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Gene: KIAA0907 |
Gene summary for KIAA0907 |
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Gene information | Species | Human | Gene symbol | KIAA0907 | Gene ID | 22889 |
Gene name | KH domain containing 4, pre-mRNA splicing factor | |
Gene Alias | BLOM7 | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0000245 | UniProtAcc | Q7Z7F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22889 | KIAA0907 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.11e-46 | 8.18e-01 | 0.294 |
22889 | KIAA0907 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.28e-10 | 7.66e-01 | 0.3487 |
22889 | KIAA0907 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.31e-25 | 6.23e-01 | 0.281 |
22889 | KIAA0907 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.45e-42 | 8.36e-01 | 0.3859 |
22889 | KIAA0907 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.57e-07 | 2.95e-01 | 0.2585 |
22889 | KIAA0907 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.93e-21 | 4.16e-01 | 0.3005 |
22889 | KIAA0907 | P1T-E | Human | Esophagus | ESCC | 6.60e-11 | 5.93e-01 | 0.0875 |
22889 | KIAA0907 | P2T-E | Human | Esophagus | ESCC | 1.84e-18 | 4.14e-01 | 0.1177 |
22889 | KIAA0907 | P4T-E | Human | Esophagus | ESCC | 8.61e-22 | 3.34e-01 | 0.1323 |
22889 | KIAA0907 | P5T-E | Human | Esophagus | ESCC | 1.65e-21 | 4.09e-01 | 0.1327 |
22889 | KIAA0907 | P8T-E | Human | Esophagus | ESCC | 9.29e-21 | 3.70e-01 | 0.0889 |
22889 | KIAA0907 | P9T-E | Human | Esophagus | ESCC | 1.80e-10 | 3.21e-01 | 0.1131 |
22889 | KIAA0907 | P10T-E | Human | Esophagus | ESCC | 7.42e-37 | 7.41e-01 | 0.116 |
22889 | KIAA0907 | P11T-E | Human | Esophagus | ESCC | 5.61e-09 | 6.86e-01 | 0.1426 |
22889 | KIAA0907 | P12T-E | Human | Esophagus | ESCC | 4.34e-19 | 3.84e-01 | 0.1122 |
22889 | KIAA0907 | P15T-E | Human | Esophagus | ESCC | 1.32e-19 | 6.02e-01 | 0.1149 |
22889 | KIAA0907 | P16T-E | Human | Esophagus | ESCC | 2.33e-10 | 3.60e-01 | 0.1153 |
22889 | KIAA0907 | P17T-E | Human | Esophagus | ESCC | 2.37e-07 | 1.84e-01 | 0.1278 |
22889 | KIAA0907 | P20T-E | Human | Esophagus | ESCC | 1.29e-14 | 4.49e-01 | 0.1124 |
22889 | KIAA0907 | P21T-E | Human | Esophagus | ESCC | 1.62e-12 | 2.53e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0907 | SNV | Missense_Mutation | novel | c.281C>G | p.Thr94Ser | p.T94S | Q7Z7F0 | protein_coding | tolerated(0.59) | benign(0.001) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA0907 | SNV | Missense_Mutation | c.262N>T | p.Ala88Ser | p.A88S | Q7Z7F0 | protein_coding | tolerated(0.6) | benign(0.026) | TCGA-22-4593-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0907 | SNV | Missense_Mutation | novel | c.770N>C | p.Cys257Ser | p.C257S | Q7Z7F0 | protein_coding | tolerated(0.63) | benign(0.152) | TCGA-63-7021-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | PD |
KIAA0907 | SNV | Missense_Mutation | novel | c.620A>C | p.Gln207Pro | p.Q207P | Q7Z7F0 | protein_coding | tolerated(0.16) | possibly_damaging(0.862) | TCGA-96-A4JK-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR |
KIAA0907 | SNV | Missense_Mutation | novel | c.515N>T | p.Asp172Val | p.D172V | Q7Z7F0 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-NC-A5HM-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA0907 | SNV | Missense_Mutation | novel | c.1129C>T | p.Pro377Ser | p.P377S | Q7Z7F0 | protein_coding | tolerated(0.13) | probably_damaging(0.996) | TCGA-NK-A7XE-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
KIAA0907 | SNV | Missense_Mutation | novel | c.937G>A | p.Glu313Lys | p.E313K | Q7Z7F0 | protein_coding | deleterious(0.01) | benign(0.43) | TCGA-CR-6484-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
KIAA0907 | SNV | Missense_Mutation | novel | c.1361N>G | p.Pro454Arg | p.P454R | Q7Z7F0 | protein_coding | tolerated(0.06) | benign(0.05) | TCGA-CV-7099-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA0907 | SNV | Missense_Mutation | novel | c.194A>G | p.Lys65Arg | p.K65R | Q7Z7F0 | protein_coding | tolerated(0.11) | possibly_damaging(0.765) | TCGA-CV-7252-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KIAA0907 | SNV | Missense_Mutation | novel | c.761N>T | p.Gly254Val | p.G254V | Q7Z7F0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-7253-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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