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Gene: KDM1B |
Gene summary for KDM1B |
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Gene information | Species | Human | Gene symbol | KDM1B | Gene ID | 221656 |
Gene name | lysine demethylase 1B | |
Gene Alias | AOF1 | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8NB78 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221656 | KDM1B | LZE7T | Human | Esophagus | ESCC | 9.31e-05 | 2.38e-01 | 0.0667 |
221656 | KDM1B | LZE24T | Human | Esophagus | ESCC | 1.20e-09 | 1.56e-01 | 0.0596 |
221656 | KDM1B | P1T-E | Human | Esophagus | ESCC | 1.01e-03 | 1.56e-01 | 0.0875 |
221656 | KDM1B | P2T-E | Human | Esophagus | ESCC | 1.31e-16 | 2.96e-01 | 0.1177 |
221656 | KDM1B | P4T-E | Human | Esophagus | ESCC | 2.50e-12 | 1.74e-01 | 0.1323 |
221656 | KDM1B | P5T-E | Human | Esophagus | ESCC | 5.15e-04 | 8.47e-02 | 0.1327 |
221656 | KDM1B | P8T-E | Human | Esophagus | ESCC | 6.32e-03 | 3.57e-02 | 0.0889 |
221656 | KDM1B | P9T-E | Human | Esophagus | ESCC | 5.15e-05 | 1.47e-01 | 0.1131 |
221656 | KDM1B | P10T-E | Human | Esophagus | ESCC | 1.00e-14 | 2.20e-01 | 0.116 |
221656 | KDM1B | P11T-E | Human | Esophagus | ESCC | 2.30e-07 | 2.51e-01 | 0.1426 |
221656 | KDM1B | P12T-E | Human | Esophagus | ESCC | 3.25e-06 | 1.29e-01 | 0.1122 |
221656 | KDM1B | P15T-E | Human | Esophagus | ESCC | 4.13e-10 | 1.91e-01 | 0.1149 |
221656 | KDM1B | P16T-E | Human | Esophagus | ESCC | 2.05e-12 | 1.92e-01 | 0.1153 |
221656 | KDM1B | P17T-E | Human | Esophagus | ESCC | 1.11e-02 | 1.78e-01 | 0.1278 |
221656 | KDM1B | P19T-E | Human | Esophagus | ESCC | 8.28e-04 | 2.85e-01 | 0.1662 |
221656 | KDM1B | P20T-E | Human | Esophagus | ESCC | 1.76e-10 | 1.73e-01 | 0.1124 |
221656 | KDM1B | P21T-E | Human | Esophagus | ESCC | 1.58e-28 | 5.07e-01 | 0.1617 |
221656 | KDM1B | P22T-E | Human | Esophagus | ESCC | 9.70e-13 | 9.48e-02 | 0.1236 |
221656 | KDM1B | P23T-E | Human | Esophagus | ESCC | 1.57e-08 | 1.99e-01 | 0.108 |
221656 | KDM1B | P24T-E | Human | Esophagus | ESCC | 3.02e-07 | 1.47e-01 | 0.1287 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00400295 | Esophagus | ESCC | regulation of gene expression, epigenetic | 74/8552 | 105/18723 | 2.24e-07 | 3.42e-06 | 74 |
GO:00064824 | Esophagus | ESCC | protein demethylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00082144 | Esophagus | ESCC | protein dealkylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00165773 | Esophagus | ESCC | histone demethylation | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:00700763 | Esophagus | ESCC | histone lysine demethylation | 20/8552 | 28/18723 | 5.23e-03 | 1.97e-02 | 20 |
GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDM1B | SNV | Missense_Mutation | c.417N>T | p.Trp139Cys | p.W139C | Q8NB78 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
KDM1B | SNV | Missense_Mutation | rs775814508 | c.1765N>A | p.Ala589Thr | p.A589T | Q8NB78 | protein_coding | deleterious_low_confidence(0.02) | benign(0.018) | TCGA-55-7574-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
KDM1B | SNV | Missense_Mutation | c.1064N>T | p.Ala355Val | p.A355V | Q8NB78 | protein_coding | tolerated(0.08) | probably_damaging(0.96) | TCGA-22-1011-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KDM1B | SNV | Missense_Mutation | c.1157A>C | p.Tyr386Ser | p.Y386S | Q8NB78 | protein_coding | deleterious(0.02) | benign(0.113) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KDM1B | SNV | Missense_Mutation | c.1203G>T | p.Gln401His | p.Q401H | Q8NB78 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-66-2755-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KDM1B | SNV | Missense_Mutation | novel | c.952A>T | p.Met318Leu | p.M318L | Q8NB78 | protein_coding | tolerated_low_confidence(0.12) | possibly_damaging(0.833) | TCGA-77-8150-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
KDM1B | SNV | Missense_Mutation | novel | c.302N>C | p.Arg101Thr | p.R101T | Q8NB78 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KDM1B | deletion | Frame_Shift_Del | c.1723delN | p.Ala576HisfsTer3 | p.A576Hfs*3 | Q8NB78 | protein_coding | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response | |||
KDM1B | insertion | Frame_Shift_Ins | novel | c.1023_1024insG | p.Leu342AlafsTer11 | p.L342Afs*11 | Q8NB78 | protein_coding | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
KDM1B | SNV | Missense_Mutation | novel | c.559C>A | p.Leu187Ile | p.L187I | Q8NB78 | protein_coding | tolerated(0.45) | benign(0.023) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
221656 | KDM1B | DRUGGABLE GENOME, TRANSCRIPTION FACTOR BINDING, ENZYME | Tarnylcypromine derivative 3 | |||
221656 | KDM1B | DRUGGABLE GENOME, TRANSCRIPTION FACTOR BINDING, ENZYME | PMID27019002-Compound-48 | |||
221656 | KDM1B | DRUGGABLE GENOME, TRANSCRIPTION FACTOR BINDING, ENZYME | PMID27019002-Compound-47 | |||
221656 | KDM1B | DRUGGABLE GENOME, TRANSCRIPTION FACTOR BINDING, ENZYME | PMID27019002-Compound-46 | |||
221656 | KDM1B | DRUGGABLE GENOME, TRANSCRIPTION FACTOR BINDING, ENZYME | Tarnylcypromine derivative 2 |
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