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Gene: GNL2 |
Gene summary for GNL2 |
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Gene information | Species | Human | Gene symbol | GNL2 | Gene ID | 29889 |
Gene name | G protein nucleolar 2 | |
Gene Alias | HUMAUANTIG | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q13823 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29889 | GNL2 | LZE2T | Human | Esophagus | ESCC | 2.43e-02 | 1.31e-01 | 0.082 |
29889 | GNL2 | LZE4T | Human | Esophagus | ESCC | 6.04e-12 | 9.51e-02 | 0.0811 |
29889 | GNL2 | LZE7T | Human | Esophagus | ESCC | 1.69e-06 | 4.54e-01 | 0.0667 |
29889 | GNL2 | LZE8T | Human | Esophagus | ESCC | 4.67e-11 | 2.02e-01 | 0.067 |
29889 | GNL2 | LZE20T | Human | Esophagus | ESCC | 1.81e-06 | 1.10e-01 | 0.0662 |
29889 | GNL2 | LZE22T | Human | Esophagus | ESCC | 6.32e-03 | 1.31e-01 | 0.068 |
29889 | GNL2 | LZE24T | Human | Esophagus | ESCC | 6.88e-14 | 3.40e-01 | 0.0596 |
29889 | GNL2 | LZE6T | Human | Esophagus | ESCC | 6.62e-04 | 1.51e-01 | 0.0845 |
29889 | GNL2 | P1T-E | Human | Esophagus | ESCC | 1.38e-09 | 3.54e-01 | 0.0875 |
29889 | GNL2 | P2T-E | Human | Esophagus | ESCC | 8.08e-26 | 5.78e-01 | 0.1177 |
29889 | GNL2 | P4T-E | Human | Esophagus | ESCC | 1.83e-09 | 2.06e-01 | 0.1323 |
29889 | GNL2 | P5T-E | Human | Esophagus | ESCC | 2.74e-19 | 3.01e-01 | 0.1327 |
29889 | GNL2 | P8T-E | Human | Esophagus | ESCC | 7.25e-12 | 1.73e-01 | 0.0889 |
29889 | GNL2 | P9T-E | Human | Esophagus | ESCC | 2.71e-11 | 8.90e-02 | 0.1131 |
29889 | GNL2 | P10T-E | Human | Esophagus | ESCC | 1.87e-17 | 3.75e-01 | 0.116 |
29889 | GNL2 | P11T-E | Human | Esophagus | ESCC | 8.44e-10 | 5.86e-01 | 0.1426 |
29889 | GNL2 | P12T-E | Human | Esophagus | ESCC | 4.78e-16 | 2.87e-01 | 0.1122 |
29889 | GNL2 | P15T-E | Human | Esophagus | ESCC | 1.28e-25 | 4.26e-01 | 0.1149 |
29889 | GNL2 | P16T-E | Human | Esophagus | ESCC | 4.16e-23 | 2.54e-01 | 0.1153 |
29889 | GNL2 | P17T-E | Human | Esophagus | ESCC | 3.97e-08 | 4.72e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:002261329 | Skin | cSCC | ribonucleoprotein complex biogenesis | 302/4864 | 463/18723 | 5.13e-72 | 3.22e-68 | 302 |
GO:004225428 | Skin | cSCC | ribosome biogenesis | 206/4864 | 299/18723 | 3.33e-55 | 1.04e-51 | 206 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNL2 | SNV | Missense_Mutation | novel | c.1820N>G | p.Tyr607Cys | p.Y607C | Q13823 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNL2 | SNV | Missense_Mutation | novel | c.1819N>C | p.Tyr607His | p.Y607H | Q13823 | protein_coding | tolerated(0.13) | possibly_damaging(0.801) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNL2 | SNV | Missense_Mutation | novel | c.1258N>A | p.Asp420Asn | p.D420N | Q13823 | protein_coding | deleterious(0.04) | possibly_damaging(0.464) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNL2 | SNV | Missense_Mutation | novel | c.1893G>T | p.Lys631Asn | p.K631N | Q13823 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
GNL2 | SNV | Missense_Mutation | novel | c.145C>T | p.Arg49Cys | p.R49C | Q13823 | protein_coding | tolerated(0.06) | probably_damaging(0.978) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
GNL2 | deletion | Frame_Shift_Del | rs780053113 | c.1414delC | p.Gln472SerfsTer140 | p.Q472Sfs*140 | Q13823 | protein_coding | TCGA-DF-A2KZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GNL2 | SNV | Missense_Mutation | c.1580C>A | p.Thr527Lys | p.T527K | Q13823 | protein_coding | tolerated(0.55) | benign(0) | TCGA-CC-5262-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GNL2 | SNV | Missense_Mutation | c.1988N>A | p.Arg663Lys | p.R663K | Q13823 | protein_coding | tolerated(0.67) | benign(0) | TCGA-DD-A3A9-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
GNL2 | SNV | Missense_Mutation | rs754672713 | c.427N>G | p.Thr143Ala | p.T143A | Q13823 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
GNL2 | SNV | Missense_Mutation | novel | c.1628N>T | p.Ser543Phe | p.S543F | Q13823 | protein_coding | tolerated(0.11) | possibly_damaging(0.646) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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