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Gene: HECTD3 |
Gene summary for HECTD3 |
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Gene information | Species | Human | Gene symbol | HECTD3 | Gene ID | 79654 |
Gene name | HECT domain E3 ubiquitin protein ligase 3 | |
Gene Alias | HECTD3 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A1A4G1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79654 | HECTD3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.10e-12 | 4.60e-01 | -0.1808 |
79654 | HECTD3 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.90e-02 | 1.75e-01 | -0.1088 |
79654 | HECTD3 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.93e-13 | 3.79e-01 | -0.1954 |
79654 | HECTD3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.42e-05 | 7.41e-01 | -0.2602 |
79654 | HECTD3 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.24e-06 | 2.63e-01 | -0.1526 |
79654 | HECTD3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.05e-05 | 3.02e-01 | -0.1464 |
79654 | HECTD3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.52e-02 | 2.44e-01 | -0.059 |
79654 | HECTD3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.82e-03 | 4.19e-01 | -0.2061 |
79654 | HECTD3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.61e-03 | 4.79e-01 | -0.1462 |
79654 | HECTD3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.78e-02 | 2.43e-01 | 0.0674 |
79654 | HECTD3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.68e-03 | 1.91e-01 | 0.3859 |
79654 | HECTD3 | LZE20T | Human | Esophagus | ESCC | 1.64e-05 | 1.12e-01 | 0.0662 |
79654 | HECTD3 | LZE24T | Human | Esophagus | ESCC | 2.16e-07 | 1.88e-01 | 0.0596 |
79654 | HECTD3 | P2T-E | Human | Esophagus | ESCC | 2.08e-09 | 1.18e-01 | 0.1177 |
79654 | HECTD3 | P4T-E | Human | Esophagus | ESCC | 4.30e-05 | 7.80e-02 | 0.1323 |
79654 | HECTD3 | P5T-E | Human | Esophagus | ESCC | 1.87e-04 | 2.91e-02 | 0.1327 |
79654 | HECTD3 | P8T-E | Human | Esophagus | ESCC | 6.64e-08 | 1.53e-01 | 0.0889 |
79654 | HECTD3 | P10T-E | Human | Esophagus | ESCC | 3.72e-06 | 1.11e-01 | 0.116 |
79654 | HECTD3 | P11T-E | Human | Esophagus | ESCC | 2.14e-07 | 2.50e-01 | 0.1426 |
79654 | HECTD3 | P12T-E | Human | Esophagus | ESCC | 4.78e-15 | 1.30e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HECTD3 | SNV | Missense_Mutation | c.2153N>A | p.Met718Lys | p.M718K | Q5T447 | protein_coding | deleterious(0) | benign(0.396) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
HECTD3 | SNV | Missense_Mutation | novel | c.1908G>T | p.Lys636Asn | p.K636N | Q5T447 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-73-4675-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | alimta | PD |
HECTD3 | SNV | Missense_Mutation | rs780936179 | c.1690N>A | p.Val564Met | p.V564M | Q5T447 | protein_coding | tolerated(0.23) | benign(0.115) | TCGA-97-A4M3-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HECTD3 | SNV | Missense_Mutation | novel | c.904N>A | p.Asp302Asn | p.D302N | Q5T447 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-NJ-A4YG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HECTD3 | SNV | Missense_Mutation | novel | c.2053N>T | p.Gly685Trp | p.G685W | Q5T447 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-18-3419-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HECTD3 | SNV | Missense_Mutation | c.2468N>A | p.Cys823Tyr | p.C823Y | Q5T447 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
HECTD3 | SNV | Missense_Mutation | c.2443N>A | p.Asp815Asn | p.D815N | Q5T447 | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-66-2754-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
HECTD3 | SNV | Missense_Mutation | novel | c.131C>G | p.Pro44Arg | p.P44R | Q5T447 | protein_coding | deleterious(0) | possibly_damaging(0.737) | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
HECTD3 | deletion | Frame_Shift_Del | c.1129delN | p.Glu377AsnfsTer2 | p.E377Nfs*2 | Q5T447 | protein_coding | TCGA-69-7765-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD | |||
HECTD3 | SNV | Missense_Mutation | c.637N>G | p.Thr213Ala | p.T213A | Q5T447 | protein_coding | tolerated(0.17) | benign(0.027) | TCGA-BB-4225-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unspecific | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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