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Gene: GRK2 |
Gene summary for GRK2 |
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Gene information | Species | Human | Gene symbol | GRK2 | Gene ID | 156 |
Gene name | G protein-coupled receptor kinase 2 | |
Gene Alias | ADRBK1 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0002026 | UniProtAcc | A0A0S2Z392 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
156 | GRK2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.33e-05 | 1.91e-01 | 0.0155 |
156 | GRK2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.49e-05 | 3.73e-01 | -0.1808 |
156 | GRK2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.80e-03 | 3.17e-01 | -0.0811 |
156 | GRK2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.50e-02 | 1.05e-01 | -0.1954 |
156 | GRK2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.54e-02 | 2.37e-01 | -0.1207 |
156 | GRK2 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.24e-03 | 2.49e-01 | -0.1526 |
156 | GRK2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.94e-11 | 2.98e-01 | -0.1464 |
156 | GRK2 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.57e-03 | 1.56e-01 | -0.1001 |
156 | GRK2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.10e-04 | 2.60e-01 | -0.059 |
156 | GRK2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.13e-04 | 2.87e-01 | 0.0338 |
156 | GRK2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.42e-10 | 3.28e-01 | 0.0674 |
156 | GRK2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.99e-04 | 2.58e-01 | 0.0588 |
156 | GRK2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.96e-20 | 5.99e-01 | 0.3859 |
156 | GRK2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.74e-08 | 2.35e-01 | 0.3005 |
156 | GRK2 | HCC1 | Human | Liver | HCC | 5.40e-03 | 1.92e+00 | 0.5336 |
156 | GRK2 | HCC2 | Human | Liver | HCC | 5.24e-16 | 1.94e+00 | 0.5341 |
156 | GRK2 | HCC5 | Human | Liver | HCC | 1.52e-04 | 1.66e+00 | 0.4932 |
156 | GRK2 | S014 | Human | Liver | HCC | 1.31e-22 | 6.51e-01 | 0.2254 |
156 | GRK2 | S015 | Human | Liver | HCC | 3.32e-18 | 5.70e-01 | 0.2375 |
156 | GRK2 | S016 | Human | Liver | HCC | 6.76e-21 | 6.25e-01 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0051701 | Colorectum | AD | biological process involved in interaction with host | 73/3918 | 203/18723 | 5.08e-07 | 1.88e-05 | 73 |
GO:0043112 | Colorectum | AD | receptor metabolic process | 62/3918 | 166/18723 | 8.18e-07 | 2.85e-05 | 62 |
GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
GO:0052126 | Colorectum | AD | movement in host environment | 63/3918 | 175/18723 | 2.85e-06 | 8.11e-05 | 63 |
GO:0046718 | Colorectum | AD | viral entry into host cell | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:0044409 | Colorectum | AD | entry into host | 51/3918 | 151/18723 | 1.60e-04 | 2.21e-03 | 51 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0090257 | Colorectum | AD | regulation of muscle system process | 73/3918 | 252/18723 | 1.46e-03 | 1.24e-02 | 73 |
GO:0018105 | Colorectum | AD | peptidyl-serine phosphorylation | 88/3918 | 315/18723 | 1.73e-03 | 1.43e-02 | 88 |
GO:0018210 | Colorectum | AD | peptidyl-threonine modification | 40/3918 | 125/18723 | 2.44e-03 | 1.88e-02 | 40 |
GO:0018209 | Colorectum | AD | peptidyl-serine modification | 92/3918 | 338/18723 | 3.19e-03 | 2.36e-02 | 92 |
GO:0018107 | Colorectum | AD | peptidyl-threonine phosphorylation | 37/3918 | 116/18723 | 3.68e-03 | 2.61e-02 | 37 |
GO:0031623 | Colorectum | AD | receptor internalization | 35/3918 | 113/18723 | 7.72e-03 | 4.66e-02 | 35 |
GO:00160321 | Colorectum | SER | viral process | 118/2897 | 415/18723 | 8.36e-12 | 1.65e-09 | 118 |
GO:00190581 | Colorectum | SER | viral life cycle | 87/2897 | 317/18723 | 2.82e-08 | 1.94e-06 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRK2 | SNV | Missense_Mutation | c.355G>A | p.Ala119Thr | p.A119T | P25098 | protein_coding | tolerated(0.1) | benign(0.019) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GRK2 | SNV | Missense_Mutation | c.455N>T | p.Glu152Val | p.E152V | P25098 | protein_coding | tolerated(0.34) | benign(0.158) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GRK2 | SNV | Missense_Mutation | rs781246400 | c.676N>T | p.Arg226Cys | p.R226C | P25098 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GRK2 | SNV | Missense_Mutation | novel | c.1948G>A | p.Ala650Thr | p.A650T | P25098 | protein_coding | tolerated(0.83) | benign(0.018) | TCGA-F1-A448-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR |
GRK2 | SNV | Missense_Mutation | rs765668445 | c.1541N>T | p.Ser514Leu | p.S514L | P25098 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | US9493490, L | |||
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | inhibitor | 405560387 | ||
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | inhibitor | 249565822 | BALANOL | |
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | US9493490, E | |||
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | US9493490, C | |||
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | inhibitor | 249565823 | ||
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | BDBM50173306 | |||
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | inhibitor | 252166647 | ||
156 | GRK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR, G PROTEIN COUPLED RECEPTOR, ENZYME | US9493490, D |
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