) | possibly_damaging(0.596) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
KIF2A | SNV | Missense_Mutation | c.269N>C | p.Lys90Thr | p.K90T | O00139 | protein_coding | tolerated(0.16) | benign(0.316) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
KIF2A | SNV | Missense_Mutation | c.1783N>A | p.Pro595Thr | p.P595T | O00139 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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