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Gene: IGFN1 |
Gene summary for IGFN1 |
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Gene information | Species | Human | Gene symbol | IGFN1 | Gene ID | 91156 |
Gene name | immunoglobulin like and fibronectin type III domain containing 1 | |
Gene Alias | EEF1A2BP1 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q86VF2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91156 | IGFN1 | PTC01 | Human | Thyroid | PTC | 7.13e-05 | 6.12e-02 | 0.1899 |
91156 | IGFN1 | PTC05 | Human | Thyroid | PTC | 8.79e-33 | 2.36e+00 | 0.2065 |
91156 | IGFN1 | PTC06 | Human | Thyroid | PTC | 1.43e-21 | 1.11e+00 | 0.2057 |
91156 | IGFN1 | ATC09 | Human | Thyroid | ATC | 4.63e-07 | 3.39e-01 | 0.2871 |
91156 | IGFN1 | ATC1 | Human | Thyroid | ATC | 3.84e-05 | 3.42e-01 | 0.2878 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329111 | Thyroid | PTC | cell junction assembly | 180/5968 | 420/18723 | 1.17e-06 | 1.69e-05 | 180 |
GO:00508089 | Thyroid | PTC | synapse organization | 161/5968 | 426/18723 | 5.11e-03 | 2.36e-02 | 161 |
GO:003432924 | Thyroid | ATC | cell junction assembly | 187/6293 | 420/18723 | 1.71e-06 | 2.08e-05 | 187 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGFN1 | SNV | Missense_Mutation | novel | c.8519N>A | p.Ser2840Asn | p.S2840N | Q86VF2 | protein_coding | deleterious(0.02) | benign(0.27) | TCGA-VS-A9UI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | novel | c.10688N>A | p.Pro3563His | p.P3563H | Q86VF2 | protein_coding | deleterious(0.02) | probably_damaging(0.956) | TCGA-VS-A9V2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | novel | c.2960N>G | p.His987Arg | p.H987R | Q86VF2 | protein_coding | tolerated(0.37) | benign(0.412) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | rs370712454 | c.11044G>T | p.Gly3682Trp | p.G3682W | Q86VF2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGFN1 | SNV | Missense_Mutation | novel | c.823N>A | p.Phe275Ile | p.F275I | Q86VF2 | protein_coding | deleterious(0.01) | unknown(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
IGFN1 | SNV | Missense_Mutation | c.703G>A | p.Glu235Lys | p.E235K | Q86VF2 | protein_coding | deleterious(0) | unknown(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IGFN1 | SNV | Missense_Mutation | novel | c.41N>T | p.Ser14Ile | p.S14I | Q86VF2 | protein_coding | deleterious(0.03) | unknown(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
IGFN1 | SNV | Missense_Mutation | novel | c.524N>G | p.Asp175Gly | p.D175G | Q86VF2 | protein_coding | deleterious(0) | unknown(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
IGFN1 | SNV | Missense_Mutation | rs12758581 | c.4963G>A | p.Gly1655Ser | p.G1655S | Q86VF2 | protein_coding | tolerated_low_confidence(0.08) | unknown(0) | TCGA-AA-A01X-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
IGFN1 | SNV | Missense_Mutation | c.10267G>A | p.Val3423Ile | p.V3423I | Q86VF2 | protein_coding | tolerated(0.94) | benign(0.135) | TCGA-AA-A02J-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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