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Gene: JRKL |
Gene summary for JRKL |
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Gene information | Species | Human | Gene symbol | JRKL | Gene ID | 8690 |
Gene name | JRK like | |
Gene Alias | HHMJG | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q9Y4A0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8690 | JRKL | HCC1 | Human | Liver | HCC | 3.35e-03 | 2.23e+00 | 0.5336 |
8690 | JRKL | HCC2 | Human | Liver | HCC | 7.10e-03 | 1.54e+00 | 0.5341 |
8690 | JRKL | S029 | Human | Liver | HCC | 7.26e-03 | 1.47e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JRKL | SNV | Missense_Mutation | c.1494N>T | p.Met498Ile | p.M498I | Q9Y4A0 | protein_coding | tolerated(0.21) | benign(0) | TCGA-44-6779-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | taxol | PD | |
JRKL | SNV | Missense_Mutation | c.1165N>T | p.Leu389Phe | p.L389F | Q9Y4A0 | protein_coding | tolerated(0.65) | benign(0) | TCGA-55-8085-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
JRKL | SNV | Missense_Mutation | c.1054N>T | p.Asp352Tyr | p.D352Y | Q9Y4A0 | protein_coding | deleterious(0.02) | probably_damaging(0.93) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
JRKL | SNV | Missense_Mutation | rs148141652 | c.1342G>A | p.Glu448Lys | p.E448K | Q9Y4A0 | protein_coding | deleterious(0.03) | benign(0.335) | TCGA-CV-A460-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
JRKL | SNV | Missense_Mutation | novel | c.128G>T | p.Arg43Leu | p.R43L | Q9Y4A0 | protein_coding | tolerated(0.18) | probably_damaging(0.999) | TCGA-CX-7085-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
JRKL | SNV | Missense_Mutation | novel | c.1409N>G | p.Leu470Arg | p.L470R | Q9Y4A0 | protein_coding | tolerated(0.11) | possibly_damaging(0.693) | TCGA-D6-6823-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
JRKL | SNV | Missense_Mutation | c.1069N>C | p.Trp357Arg | p.W357R | Q9Y4A0 | protein_coding | tolerated(0.8) | probably_damaging(0.948) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
JRKL | SNV | Missense_Mutation | rs373707997 | c.1519N>T | p.Arg507Cys | p.R507C | Q9Y4A0 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-VQ-A8P3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
JRKL | deletion | In_Frame_Del | novel | c.1057_1059delNNN | p.Leu353del | p.L353del | Q9Y4A0 | protein_coding | TCGA-HU-A4GY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
JRKL | SNV | Missense_Mutation | novel | c.549G>C | p.Trp183Cys | p.W183C | Q9Y4A0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EL-A3ZR-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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