Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8850 | KAT2B | 048752_1579-all-cells | Human | Prostate | BPH | 4.30e-04 | 2.05e-01 | 0.1008 |
8850 | KAT2B | 052095_1628-all-cells | Human | Prostate | BPH | 9.24e-07 | 2.72e-01 | 0.1032 |
8850 | KAT2B | 052099_1652-all-cells | Human | Prostate | BPH | 1.39e-08 | 2.71e-01 | 0.1038 |
8850 | KAT2B | Dong_P3 | Human | Prostate | Tumor | 6.82e-09 | 1.50e-01 | 0.0278 |
8850 | KAT2B | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 6.37e-12 | 5.69e-01 | 0.1633 |
8850 | KAT2B | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.30e-11 | 5.42e-01 | 0.1608 |
8850 | KAT2B | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 3.01e-05 | 4.30e-01 | 0.1604 |
8850 | KAT2B | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 6.94e-07 | 4.54e-01 | 0.1621 |
8850 | KAT2B | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 4.81e-05 | 6.29e-01 | 0.1619 |
8850 | KAT2B | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 1.92e-02 | 5.54e-01 | 0.159 |
8850 | KAT2B | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.18e-03 | 3.56e-01 | 0.1602 |
8850 | KAT2B | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 4.56e-05 | 5.68e-01 | 0.1608 |
8850 | KAT2B | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.51e-05 | 5.66e-01 | 0.1622 |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261318 | Prostate | BPH | ribonucleoprotein complex biogenesis | 150/3107 | 463/18723 | 2.18e-17 | 5.62e-15 | 150 |
GO:004851110 | Prostate | BPH | rhythmic process | 96/3107 | 298/18723 | 1.88e-11 | 1.31e-09 | 96 |
GO:004593618 | Prostate | BPH | negative regulation of phosphate metabolic process | 124/3107 | 441/18723 | 5.95e-10 | 2.90e-08 | 124 |
GO:001056318 | Prostate | BPH | negative regulation of phosphorus metabolic process | 124/3107 | 442/18723 | 6.94e-10 | 3.25e-08 | 124 |
GO:004232617 | Prostate | BPH | negative regulation of phosphorylation | 110/3107 | 385/18723 | 2.08e-09 | 8.35e-08 | 110 |
GO:190165310 | Prostate | BPH | cellular response to peptide | 104/3107 | 359/18723 | 2.51e-09 | 1.00e-07 | 104 |
GO:004225418 | Prostate | BPH | ribosome biogenesis | 90/3107 | 299/18723 | 3.82e-09 | 1.44e-07 | 90 |
GO:000193317 | Prostate | BPH | negative regulation of protein phosphorylation | 97/3107 | 342/18723 | 2.74e-08 | 8.11e-07 | 97 |
GO:00165706 | Prostate | BPH | histone modification | 120/3107 | 463/18723 | 1.73e-07 | 3.89e-06 | 120 |
GO:005134818 | Prostate | BPH | negative regulation of transferase activity | 78/3107 | 268/18723 | 1.94e-07 | 4.29e-06 | 78 |
GO:004343417 | Prostate | BPH | response to peptide hormone | 109/3107 | 414/18723 | 2.73e-07 | 5.91e-06 | 109 |
GO:00719009 | Prostate | BPH | regulation of protein serine/threonine kinase activity | 97/3107 | 359/18723 | 3.42e-07 | 7.23e-06 | 97 |
GO:00713759 | Prostate | BPH | cellular response to peptide hormone stimulus | 82/3107 | 290/18723 | 3.65e-07 | 7.65e-06 | 82 |
GO:003286910 | Prostate | BPH | cellular response to insulin stimulus | 61/3107 | 203/18723 | 1.26e-06 | 2.20e-05 | 61 |
GO:00516049 | Prostate | BPH | protein maturation | 80/3107 | 294/18723 | 2.64e-06 | 4.23e-05 | 80 |
GO:000646916 | Prostate | BPH | negative regulation of protein kinase activity | 62/3107 | 212/18723 | 2.81e-06 | 4.45e-05 | 62 |
GO:003286810 | Prostate | BPH | response to insulin | 73/3107 | 264/18723 | 3.80e-06 | 5.83e-05 | 73 |
GO:003367315 | Prostate | BPH | negative regulation of kinase activity | 67/3107 | 237/18723 | 4.15e-06 | 6.25e-05 | 67 |
GO:00182055 | Prostate | BPH | peptidyl-lysine modification | 96/3107 | 376/18723 | 5.70e-06 | 8.39e-05 | 96 |
GO:19040292 | Prostate | BPH | regulation of cyclin-dependent protein kinase activity | 34/3107 | 98/18723 | 1.00e-05 | 1.39e-04 | 34 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KAT2B | SNV | Missense_Mutation | novel | c.1374N>A | p.Met458Ile | p.M458I | Q92831 | protein_coding | tolerated(0.25) | benign(0.041) | TCGA-EC-A1QX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
KAT2B | SNV | Missense_Mutation | novel | c.2163N>T | p.Glu721Asp | p.E721D | Q92831 | protein_coding | tolerated(0.09) | possibly_damaging(0.536) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KAT2B | SNV | Missense_Mutation | rs778860966 | c.904N>A | p.Glu302Lys | p.E302K | Q92831 | protein_coding | tolerated(0.12) | possibly_damaging(0.698) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KAT2B | SNV | Missense_Mutation | novel | c.1974N>C | p.Glu658Asp | p.E658D | Q92831 | protein_coding | tolerated(0.08) | probably_damaging(0.916) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
KAT2B | SNV | Missense_Mutation | novel | c.806N>T | p.Arg269Leu | p.R269L | Q92831 | protein_coding | tolerated(0.12) | benign(0.069) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KAT2B | SNV | Missense_Mutation | rs202132144 | c.1016N>A | p.Arg339Gln | p.R339Q | Q92831 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KAT2B | SNV | Missense_Mutation | | c.1492G>A | p.Val498Met | p.V498M | Q92831 | protein_coding | deleterious(0.04) | possibly_damaging(0.736) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
KAT2B | SNV | Missense_Mutation | novel | c.1429N>A | p.Ala477Thr | p.A477T | Q92831 | protein_coding | tolerated(0.21) | benign(0.04) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KAT2B | insertion | Frame_Shift_Ins | novel | c.1618_1619insTTCTAATAAGATACAC | p.Asp540ValfsTer16 | p.D540Vfs*16 | Q92831 | protein_coding | | | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
KAT2B | deletion | Frame_Shift_Del | | c.2414delC | p.Pro805LeufsTer25 | p.P805Lfs*25 | Q92831 | protein_coding | | | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |