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Gene: HSPA4 |
Gene summary for HSPA4 |
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Gene information | Species | Human | Gene symbol | HSPA4 | Gene ID | 3308 |
Gene name | heat shock protein family A (Hsp70) member 4 | |
Gene Alias | APG-2 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | P34932 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3308 | HSPA4 | LZE2T | Human | Esophagus | ESCC | 3.36e-03 | 1.20e+00 | 0.082 |
3308 | HSPA4 | LZE4T | Human | Esophagus | ESCC | 9.06e-14 | 6.69e-01 | 0.0811 |
3308 | HSPA4 | LZE5T | Human | Esophagus | ESCC | 4.25e-03 | -2.22e-03 | 0.0514 |
3308 | HSPA4 | LZE7T | Human | Esophagus | ESCC | 7.23e-03 | 4.92e-01 | 0.0667 |
3308 | HSPA4 | LZE20T | Human | Esophagus | ESCC | 1.79e-03 | 1.08e-01 | 0.0662 |
3308 | HSPA4 | LZE22T | Human | Esophagus | ESCC | 1.09e-02 | 7.19e-01 | 0.068 |
3308 | HSPA4 | LZE24T | Human | Esophagus | ESCC | 4.96e-12 | 5.83e-01 | 0.0596 |
3308 | HSPA4 | LZE6T | Human | Esophagus | ESCC | 1.06e-08 | 5.01e-01 | 0.0845 |
3308 | HSPA4 | P1T-E | Human | Esophagus | ESCC | 6.01e-04 | 2.63e-01 | 0.0875 |
3308 | HSPA4 | P2T-E | Human | Esophagus | ESCC | 1.57e-40 | 8.47e-01 | 0.1177 |
3308 | HSPA4 | P4T-E | Human | Esophagus | ESCC | 7.80e-24 | 8.86e-01 | 0.1323 |
3308 | HSPA4 | P5T-E | Human | Esophagus | ESCC | 3.05e-35 | 8.90e-01 | 0.1327 |
3308 | HSPA4 | P8T-E | Human | Esophagus | ESCC | 2.94e-17 | 3.24e-02 | 0.0889 |
3308 | HSPA4 | P9T-E | Human | Esophagus | ESCC | 2.63e-13 | 3.10e-01 | 0.1131 |
3308 | HSPA4 | P10T-E | Human | Esophagus | ESCC | 5.06e-12 | 2.95e-01 | 0.116 |
3308 | HSPA4 | P11T-E | Human | Esophagus | ESCC | 1.48e-14 | 6.52e-01 | 0.1426 |
3308 | HSPA4 | P12T-E | Human | Esophagus | ESCC | 8.83e-48 | 1.01e+00 | 0.1122 |
3308 | HSPA4 | P15T-E | Human | Esophagus | ESCC | 5.08e-26 | 9.43e-01 | 0.1149 |
3308 | HSPA4 | P16T-E | Human | Esophagus | ESCC | 3.24e-22 | 6.51e-01 | 0.1153 |
3308 | HSPA4 | P17T-E | Human | Esophagus | ESCC | 1.33e-10 | 6.99e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0035966111 | Esophagus | ESCC | response to topologically incorrect protein | 125/8552 | 159/18723 | 1.44e-17 | 1.27e-15 | 125 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:0072655110 | Esophagus | ESCC | establishment of protein localization to mitochondrion | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:0070585110 | Esophagus | ESCC | protein localization to mitochondrion | 100/8552 | 125/18723 | 2.96e-15 | 1.77e-13 | 100 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:0006986111 | Esophagus | ESCC | response to unfolded protein | 107/8552 | 137/18723 | 7.01e-15 | 3.87e-13 | 107 |
GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
GO:0006626110 | Esophagus | ESCC | protein targeting to mitochondrion | 81/8552 | 100/18723 | 3.60e-13 | 1.67e-11 | 81 |
GO:005120515 | Esophagus | ESCC | protein insertion into membrane | 46/8552 | 57/18723 | 5.90e-08 | 1.04e-06 | 46 |
GO:009015118 | Esophagus | ESCC | establishment of protein localization to mitochondrial membrane | 26/8552 | 30/18723 | 3.79e-06 | 4.12e-05 | 26 |
GO:005120416 | Esophagus | ESCC | protein insertion into mitochondrial membrane | 21/8552 | 25/18723 | 9.12e-05 | 6.54e-04 | 21 |
GO:005113119 | Esophagus | ESCC | chaperone-mediated protein complex assembly | 17/8552 | 23/18723 | 5.73e-03 | 2.13e-02 | 17 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:007259412 | Liver | Cirrhotic | establishment of protein localization to organelle | 189/4634 | 422/18723 | 1.01e-19 | 2.45e-17 | 189 |
GO:00359667 | Liver | Cirrhotic | response to topologically incorrect protein | 91/4634 | 159/18723 | 2.07e-18 | 3.60e-16 | 91 |
GO:00066057 | Liver | Cirrhotic | protein targeting | 148/4634 | 314/18723 | 3.86e-18 | 6.20e-16 | 148 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05417211 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa04530211 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0461230 | Esophagus | ESCC | Antigen processing and presentation | 51/4205 | 78/8465 | 3.57e-03 | 9.34e-03 | 4.78e-03 | 51 |
hsa05417310 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa04530310 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa04612114 | Esophagus | ESCC | Antigen processing and presentation | 51/4205 | 78/8465 | 3.57e-03 | 9.34e-03 | 4.78e-03 | 51 |
