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Gene: GTDC1 |
Gene summary for GTDC1 |
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Gene information | Species | Human | Gene symbol | GTDC1 | Gene ID | 79712 |
Gene name | glycosyltransferase like domain containing 1 | |
Gene Alias | Hmat-Xa | |
Cytomap | 2q22.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q4AE62 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79712 | GTDC1 | CCI_1 | Human | Cervix | CC | 9.22e-14 | 9.30e-01 | 0.528 |
79712 | GTDC1 | CCI_3 | Human | Cervix | CC | 1.02e-10 | 6.51e-01 | 0.516 |
79712 | GTDC1 | LZE4T | Human | Esophagus | ESCC | 2.90e-08 | 2.22e-01 | 0.0811 |
79712 | GTDC1 | LZE7T | Human | Esophagus | ESCC | 2.99e-05 | 2.35e-01 | 0.0667 |
79712 | GTDC1 | LZE24T | Human | Esophagus | ESCC | 1.88e-02 | 5.05e-02 | 0.0596 |
79712 | GTDC1 | P2T-E | Human | Esophagus | ESCC | 1.09e-02 | 1.68e-02 | 0.1177 |
79712 | GTDC1 | P4T-E | Human | Esophagus | ESCC | 3.95e-06 | 1.80e-01 | 0.1323 |
79712 | GTDC1 | P5T-E | Human | Esophagus | ESCC | 1.14e-18 | 2.51e-01 | 0.1327 |
79712 | GTDC1 | P8T-E | Human | Esophagus | ESCC | 7.85e-12 | 9.34e-02 | 0.0889 |
79712 | GTDC1 | P9T-E | Human | Esophagus | ESCC | 5.18e-04 | 6.63e-02 | 0.1131 |
79712 | GTDC1 | P10T-E | Human | Esophagus | ESCC | 6.56e-09 | 1.50e-01 | 0.116 |
79712 | GTDC1 | P11T-E | Human | Esophagus | ESCC | 1.17e-09 | 2.87e-01 | 0.1426 |
79712 | GTDC1 | P12T-E | Human | Esophagus | ESCC | 8.61e-13 | 2.98e-01 | 0.1122 |
79712 | GTDC1 | P15T-E | Human | Esophagus | ESCC | 1.84e-12 | 2.82e-01 | 0.1149 |
79712 | GTDC1 | P16T-E | Human | Esophagus | ESCC | 5.23e-07 | 2.87e-02 | 0.1153 |
79712 | GTDC1 | P20T-E | Human | Esophagus | ESCC | 3.99e-02 | 5.94e-02 | 0.1124 |
79712 | GTDC1 | P21T-E | Human | Esophagus | ESCC | 6.71e-09 | 8.02e-02 | 0.1617 |
79712 | GTDC1 | P22T-E | Human | Esophagus | ESCC | 4.25e-04 | 1.13e-01 | 0.1236 |
79712 | GTDC1 | P23T-E | Human | Esophagus | ESCC | 3.58e-07 | 2.14e-01 | 0.108 |
79712 | GTDC1 | P24T-E | Human | Esophagus | ESCC | 1.26e-03 | 9.43e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTDC1 | SNV | Missense_Mutation | novel | c.1080N>T | p.Met360Ile | p.M360I | Q4AE62 | protein_coding | tolerated(0.18) | benign(0.139) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
GTDC1 | SNV | Missense_Mutation | c.1057N>T | p.Asp353Tyr | p.D353Y | Q4AE62 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTDC1 | SNV | Missense_Mutation | c.385A>T | p.Asn129Tyr | p.N129Y | Q4AE62 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-5643-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD | |
GTDC1 | SNV | Missense_Mutation | rs114787738 | c.71N>T | p.Glu24Val | p.E24V | Q4AE62 | protein_coding | deleterious(0.03) | possibly_damaging(0.455) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTDC1 | SNV | Missense_Mutation | c.778N>T | p.Gly260Cys | p.G260C | Q4AE62 | protein_coding | tolerated_low_confidence(0.05) | benign(0.319) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD | |
GTDC1 | SNV | Missense_Mutation | c.1049N>A | p.Ser350Asn | p.S350N | Q4AE62 | protein_coding | tolerated(0.09) | possibly_damaging(0.812) | TCGA-55-7570-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GTDC1 | SNV | Missense_Mutation | c.5G>T | p.Ser2Ile | p.S2I | Q4AE62 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
GTDC1 | SNV | Missense_Mutation | c.22N>T | p.Ala8Ser | p.A8S | Q4AE62 | protein_coding | tolerated(0.15) | possibly_damaging(0.862) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
GTDC1 | SNV | Missense_Mutation | c.1241G>T | p.Arg414Met | p.R414M | Q4AE62 | protein_coding | tolerated(0.13) | probably_damaging(0.947) | TCGA-97-A4M7-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GTDC1 | SNV | Missense_Mutation | c.255N>C | p.Lys85Asn | p.K85N | Q4AE62 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MP-A4SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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