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Gene: IGDCC3 |
Gene summary for IGDCC3 |
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Gene information | Species | Human | Gene symbol | IGDCC3 | Gene ID | 9543 |
Gene name | immunoglobulin superfamily DCC subclass member 3 | |
Gene Alias | HsT18880 | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8IVU1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9543 | IGDCC3 | S014 | Human | Liver | HCC | 1.71e-30 | 9.85e-01 | 0.2254 |
9543 | IGDCC3 | S015 | Human | Liver | HCC | 2.93e-30 | 1.29e+00 | 0.2375 |
9543 | IGDCC3 | S016 | Human | Liver | HCC | 7.17e-34 | 9.53e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGDCC3 | SNV | Missense_Mutation | rs563379417 | c.599G>A | p.Arg200Gln | p.R200Q | Q8IVU1 | protein_coding | tolerated(0.29) | benign(0.037) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
IGDCC3 | SNV | Missense_Mutation | novel | c.1024N>T | p.Pro342Ser | p.P342S | Q8IVU1 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGDCC3 | SNV | Missense_Mutation | rs199726544 | c.427N>A | p.Val143Met | p.V143M | Q8IVU1 | protein_coding | tolerated(0.1) | probably_damaging(0.931) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGDCC3 | SNV | Missense_Mutation | rs147682774 | c.2132N>A | p.Arg711His | p.R711H | Q8IVU1 | protein_coding | tolerated_low_confidence(0.63) | benign(0) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
IGDCC3 | SNV | Missense_Mutation | rs201555377 | c.1321N>T | p.Arg441Cys | p.R441C | Q8IVU1 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
IGDCC3 | SNV | Missense_Mutation | rs372129215 | c.2104N>T | p.Arg702Trp | p.R702W | Q8IVU1 | protein_coding | deleterious_low_confidence(0.05) | benign(0.001) | TCGA-BD-A3EP-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGDCC3 | SNV | Missense_Mutation | novel | c.1211N>G | p.Asn404Ser | p.N404S | Q8IVU1 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CC-A8HT-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
IGDCC3 | SNV | Missense_Mutation | novel | c.1142A>G | p.Asn381Ser | p.N381S | Q8IVU1 | protein_coding | tolerated(0.09) | benign(0.359) | TCGA-CC-A9FS-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
IGDCC3 | SNV | Missense_Mutation | c.1823N>A | p.Arg608His | p.R608H | Q8IVU1 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-DD-A73F-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IGDCC3 | SNV | Missense_Mutation | rs148656626 | c.1303G>A | p.Val435Met | p.V435M | Q8IVU1 | protein_coding | tolerated(0.18) | possibly_damaging(0.839) | TCGA-FV-A4ZQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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