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Gene: GRM8 |
Gene summary for GRM8 |
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Gene information | Species | Human | Gene symbol | GRM8 | Gene ID | 2918 |
Gene name | glutamate metabotropic receptor 8 | |
Gene Alias | GLUR8 | |
Cytomap | 7q31.33 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O00222 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2918 | GRM8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.15e-03 | 6.54e-01 | -0.0811 |
2918 | GRM8 | HTA11_78_2000001011 | Human | Colorectum | AD | 9.09e-05 | 8.37e-01 | -0.1088 |
2918 | GRM8 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.85e-02 | 4.24e-01 | -0.1001 |
2918 | GRM8 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.87e-05 | 4.38e-01 | 0.0674 |
2918 | GRM8 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.59e-09 | 1.13e+00 | 0.0112 |
2918 | GRM8 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.25e-25 | 1.50e+00 | 0.0588 |
2918 | GRM8 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.65e-18 | 1.60e+00 | 0.281 |
2918 | GRM8 | A002-C-010 | Human | Colorectum | FAP | 2.99e-08 | 5.97e-01 | 0.242 |
2918 | GRM8 | A001-C-207 | Human | Colorectum | FAP | 1.32e-11 | 7.95e-01 | 0.1278 |
2918 | GRM8 | A015-C-204 | Human | Colorectum | FAP | 6.52e-04 | 5.19e-01 | -0.0228 |
2918 | GRM8 | A002-C-203 | Human | Colorectum | FAP | 2.36e-07 | 4.76e-01 | 0.2786 |
2918 | GRM8 | A001-C-108 | Human | Colorectum | FAP | 6.60e-07 | 5.24e-01 | -0.0272 |
2918 | GRM8 | A001-C-104 | Human | Colorectum | FAP | 8.00e-23 | 8.57e-01 | 0.0184 |
2918 | GRM8 | A015-C-106 | Human | Colorectum | FAP | 3.63e-13 | 6.75e-01 | -0.0511 |
2918 | GRM8 | A015-C-104 | Human | Colorectum | FAP | 1.14e-02 | -5.67e-02 | -0.1899 |
2918 | GRM8 | A015-C-202 | Human | Colorectum | FAP | 1.17e-11 | 6.09e-01 | -0.0849 |
2918 | GRM8 | A001-C-014 | Human | Colorectum | FAP | 8.86e-14 | 7.05e-01 | 0.0135 |
2918 | GRM8 | A002-C-016 | Human | Colorectum | FAP | 7.23e-03 | 2.56e-01 | 0.0521 |
2918 | GRM8 | A015-C-002 | Human | Colorectum | FAP | 6.03e-13 | 8.13e-01 | -0.0763 |
2918 | GRM8 | A001-C-203 | Human | Colorectum | FAP | 1.08e-04 | 4.89e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04724 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
hsa047241 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRM8 | SNV | Missense_Mutation | c.1924N>A | p.Ala642Thr | p.A642T | O00222 | protein_coding | tolerated(0.25) | benign(0.005) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | rs750295333 | c.302N>A | p.Arg101His | p.R101H | O00222 | protein_coding | tolerated(0.87) | benign(0.07) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRM8 | SNV | Missense_Mutation | c.56C>T | p.Ala19Val | p.A19V | O00222 | protein_coding | tolerated_low_confidence(0.5) | benign(0.015) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | c.646A>G | p.Asn216Asp | p.N216D | O00222 | protein_coding | deleterious(0.01) | benign(0.196) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | rs376254689 | c.433G>A | p.Asp145Asn | p.D145N | O00222 | protein_coding | tolerated(0.27) | benign(0.363) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRM8 | SNV | Missense_Mutation | c.1316N>T | p.Gly439Val | p.G439V | O00222 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | c.2356N>G | p.Thr786Ala | p.T786A | O00222 | protein_coding | deleterious(0.04) | benign(0.326) | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | c.2498N>G | p.Leu833Arg | p.L833R | O00222 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
GRM8 | SNV | Missense_Mutation | rs760758747 | c.89N>T | p.Arg30Ile | p.R30I | O00222 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
GRM8 | SNV | Missense_Mutation | novel | c.1750N>C | p.Ala584Pro | p.A584P | O00222 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650554 | EGLUMEGAD | |
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135650552 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 178102837 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651136 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 381744920 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650507 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651511 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650159 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651501 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650510 |
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