hsa0453022 | Liver | Cirrhotic | Tight junction | 82/2530 | 169/8465 | 2.14e-07 | 2.85e-06 | 1.76e-06 | 82 |
hsa0461214 | Liver | Cirrhotic | Antigen processing and presentation | 36/2530 | 78/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 36 |
hsa0541722 | Liver | Cirrhotic | Lipid and atherosclerosis | 80/2530 | 215/8465 | 1.18e-02 | 3.81e-02 | 2.35e-02 | 80 |
hsa0453032 | Liver | Cirrhotic | Tight junction | 82/2530 | 169/8465 | 2.14e-07 | 2.85e-06 | 1.76e-06 | 82 |
hsa0461215 | Liver | Cirrhotic | Antigen processing and presentation | 36/2530 | 78/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 36 |
hsa0541732 | Liver | Cirrhotic | Lipid and atherosclerosis | 80/2530 | 215/8465 | 1.18e-02 | 3.81e-02 | 2.35e-02 | 80 |
hsa0453042 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa0541742 | Liver | HCC | Lipid and atherosclerosis | 118/4020 | 215/8465 | 1.66e-02 | 3.92e-02 | 2.18e-02 | 118 |
hsa0453052 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa0541752 | Liver | HCC | Lipid and atherosclerosis | 118/4020 | 215/8465 | 1.66e-02 | 3.92e-02 | 2.18e-02 | 118 |
hsa0541730 | Oral cavity | OSCC | Lipid and atherosclerosis | 131/3704 | 215/8465 | 2.20e-07 | 1.45e-06 | 7.37e-07 | 131 |
hsa0453030 | Oral cavity | OSCC | Tight junction | 102/3704 | 169/8465 | 8.68e-06 | 3.93e-05 | 2.00e-05 | 102 |
hsa0461229 | Oral cavity | OSCC | Antigen processing and presentation | 47/3704 | 78/8465 | 2.37e-03 | 6.35e-03 | 3.23e-03 | 47 |
hsa05417113 | Oral cavity | OSCC | Lipid and atherosclerosis | 131/3704 | 215/8465 | 2.20e-07 | 1.45e-06 | 7.37e-07 | 131 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPA4 | SNV | Missense_Mutation | rs377082440 | c.2483N>T | p.Ser828Leu | p.S828L | P34932 | protein_coding | tolerated(0.1) | benign(0) | TCGA-FI-A2EX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HSPA4 | SNV | Missense_Mutation | novel | c.183G>T | p.Lys61Asn | p.K61N | P34932 | protein_coding | tolerated(0.18) | possibly_damaging(0.583) | TCGA-QS-A5YQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
HSPA4 | deletion | Frame_Shift_Del | c.2390delN | p.Asn799MetfsTer50 | p.N799Mfs*50 | P34932 | protein_coding | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
HSPA4 | SNV | Missense_Mutation | c.128C>T | p.Pro43Leu | p.P43L | P34932 | protein_coding | tolerated(0.22) | benign(0.038) | TCGA-CC-A3M9-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
HSPA4 | SNV | Missense_Mutation | novel | c.1048N>T | p.Val350Leu | p.V350L | P34932 | protein_coding | deleterious(0.04) | benign(0.109) | TCGA-86-7954-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
HSPA4 | SNV | Missense_Mutation | c.632N>T | p.Ser211Phe | p.S211F | P34932 | protein_coding | tolerated(0.06) | possibly_damaging(0.899) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HSPA4 | SNV | Missense_Mutation | c.243G>T | p.Glu81Asp | p.E81D | P34932 | protein_coding | deleterious(0.02) | benign(0.038) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
HSPA4 | SNV | Missense_Mutation | c.551N>G | p.Tyr184Cys | p.Y184C | P34932 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-37-4135-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HSPA4 | SNV | Missense_Mutation | novel | c.1900N>T | p.Gly634Cys | p.G634C | P34932 | protein_coding | deleterious(0) | possibly_damaging(0.769) | TCGA-43-3920-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HSPA4 | SNV | Missense_Mutation | c.1201N>T | p.Pro401Ser | p.P401S | P34932 | protein_coding | tolerated(0.38) | benign(0.02) | TCGA-46-3768-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3308 | HSPA4 | NA | UREA | UREA | 7548155 | |
3308 | HSPA4 | NA | PHOSPHODIESTERASE INHIBITOR | 9383212 | ||
3308 | HSPA4 | NA | AEG-33773 | |||
3308 | HSPA4 | NA | TRAIL | 12460647 | ||
3308 | HSPA4 | NA | GOSSYPOL | GOSSYPOL | 2193225 | |
3308 | HSPA4 | NA | NIMESULIDE | NIMESULIDE | 9645681 | |
3308 | HSPA4 | NA | KETANSERIN | KETANSERIN | 9864262 | |
3308 | HSPA4 | NA | CYTARABINE | CYTARABINE | 12530536 | |
3308 | HSPA4 | NA | POH | 17024970 | ||
3308 | HSPA4 | NA | CISPLATIN | CISPLATIN | 11478701 |
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