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Gene: IGSF11 |
Gene summary for IGSF11 |
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Gene information | Species | Human | Gene symbol | IGSF11 | Gene ID | 152404 |
Gene name | immunoglobulin superfamily member 11 | |
Gene Alias | BT-IgSF | |
Cytomap | 3q13.32 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q5DX21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152404 | IGSF11 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.17e-02 | 6.69e-01 | -0.2602 |
152404 | IGSF11 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.26e-04 | 3.87e-01 | -0.1526 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00451851 | Colorectum | SER | maintenance of protein location | 26/2897 | 94/18723 | 1.76e-03 | 1.81e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGSF11 | SNV | Missense_Mutation | rs554488208 | c.44N>T | p.Ser15Phe | p.S15F | Q5DX21 | protein_coding | tolerated(0.28) | benign(0.007) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | c.846N>G | p.Asn282Lys | p.N282K | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-34-2600-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | novel | c.319N>T | p.Ile107Phe | p.I107F | Q5DX21 | protein_coding | tolerated(0.06) | benign(0.355) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
IGSF11 | SNV | Missense_Mutation | novel | c.329C>A | p.Thr110Asn | p.T110N | Q5DX21 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-58-A46L-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
IGSF11 | SNV | Missense_Mutation | novel | c.749N>C | p.Gly250Ala | p.G250A | Q5DX21 | protein_coding | deleterious(0.05) | benign(0.062) | TCGA-58-A46N-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
IGSF11 | SNV | Missense_Mutation | novel | c.148N>C | p.Ala50Pro | p.A50P | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-60-2715-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | PD |
IGSF11 | SNV | Missense_Mutation | c.746N>A | p.Thr249Asn | p.T249N | Q5DX21 | protein_coding | deleterious(0.01) | benign(0.357) | TCGA-66-2766-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | c.968N>A | p.Ser323Asn | p.S323N | Q5DX21 | protein_coding | tolerated(0.54) | benign(0) | TCGA-66-2770-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | novel | c.1169G>T | p.Gly390Val | p.G390V | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IGSF11 | SNV | Missense_Mutation | c.181G>T | p.Val61Phe | p.V61F | Q5DX21 | protein_coding | tolerated(0.3) | probably_damaging(0.999) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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