GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000193327 | Thyroid | HT | negative regulation of protein phosphorylation | 45/1272 | 342/18723 | 1.54e-05 | 3.80e-04 | 45 |
GO:004232627 | Thyroid | HT | negative regulation of phosphorylation | 49/1272 | 385/18723 | 1.62e-05 | 3.95e-04 | 49 |
GO:004593629 | Thyroid | HT | negative regulation of phosphate metabolic process | 54/1272 | 441/18723 | 1.86e-05 | 4.39e-04 | 54 |
GO:001056329 | Thyroid | HT | negative regulation of phosphorus metabolic process | 54/1272 | 442/18723 | 1.99e-05 | 4.60e-04 | 54 |
GO:190290330 | Thyroid | HT | regulation of supramolecular fiber organization | 47/1272 | 383/18723 | 6.02e-05 | 1.13e-03 | 47 |
GO:003133327 | Thyroid | HT | negative regulation of protein-containing complex assembly | 23/1272 | 141/18723 | 7.64e-05 | 1.37e-03 | 23 |
GO:004325430 | Thyroid | HT | regulation of protein-containing complex assembly | 50/1272 | 428/18723 | 1.24e-04 | 2.00e-03 | 50 |
GO:001097519 | Thyroid | HT | regulation of neuron projection development | 50/1272 | 445/18723 | 3.18e-04 | 4.18e-03 | 50 |
GO:001063925 | Thyroid | HT | negative regulation of organelle organization | 39/1272 | 348/18723 | 1.45e-03 | 1.36e-02 | 39 |
GO:005125828 | Thyroid | HT | protein polymerization | 34/1272 | 297/18723 | 1.99e-03 | 1.77e-02 | 34 |
GO:190290420 | Thyroid | HT | negative regulation of supramolecular fiber organization | 22/1272 | 167/18723 | 2.14e-03 | 1.87e-02 | 22 |
GO:003111310 | Thyroid | HT | regulation of microtubule polymerization | 10/1272 | 55/18723 | 3.57e-03 | 2.73e-02 | 10 |
GO:003227128 | Thyroid | HT | regulation of protein polymerization | 27/1272 | 233/18723 | 4.64e-03 | 3.28e-02 | 27 |
GO:007050710 | Thyroid | HT | regulation of microtubule cytoskeleton organization | 19/1272 | 148/18723 | 5.50e-03 | 3.62e-02 | 19 |
GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
GO:0010563113 | Thyroid | PTC | negative regulation of phosphorus metabolic process | 219/5968 | 442/18723 | 4.47e-15 | 3.07e-13 | 219 |
GO:0045936113 | Thyroid | PTC | negative regulation of phosphate metabolic process | 218/5968 | 441/18723 | 7.08e-15 | 4.75e-13 | 218 |
GO:0001933113 | Thyroid | PTC | negative regulation of protein phosphorylation | 173/5968 | 342/18723 | 3.46e-13 | 1.75e-11 | 173 |
GO:0051258113 | Thyroid | PTC | protein polymerization | 154/5968 | 297/18723 | 5.35e-13 | 2.66e-11 | 154 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INPP5J | SNV | Missense_Mutation | rs776093227 | c.470N>T | p.Pro157Leu | p.P157L | Q15735 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | novel | c.569N>T | p.Ala190Val | p.A190V | Q15735 | protein_coding | deleterious_low_confidence(0.04) | benign(0) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
INPP5J | SNV | Missense_Mutation | rs760092310 | c.1589G>A | p.Arg530His | p.R530H | Q15735 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | novel | c.1429N>A | p.Ala477Thr | p.A477T | Q15735 | protein_coding | tolerated(0.08) | possibly_damaging(0.597) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | rs199693963 | c.2279N>A | p.Arg760His | p.R760H | Q15735 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-FI-A2EY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
INPP5J | SNV | Missense_Mutation | novel | c.2585A>G | p.Asp862Gly | p.D862G | Q15735 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.913) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | novel | c.59C>A | p.Ser20Tyr | p.S20Y | Q15735 | protein_coding | deleterious_low_confidence(0) | benign(0.259) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
INPP5J | insertion | Nonsense_Mutation | novel | c.2407_2408insGACATTATAGGGTCACAACACTGATTCCACAACACTG | p.Gln803ArgfsTer13 | p.Q803Rfs*13 | Q15735 | protein_coding | | | TCGA-B5-A0K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
INPP5J | insertion | Frame_Shift_Ins | novel | c.2739dupC | p.Ser914LeufsTer13 | p.S914Lfs*13 | Q15735 | protein_coding | | | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
INPP5J | insertion | Frame_Shift_Ins | novel | c.455_456insT | p.Val153SerfsTer40 | p.V153Sfs*40 | Q15735 | protein_coding | | | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |