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Gene: IQCB1 |
Gene summary for IQCB1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | IQCB1 | Gene ID | 9657 |
Gene name | IQ motif containing B1 | |
Gene Alias | NPHP5 | |
Cytomap | 3q13.33 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q15051 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9657 | IQCB1 | CCI_1 | Human | Cervix | CC | 1.29e-07 | 7.86e-01 | 0.528 |
9657 | IQCB1 | CCI_2 | Human | Cervix | CC | 1.70e-11 | 1.23e+00 | 0.5249 |
9657 | IQCB1 | CCI_3 | Human | Cervix | CC | 1.20e-22 | 1.37e+00 | 0.516 |
9657 | IQCB1 | LZE2T | Human | Esophagus | ESCC | 3.01e-03 | 3.92e-01 | 0.082 |
9657 | IQCB1 | LZE4T | Human | Esophagus | ESCC | 3.04e-14 | 4.25e-01 | 0.0811 |
9657 | IQCB1 | LZE7T | Human | Esophagus | ESCC | 1.47e-12 | 5.99e-01 | 0.0667 |
9657 | IQCB1 | LZE8T | Human | Esophagus | ESCC | 1.27e-05 | 1.92e-01 | 0.067 |
9657 | IQCB1 | LZE20T | Human | Esophagus | ESCC | 1.39e-10 | 1.98e-01 | 0.0662 |
9657 | IQCB1 | LZE22T | Human | Esophagus | ESCC | 3.63e-02 | 3.67e-01 | 0.068 |
9657 | IQCB1 | LZE24T | Human | Esophagus | ESCC | 1.58e-19 | 4.93e-01 | 0.0596 |
9657 | IQCB1 | P1T-E | Human | Esophagus | ESCC | 4.58e-12 | 4.82e-01 | 0.0875 |
9657 | IQCB1 | P2T-E | Human | Esophagus | ESCC | 4.12e-25 | 3.68e-01 | 0.1177 |
9657 | IQCB1 | P4T-E | Human | Esophagus | ESCC | 1.01e-21 | 3.64e-01 | 0.1323 |
9657 | IQCB1 | P5T-E | Human | Esophagus | ESCC | 7.51e-25 | 4.59e-01 | 0.1327 |
9657 | IQCB1 | P8T-E | Human | Esophagus | ESCC | 1.02e-35 | 7.04e-01 | 0.0889 |
9657 | IQCB1 | P9T-E | Human | Esophagus | ESCC | 7.37e-15 | 3.11e-01 | 0.1131 |
9657 | IQCB1 | P10T-E | Human | Esophagus | ESCC | 4.20e-29 | 6.16e-01 | 0.116 |
9657 | IQCB1 | P11T-E | Human | Esophagus | ESCC | 6.49e-18 | 5.68e-01 | 0.1426 |
9657 | IQCB1 | P12T-E | Human | Esophagus | ESCC | 2.69e-18 | 2.33e-01 | 0.1122 |
9657 | IQCB1 | P15T-E | Human | Esophagus | ESCC | 1.10e-27 | 5.09e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
GO:00018957 | Cervix | CC | retina homeostasis | 19/2311 | 79/18723 | 2.94e-03 | 1.94e-02 | 19 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IQCB1 | SNV | Missense_Mutation | novel | c.984N>G | p.Phe328Leu | p.F328L | Q15051 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-UF-A7JT-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
IQCB1 | insertion | Frame_Shift_Ins | novel | c.651_652insTTTT | p.Leu218PhefsTer7 | p.L218Ffs*7 | Q15051 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
IQCB1 | insertion | Frame_Shift_Ins | novel | c.650_651insTAAAA | p.Lys217AsnfsTer12 | p.K217Nfs*12 | Q15051 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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