![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: H2AFY2 |
Gene summary for H2AFY2 |
![]() |
Gene information | Species | Human | Gene symbol | H2AFY2 | Gene ID | 55506 |
Gene name | macroH2A.2 histone | |
Gene Alias | H2AFY2 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024QZP6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55506 | H2AFY2 | LZE2T | Human | Esophagus | ESCC | 4.16e-02 | 4.25e-01 | 0.082 |
55506 | H2AFY2 | LZE4T | Human | Esophagus | ESCC | 7.90e-03 | 1.72e-01 | 0.0811 |
55506 | H2AFY2 | LZE7T | Human | Esophagus | ESCC | 6.14e-12 | 5.23e-01 | 0.0667 |
55506 | H2AFY2 | LZE8T | Human | Esophagus | ESCC | 1.80e-08 | 2.45e-01 | 0.067 |
55506 | H2AFY2 | LZE22T | Human | Esophagus | ESCC | 4.26e-04 | 5.44e-01 | 0.068 |
55506 | H2AFY2 | LZE24T | Human | Esophagus | ESCC | 7.46e-29 | 7.29e-01 | 0.0596 |
55506 | H2AFY2 | LZE21T | Human | Esophagus | ESCC | 7.03e-07 | 3.88e-01 | 0.0655 |
55506 | H2AFY2 | P1T-E | Human | Esophagus | ESCC | 7.10e-13 | 3.41e-01 | 0.0875 |
55506 | H2AFY2 | P2T-E | Human | Esophagus | ESCC | 5.42e-79 | 1.34e+00 | 0.1177 |
55506 | H2AFY2 | P4T-E | Human | Esophagus | ESCC | 1.10e-45 | 9.10e-01 | 0.1323 |
55506 | H2AFY2 | P5T-E | Human | Esophagus | ESCC | 1.45e-15 | 3.21e-01 | 0.1327 |
55506 | H2AFY2 | P8T-E | Human | Esophagus | ESCC | 2.82e-28 | 4.84e-01 | 0.0889 |
55506 | H2AFY2 | P9T-E | Human | Esophagus | ESCC | 6.73e-06 | 1.28e-01 | 0.1131 |
55506 | H2AFY2 | P10T-E | Human | Esophagus | ESCC | 1.89e-42 | 6.67e-01 | 0.116 |
55506 | H2AFY2 | P11T-E | Human | Esophagus | ESCC | 1.84e-10 | 4.74e-01 | 0.1426 |
55506 | H2AFY2 | P12T-E | Human | Esophagus | ESCC | 8.28e-50 | 8.93e-01 | 0.1122 |
55506 | H2AFY2 | P15T-E | Human | Esophagus | ESCC | 1.07e-38 | 8.46e-01 | 0.1149 |
55506 | H2AFY2 | P16T-E | Human | Esophagus | ESCC | 5.29e-48 | 8.51e-01 | 0.1153 |
55506 | H2AFY2 | P17T-E | Human | Esophagus | ESCC | 1.02e-05 | 3.74e-01 | 0.1278 |
55506 | H2AFY2 | P20T-E | Human | Esophagus | ESCC | 5.69e-27 | 6.39e-01 | 0.1124 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
H2AFY2 | deletion | Frame_Shift_Del | c.438delG | p.Lys147ArgfsTer53 | p.K147Rfs*53 | Q9P0M6 | protein_coding | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |