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Gene: KHNYN |
Gene summary for KHNYN |
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Gene information | Species | Human | Gene symbol | KHNYN | Gene ID | 23351 |
Gene name | KH and NYN domain containing | |
Gene Alias | KIAA0323 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O15037 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23351 | KHNYN | LZE8T | Human | Esophagus | ESCC | 4.68e-04 | 1.08e-01 | 0.067 |
23351 | KHNYN | LZE24T | Human | Esophagus | ESCC | 5.40e-11 | 2.33e-01 | 0.0596 |
23351 | KHNYN | P2T-E | Human | Esophagus | ESCC | 1.03e-11 | 1.88e-01 | 0.1177 |
23351 | KHNYN | P5T-E | Human | Esophagus | ESCC | 6.82e-07 | 3.48e-02 | 0.1327 |
23351 | KHNYN | P8T-E | Human | Esophagus | ESCC | 1.34e-15 | 2.43e-01 | 0.0889 |
23351 | KHNYN | P9T-E | Human | Esophagus | ESCC | 4.77e-04 | 7.67e-02 | 0.1131 |
23351 | KHNYN | P10T-E | Human | Esophagus | ESCC | 9.17e-12 | 2.06e-01 | 0.116 |
23351 | KHNYN | P11T-E | Human | Esophagus | ESCC | 6.06e-05 | 1.49e-01 | 0.1426 |
23351 | KHNYN | P12T-E | Human | Esophagus | ESCC | 5.04e-17 | 2.63e-01 | 0.1122 |
23351 | KHNYN | P15T-E | Human | Esophagus | ESCC | 1.86e-20 | 3.37e-01 | 0.1149 |
23351 | KHNYN | P16T-E | Human | Esophagus | ESCC | 1.07e-02 | 2.68e-02 | 0.1153 |
23351 | KHNYN | P17T-E | Human | Esophagus | ESCC | 7.45e-05 | 2.10e-01 | 0.1278 |
23351 | KHNYN | P20T-E | Human | Esophagus | ESCC | 1.22e-03 | 4.92e-02 | 0.1124 |
23351 | KHNYN | P21T-E | Human | Esophagus | ESCC | 1.03e-05 | 1.32e-01 | 0.1617 |
23351 | KHNYN | P22T-E | Human | Esophagus | ESCC | 2.03e-11 | 1.15e-01 | 0.1236 |
23351 | KHNYN | P23T-E | Human | Esophagus | ESCC | 6.11e-07 | 1.19e-01 | 0.108 |
23351 | KHNYN | P26T-E | Human | Esophagus | ESCC | 4.85e-07 | 8.73e-02 | 0.1276 |
23351 | KHNYN | P27T-E | Human | Esophagus | ESCC | 4.60e-10 | 1.30e-01 | 0.1055 |
23351 | KHNYN | P28T-E | Human | Esophagus | ESCC | 2.20e-14 | 3.32e-01 | 0.1149 |
23351 | KHNYN | P30T-E | Human | Esophagus | ESCC | 1.47e-07 | 2.85e-01 | 0.137 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KHNYN | SNV | Missense_Mutation | c.416C>T | p.Ala139Val | p.A139V | O15037 | protein_coding | tolerated(1) | benign(0) | TCGA-BJ-A2NA-01 | Thyroid | thyroid carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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