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Gene: GLB1 |
Gene summary for GLB1 |
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Gene information | Species | Human | Gene symbol | GLB1 | Gene ID | 2720 |
Gene name | galactosidase beta 1 | |
Gene Alias | EBP | |
Cytomap | 3p22.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | P16278 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2720 | GLB1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.49e-09 | 4.47e-01 | -0.1954 |
2720 | GLB1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.70e-02 | 3.09e-01 | -0.1464 |
2720 | GLB1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.41e-07 | 5.12e-01 | 0.096 |
2720 | GLB1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.32e-03 | 3.74e-01 | 0.294 |
2720 | GLB1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.33e-19 | 7.58e-01 | 0.3859 |
2720 | GLB1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.70e-05 | 3.48e-01 | 0.3005 |
2720 | GLB1 | A015-C-203 | Human | Colorectum | FAP | 2.81e-04 | -1.23e-01 | -0.1294 |
2720 | GLB1 | A002-C-201 | Human | Colorectum | FAP | 2.43e-02 | -1.42e-01 | 0.0324 |
2720 | GLB1 | A002-C-205 | Human | Colorectum | FAP | 1.03e-03 | -7.54e-02 | -0.1236 |
2720 | GLB1 | A015-C-006 | Human | Colorectum | FAP | 1.16e-02 | -1.01e-01 | -0.0994 |
2720 | GLB1 | A015-C-106 | Human | Colorectum | FAP | 1.03e-02 | -9.05e-02 | -0.0511 |
2720 | GLB1 | A002-C-114 | Human | Colorectum | FAP | 3.59e-03 | -1.13e-01 | -0.1561 |
2720 | GLB1 | A015-C-104 | Human | Colorectum | FAP | 1.34e-04 | -1.70e-01 | -0.1899 |
2720 | GLB1 | A002-C-016 | Human | Colorectum | FAP | 5.74e-05 | -1.45e-01 | 0.0521 |
2720 | GLB1 | A015-C-002 | Human | Colorectum | FAP | 1.82e-02 | -2.20e-01 | -0.0763 |
2720 | GLB1 | A002-C-116 | Human | Colorectum | FAP | 1.21e-05 | -1.27e-01 | -0.0452 |
2720 | GLB1 | A014-C-008 | Human | Colorectum | FAP | 1.26e-02 | -1.80e-01 | -0.191 |
2720 | GLB1 | A018-E-020 | Human | Colorectum | FAP | 3.65e-03 | -8.61e-02 | -0.2034 |
2720 | GLB1 | CRC-3-11773 | Human | Colorectum | CRC | 1.52e-02 | -6.37e-02 | 0.2564 |
2720 | GLB1 | LZE4T | Human | Esophagus | ESCC | 4.67e-04 | 2.13e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0016052 | Colorectum | AD | carbohydrate catabolic process | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:1901654 | Colorectum | AD | response to ketone | 59/3918 | 194/18723 | 1.14e-03 | 1.04e-02 | 59 |
GO:0097305 | Colorectum | AD | response to alcohol | 71/3918 | 253/18723 | 4.01e-03 | 2.80e-02 | 71 |
GO:0019320 | Colorectum | AD | hexose catabolic process | 14/3918 | 34/18723 | 5.86e-03 | 3.69e-02 | 14 |
GO:0006012 | Colorectum | AD | galactose metabolic process | 6/3918 | 10/18723 | 8.03e-03 | 4.73e-02 | 6 |
GO:00485452 | Colorectum | MSS | response to steroid hormone | 101/3467 | 339/18723 | 2.60e-07 | 1.10e-05 | 101 |
GO:19016542 | Colorectum | MSS | response to ketone | 58/3467 | 194/18723 | 7.70e-05 | 1.28e-03 | 58 |
GO:00160522 | Colorectum | MSS | carbohydrate catabolic process | 45/3467 | 154/18723 | 7.93e-04 | 8.36e-03 | 45 |
GO:00442822 | Colorectum | MSS | small molecule catabolic process | 94/3467 | 376/18723 | 9.85e-04 | 9.86e-03 | 94 |
GO:00193182 | Colorectum | MSS | hexose metabolic process | 63/3467 | 237/18723 | 1.32e-03 | 1.25e-02 | 63 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00973051 | Colorectum | MSS | response to alcohol | 66/3467 | 253/18723 | 1.73e-03 | 1.54e-02 | 66 |
