|
Gene: KDELC1 |
Gene summary for KDELC1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KDELC1 | Gene ID | 79070 |
Gene name | protein O-glucosyltransferase 2 | |
Gene Alias | EP58 | |
Cytomap | 13q33.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q6UW63 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79070 | KDELC1 | P2T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.72e-01 | 0.1177 |
79070 | KDELC1 | P4T-E | Human | Esophagus | ESCC | 6.27e-06 | 1.54e-01 | 0.1323 |
79070 | KDELC1 | P10T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.68e-01 | 0.116 |
79070 | KDELC1 | P11T-E | Human | Esophagus | ESCC | 6.74e-09 | 3.60e-01 | 0.1426 |
79070 | KDELC1 | P12T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.39e-01 | 0.1122 |
79070 | KDELC1 | P16T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.27e-01 | 0.1153 |
79070 | KDELC1 | P21T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.09e-01 | 0.1617 |
79070 | KDELC1 | P22T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.51e-01 | 0.1236 |
79070 | KDELC1 | P24T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.34e-01 | 0.1287 |
79070 | KDELC1 | P26T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.60e-01 | 0.1276 |
79070 | KDELC1 | P30T-E | Human | Esophagus | ESCC | 1.02e-02 | 1.31e-01 | 0.137 |
79070 | KDELC1 | P31T-E | Human | Esophagus | ESCC | 3.50e-02 | 5.71e-02 | 0.1251 |
79070 | KDELC1 | P32T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.82e-01 | 0.1666 |
79070 | KDELC1 | P37T-E | Human | Esophagus | ESCC | 4.27e-06 | 1.52e-01 | 0.1371 |
79070 | KDELC1 | P42T-E | Human | Esophagus | ESCC | 2.93e-03 | 1.15e-01 | 0.1175 |
79070 | KDELC1 | P44T-E | Human | Esophagus | ESCC | 6.93e-04 | 1.71e-01 | 0.1096 |
79070 | KDELC1 | P52T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.20e-01 | 0.1555 |
79070 | KDELC1 | P56T-E | Human | Esophagus | ESCC | 3.89e-06 | 5.28e-01 | 0.1613 |
79070 | KDELC1 | P61T-E | Human | Esophagus | ESCC | 1.48e-02 | 8.96e-02 | 0.099 |
79070 | KDELC1 | P62T-E | Human | Esophagus | ESCC | 2.41e-07 | 1.62e-01 | 0.1302 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDELC1 | deletion | Frame_Shift_Del | novel | c.1071delN | p.Phe357LeufsTer10 | p.F357Lfs*10 | Q6UW63 | protein_coding | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KDELC1 | deletion | Frame_Shift_Del | c.731delN | p.Lys244ArgfsTer23 | p.K244Rfs*23 | Q6UW63 | protein_coding | TCGA-B5-A0K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD | |||
KDELC1 | SNV | Missense_Mutation | novel | c.1174N>C | p.Ser392Pro | p.S392P | Q6UW63 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KDELC1 | SNV | Missense_Mutation | novel | c.493N>T | p.Ala165Ser | p.A165S | Q6UW63 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KDELC1 | SNV | Missense_Mutation | c.1147G>A | p.Gly383Ser | p.G383S | Q6UW63 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
KDELC1 | SNV | Missense_Mutation | c.926N>T | p.Gly309Val | p.G309V | Q6UW63 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KDELC1 | SNV | Missense_Mutation | c.948N>T | p.Arg316Ser | p.R316S | Q6UW63 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
KDELC1 | SNV | Missense_Mutation | c.861N>T | p.Met287Ile | p.M287I | Q6UW63 | protein_coding | tolerated(0.13) | benign(0.027) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KDELC1 | SNV | Missense_Mutation | novel | c.115N>A | p.Leu39Ile | p.L39I | Q6UW63 | protein_coding | deleterious(0) | benign(0.342) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
KDELC1 | SNV | Missense_Mutation | novel | c.1373A>G | p.Lys458Arg | p.K458R | Q6UW63 | protein_coding | tolerated(0.62) | benign(0.042) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |