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Gene: HKR1 |
Gene summary for HKR1 |
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Gene information | Species | Human | Gene symbol | HKR1 | Gene ID | 284459 |
Gene name | zinc finger protein 875 | |
Gene Alias | HKR1 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | K7EPW3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284459 | HKR1 | AEH-subject1 | Human | Endometrium | AEH | 7.85e-04 | -1.32e-01 | -0.3059 |
284459 | HKR1 | AEH-subject2 | Human | Endometrium | AEH | 6.38e-09 | -1.32e-01 | -0.2525 |
284459 | HKR1 | AEH-subject3 | Human | Endometrium | AEH | 3.51e-03 | -1.32e-01 | -0.2576 |
284459 | HKR1 | AEH-subject4 | Human | Endometrium | AEH | 2.33e-06 | -1.32e-01 | -0.2657 |
284459 | HKR1 | AEH-subject5 | Human | Endometrium | AEH | 3.51e-03 | -1.32e-01 | -0.2953 |
284459 | HKR1 | EEC-subject1 | Human | Endometrium | EEC | 1.75e-04 | -1.32e-01 | -0.2682 |
284459 | HKR1 | EEC-subject2 | Human | Endometrium | EEC | 1.66e-03 | -1.32e-01 | -0.2607 |
284459 | HKR1 | EEC-subject3 | Human | Endometrium | EEC | 8.23e-05 | -1.32e-01 | -0.2525 |
284459 | HKR1 | EEC-subject4 | Human | Endometrium | EEC | 3.71e-04 | -1.32e-01 | -0.2571 |
284459 | HKR1 | EEC-subject5 | Human | Endometrium | EEC | 7.40e-03 | -1.32e-01 | -0.249 |
284459 | HKR1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.97e-05 | -4.29e-02 | -0.1869 |
284459 | HKR1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.47e-08 | -2.66e-02 | -0.1875 |
284459 | HKR1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.64e-06 | -1.18e-01 | -0.1883 |
284459 | HKR1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.21e-03 | -8.01e-02 | -0.1917 |
284459 | HKR1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.35e-10 | -3.99e-02 | -0.1916 |
284459 | HKR1 | PTC01 | Human | Thyroid | PTC | 5.73e-04 | 8.78e-02 | 0.1899 |
284459 | HKR1 | PTC03 | Human | Thyroid | PTC | 3.21e-04 | 1.34e-01 | 0.1784 |
284459 | HKR1 | PTC04 | Human | Thyroid | PTC | 3.20e-11 | 1.77e-01 | 0.1927 |
284459 | HKR1 | PTC05 | Human | Thyroid | PTC | 1.21e-06 | 3.26e-01 | 0.2065 |
284459 | HKR1 | PTC06 | Human | Thyroid | PTC | 4.63e-15 | 2.90e-01 | 0.2057 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HKR1 | CD8TEFF | Breast | DCIS | CCR4,AC013264.1,LIMK1, etc. | 1.12e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HKR1 | SNV | Missense_Mutation | novel | c.423N>G | p.Ser141Arg | p.S141R | P10072 | protein_coding | tolerated(0.21) | probably_damaging(0.915) | TCGA-73-4675-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | alimta | PD |
HKR1 | SNV | Missense_Mutation | novel | c.1592G>T | p.Gly531Val | p.G531V | P10072 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HKR1 | SNV | Missense_Mutation | c.1671N>T | p.Glu557Asp | p.E557D | P10072 | protein_coding | tolerated(0.08) | benign(0.142) | TCGA-91-6828-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HKR1 | SNV | Missense_Mutation | novel | c.506G>T | p.Gly169Val | p.G169V | P10072 | protein_coding | tolerated(0.07) | benign(0.021) | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HKR1 | SNV | Missense_Mutation | c.1751N>T | p.Cys584Phe | p.C584F | P10072 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-97-7937-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HKR1 | SNV | Missense_Mutation | c.1423N>T | p.Gly475Trp | p.G475W | P10072 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-97-7938-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HKR1 | SNV | Missense_Mutation | c.1424N>T | p.Gly475Val | p.G475V | P10072 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-97-7938-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HKR1 | SNV | Missense_Mutation | novel | c.1906N>G | p.Ile636Val | p.I636V | P10072 | protein_coding | tolerated(1) | benign(0.003) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HKR1 | SNV | Missense_Mutation | novel | c.1043N>T | p.Gln348Leu | p.Q348L | P10072 | protein_coding | tolerated(0.1) | possibly_damaging(0.575) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
HKR1 | SNV | Missense_Mutation | novel | c.1023N>T | p.Lys341Asn | p.K341N | P10072 | protein_coding | deleterious(0.01) | benign(0.061) | TCGA-34-A5IX-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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