GO:00059962 | Colorectum | MSS | monosaccharide metabolic process | 66/3467 | 257/18723 | 2.61e-03 | 2.06e-02 | 66 |
GO:00060121 | Colorectum | MSS | galactose metabolic process | 6/3467 | 10/18723 | 4.25e-03 | 3.04e-02 | 6 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00052 | Colorectum | FAP | Galactose metabolism | 12/1404 | 32/8465 | 3.61e-03 | 1.53e-02 | 9.29e-03 | 12 |
hsa000521 | Colorectum | FAP | Galactose metabolism | 12/1404 | 32/8465 | 3.61e-03 | 1.53e-02 | 9.29e-03 | 12 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa006003 | Esophagus | ESCC | Sphingolipid metabolism | 36/4205 | 53/8465 | 5.41e-03 | 1.36e-02 | 6.99e-03 | 36 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0060012 | Esophagus | ESCC | Sphingolipid metabolism | 36/4205 | 53/8465 | 5.41e-03 | 1.36e-02 | 6.99e-03 | 36 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa00511 | Liver | HCC | Other glycan degradation | 15/4020 | 18/8465 | 1.96e-03 | 6.91e-03 | 3.84e-03 | 15 |
hsa00600 | Liver | HCC | Sphingolipid metabolism | 34/4020 | 53/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 34 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa005111 | Liver | HCC | Other glycan degradation | 15/4020 | 18/8465 | 1.96e-03 | 6.91e-03 | 3.84e-03 | 15 |
hsa006001 | Liver | HCC | Sphingolipid metabolism | 34/4020 | 53/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 34 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa006002 | Oral cavity | OSCC | Sphingolipid metabolism | 33/3704 | 53/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 33 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0060011 | Oral cavity | OSCC | Sphingolipid metabolism | 33/3704 | 53/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLB1 | SNV | Missense_Mutation | rs553660803 | c.235N>A | p.Ala79Thr | p.A79T | P16278 | protein_coding | tolerated(0.17) | benign(0.039) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
GLB1 | SNV | Missense_Mutation | rs794727165 | c.1768N>T | p.Arg590Cys | p.R590C | P16278 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-V1-A8WW-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | lhrh | SD |
GLB1 | SNV | Missense_Mutation | rs192732174 | c.442N>T | p.Arg148Cys | p.R148C | P16278 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
GLB1 | SNV | Missense_Mutation | rs780523881 | c.146G>A | p.Arg49His | p.R49H | P16278 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GLB1 | SNV | Missense_Mutation | c.326G>A | p.Arg109Gln | p.R109Q | P16278 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GLB1 | SNV | Missense_Mutation | rs794727165 | c.1768N>T | p.Arg590Cys | p.R590C | P16278 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
GLB1 | SNV | Missense_Mutation | rs754538192 | c.1997C>T | p.Pro666Leu | p.P666L | P16278 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.859) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
GLB1 | SNV | Missense_Mutation | novel | c.1963A>C | p.Lys655Gln | p.K655Q | P16278 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-VQ-A94T-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
GLB1 | insertion | Frame_Shift_Ins | novel | c.1978_1979insA | p.Arg660LysfsTer62 | p.R660Kfs*62 | P16278 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GLB1 | SNV | Missense_Mutation | novel | c.1237N>G | p.Tyr413Asp | p.Y413D | P16278 | protein_coding | tolerated(0.06) | possibly_damaging(0.745) | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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