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Gene: KIAA1161 |
Gene summary for KIAA1161 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KIAA1161 | Gene ID | 57462 |
Gene name | myogenesis regulating glycosidase (putative) | |
Gene Alias | IBGC7 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q6NSJ0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57462 | KIAA1161 | HCC1_Meng | Human | Liver | HCC | 7.14e-15 | 4.64e-02 | 0.0246 |
57462 | KIAA1161 | HCC2_Meng | Human | Liver | HCC | 1.05e-05 | 5.28e-02 | 0.0107 |
57462 | KIAA1161 | HCC1 | Human | Liver | HCC | 6.95e-06 | 2.08e+00 | 0.5336 |
57462 | KIAA1161 | HCC2 | Human | Liver | HCC | 6.44e-09 | 2.19e+00 | 0.5341 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1161 | SNV | Missense_Mutation | novel | c.77A>C | p.Asn26Thr | p.N26T | Q6NSJ0 | protein_coding | tolerated_low_confidence(0.6) | benign(0) | TCGA-CN-5365-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
KIAA1161 | SNV | Missense_Mutation | novel | c.1863G>T | p.Glu621Asp | p.E621D | Q6NSJ0 | protein_coding | tolerated(0.13) | benign(0.194) | TCGA-CN-6989-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
KIAA1161 | SNV | Missense_Mutation | novel | c.1888G>C | p.Gly630Arg | p.G630R | Q6NSJ0 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA1161 | SNV | Missense_Mutation | novel | c.2058G>T | p.Lys686Asn | p.K686N | Q6NSJ0 | protein_coding | deleterious(0.04) | probably_damaging(0.959) | TCGA-CR-7389-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | CR |
KIAA1161 | SNV | Missense_Mutation | novel | c.2087N>G | p.Leu696Arg | p.L696R | Q6NSJ0 | protein_coding | tolerated(0.23) | possibly_damaging(0.801) | TCGA-CV-5978-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KIAA1161 | SNV | Missense_Mutation | rs764275725 | c.709N>G | p.Ile237Val | p.I237V | Q6NSJ0 | protein_coding | tolerated(0.49) | benign(0.279) | TCGA-CV-A6JN-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA1161 | SNV | Missense_Mutation | novel | c.1514N>C | p.Val505Ala | p.V505A | Q6NSJ0 | protein_coding | tolerated(0.39) | benign(0.214) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA1161 | SNV | Missense_Mutation | novel | c.568N>A | p.Glu190Lys | p.E190K | Q6NSJ0 | protein_coding | tolerated(0.06) | possibly_damaging(0.743) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
KIAA1161 | SNV | Missense_Mutation | c.941N>C | p.Arg314Pro | p.R314P | Q6NSJ0 | protein_coding | deleterious(0.01) | possibly_damaging(0.687) | TCGA-J4-A67Q-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD | |
KIAA1161 | deletion | Frame_Shift_Del | novel | c.977_1010delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Arg326ProfsTer97 | p.R326Pfs*97 | Q6NSJ0 | protein_coding | TCGA-J9-A8CM-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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