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Gene: HID1 |
Gene summary for HID1 |
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Gene information | Species | Human | Gene symbol | HID1 | Gene ID | 283987 |
Gene name | HID1 domain containing | |
Gene Alias | 17orf28 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000138 | UniProtAcc | Q8IV36 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
283987 | HID1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.30e-04 | 2.55e-01 | -0.0811 |
283987 | HID1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.23e-03 | 2.14e-01 | -0.1088 |
283987 | HID1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.00e-02 | 6.64e-01 | -0.2196 |
283987 | HID1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.47e-10 | 3.15e-01 | -0.1464 |
283987 | HID1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.59e-09 | 2.77e-01 | -0.1001 |
283987 | HID1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.56e-03 | 2.37e-01 | -0.059 |
283987 | HID1 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.02e-03 | 3.73e-01 | -0.0842 |
283987 | HID1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.84e-02 | 1.13e-01 | 0.0674 |
283987 | HID1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.95e-05 | 6.36e-01 | 0.3487 |
283987 | HID1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.42e-03 | 2.87e-01 | 0.281 |
283987 | HID1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.75e-05 | 2.51e-01 | 0.3859 |
283987 | HID1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.13e-06 | 2.06e-01 | 0.3005 |
283987 | HID1 | LZE22T | Human | Esophagus | ESCC | 5.47e-03 | 1.94e-01 | 0.068 |
283987 | HID1 | P8T-E | Human | Esophagus | ESCC | 2.62e-13 | 2.69e-01 | 0.0889 |
283987 | HID1 | P10T-E | Human | Esophagus | ESCC | 8.02e-06 | 5.72e-02 | 0.116 |
283987 | HID1 | P12T-E | Human | Esophagus | ESCC | 2.10e-06 | 7.01e-02 | 0.1122 |
283987 | HID1 | P15T-E | Human | Esophagus | ESCC | 2.34e-06 | 5.32e-02 | 0.1149 |
283987 | HID1 | P16T-E | Human | Esophagus | ESCC | 2.19e-05 | 8.43e-02 | 0.1153 |
283987 | HID1 | P27T-E | Human | Esophagus | ESCC | 3.41e-02 | 1.28e-02 | 0.1055 |
283987 | HID1 | P28T-E | Human | Esophagus | ESCC | 5.28e-04 | 1.36e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HID1 | SNV | Missense_Mutation | c.1120N>A | p.Leu374Ile | p.L374I | Q8IV36 | protein_coding | tolerated(0.1) | benign(0.163) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HID1 | SNV | Missense_Mutation | rs750214001 | c.1040N>A | p.Arg347Gln | p.R347Q | Q8IV36 | protein_coding | deleterious(0.03) | benign(0.154) | TCGA-EY-A1H0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
HID1 | SNV | Missense_Mutation | rs766623481 | c.829N>T | p.Arg277Trp | p.R277W | Q8IV36 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HID1 | SNV | Missense_Mutation | c.2210N>T | p.Pro737Leu | p.P737L | Q8IV36 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HID1 | insertion | Frame_Shift_Ins | novel | c.583dupC | p.Gln195ProfsTer3 | p.Q195Pfs*3 | Q8IV36 | protein_coding | TCGA-B5-A11J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HID1 | SNV | Missense_Mutation | c.346G>T | p.Gly116Cys | p.G116C | Q8IV36 | protein_coding | deleterious(0) | benign(0.288) | TCGA-CC-A7IG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
HID1 | SNV | Missense_Mutation | novel | c.511N>A | p.Ala171Thr | p.A171T | Q8IV36 | protein_coding | tolerated(0.14) | benign(0.033) | TCGA-DD-AADN-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HID1 | SNV | Missense_Mutation | c.1294G>A | p.Glu432Lys | p.E432K | Q8IV36 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-50-5933-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
HID1 | SNV | Missense_Mutation | novel | c.1040G>T | p.Arg347Leu | p.R347L | Q8IV36 | protein_coding | deleterious(0.01) | benign(0.107) | TCGA-97-7546-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD |
HID1 | SNV | Missense_Mutation | novel | c.1802G>C | p.Gly601Ala | p.G601A | Q8IV36 | protein_coding | tolerated(0.4) | benign(0.081) | TCGA-MP-A4T4-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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