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Gene: IPPK |
Gene summary for IPPK |
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Gene information | Species | Human | Gene symbol | IPPK | Gene ID | 64768 |
Gene name | inositol-pentakisphosphate 2-kinase | |
Gene Alias | C9orf12 | |
Cytomap | 9q22.31 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q9H8X2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64768 | IPPK | CCI_1 | Human | Cervix | CC | 8.18e-06 | 4.98e-01 | 0.528 |
64768 | IPPK | CCI_2 | Human | Cervix | CC | 7.87e-09 | 6.87e-01 | 0.5249 |
64768 | IPPK | CCI_3 | Human | Cervix | CC | 5.76e-09 | 5.31e-01 | 0.516 |
64768 | IPPK | LZE4T | Human | Esophagus | ESCC | 2.12e-06 | 4.28e-02 | 0.0811 |
64768 | IPPK | LZE7T | Human | Esophagus | ESCC | 3.46e-03 | 5.74e-02 | 0.0667 |
64768 | IPPK | LZE24T | Human | Esophagus | ESCC | 5.54e-11 | 9.95e-02 | 0.0596 |
64768 | IPPK | LZE21T | Human | Esophagus | ESCC | 2.28e-02 | 2.46e-01 | 0.0655 |
64768 | IPPK | P2T-E | Human | Esophagus | ESCC | 1.96e-19 | 1.45e-01 | 0.1177 |
64768 | IPPK | P4T-E | Human | Esophagus | ESCC | 1.11e-11 | 3.70e-02 | 0.1323 |
64768 | IPPK | P5T-E | Human | Esophagus | ESCC | 3.26e-11 | 5.24e-02 | 0.1327 |
64768 | IPPK | P8T-E | Human | Esophagus | ESCC | 1.10e-04 | -3.87e-02 | 0.0889 |
64768 | IPPK | P9T-E | Human | Esophagus | ESCC | 1.50e-13 | 1.58e-01 | 0.1131 |
64768 | IPPK | P10T-E | Human | Esophagus | ESCC | 2.03e-06 | -1.43e-02 | 0.116 |
64768 | IPPK | P11T-E | Human | Esophagus | ESCC | 1.10e-02 | 3.34e-01 | 0.1426 |
64768 | IPPK | P12T-E | Human | Esophagus | ESCC | 2.23e-11 | 2.16e-01 | 0.1122 |
64768 | IPPK | P16T-E | Human | Esophagus | ESCC | 4.73e-07 | -3.59e-02 | 0.1153 |
64768 | IPPK | P20T-E | Human | Esophagus | ESCC | 1.78e-12 | 3.08e-01 | 0.1124 |
64768 | IPPK | P21T-E | Human | Esophagus | ESCC | 7.57e-13 | 3.66e-01 | 0.1617 |
64768 | IPPK | P22T-E | Human | Esophagus | ESCC | 1.89e-09 | 2.93e-02 | 0.1236 |
64768 | IPPK | P23T-E | Human | Esophagus | ESCC | 1.70e-05 | -1.61e-02 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00093032 | Esophagus | ESCC | rRNA transcription | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
GO:00063564 | Esophagus | ESCC | regulation of transcription by RNA polymerase I | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:00459432 | Esophagus | ESCC | positive regulation of transcription by RNA polymerase I | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00461653 | Esophagus | ESCC | alcohol biosynthetic process | 83/8552 | 140/18723 | 8.04e-04 | 4.16e-03 | 83 |
GO:00427902 | Esophagus | ESCC | nucleolar large rRNA transcription by RNA polymerase I | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:19018381 | Esophagus | ESCC | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:19018361 | Esophagus | ESCC | regulation of transcription of nucleolar large rRNA by RNA polymerase I | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:00987811 | Oral cavity | OSCC | ncRNA transcription | 38/7305 | 56/18723 | 1.15e-05 | 1.18e-04 | 38 |
GO:00063563 | Oral cavity | OSCC | regulation of transcription by RNA polymerase I | 25/7305 | 34/18723 | 4.63e-05 | 3.90e-04 | 25 |
GO:00063601 | Oral cavity | OSCC | transcription by RNA polymerase I | 36/7305 | 55/18723 | 6.42e-05 | 5.22e-04 | 36 |
GO:00461652 | Oral cavity | OSCC | alcohol biosynthetic process | 77/7305 | 140/18723 | 8.77e-05 | 6.70e-04 | 77 |
GO:00459431 | Oral cavity | OSCC | positive regulation of transcription by RNA polymerase I | 18/7305 | 23/18723 | 1.47e-04 | 1.04e-03 | 18 |
GO:00093031 | Oral cavity | OSCC | rRNA transcription | 24/7305 | 34/18723 | 1.89e-04 | 1.28e-03 | 24 |
GO:00427901 | Oral cavity | OSCC | nucleolar large rRNA transcription by RNA polymerase I | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IPPK | SNV | Missense_Mutation | novel | c.995T>C | p.Leu332Pro | p.L332P | Q9H8X2 | protein_coding | tolerated(0.34) | benign(0.354) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
IPPK | insertion | Frame_Shift_Ins | novel | c.205_206insG | p.Glu69GlyfsTer27 | p.E69Gfs*27 | Q9H8X2 | protein_coding | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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