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Gene: GDI1 |
Gene summary for GDI1 |
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Gene information | Species | Human | Gene symbol | GDI1 | Gene ID | 2664 |
Gene name | GDP dissociation inhibitor 1 | |
Gene Alias | 1A | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A0S2Z3X8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2664 | GDI1 | LZE2T | Human | Esophagus | ESCC | 1.90e-05 | 6.90e-01 | 0.082 |
2664 | GDI1 | LZE4T | Human | Esophagus | ESCC | 1.36e-24 | 6.77e-01 | 0.0811 |
2664 | GDI1 | LZE5T | Human | Esophagus | ESCC | 4.21e-02 | 3.63e-01 | 0.0514 |
2664 | GDI1 | LZE7T | Human | Esophagus | ESCC | 5.46e-32 | 1.44e+00 | 0.0667 |
2664 | GDI1 | LZE8T | Human | Esophagus | ESCC | 3.62e-09 | 3.44e-01 | 0.067 |
2664 | GDI1 | LZE20T | Human | Esophagus | ESCC | 1.99e-15 | 4.24e-01 | 0.0662 |
2664 | GDI1 | LZE22T | Human | Esophagus | ESCC | 4.54e-09 | 7.28e-01 | 0.068 |
2664 | GDI1 | LZE24T | Human | Esophagus | ESCC | 2.10e-51 | 1.18e+00 | 0.0596 |
2664 | GDI1 | LZE21T | Human | Esophagus | ESCC | 6.27e-09 | 6.80e-01 | 0.0655 |
2664 | GDI1 | LZE6T | Human | Esophagus | ESCC | 3.59e-09 | 4.02e-01 | 0.0845 |
2664 | GDI1 | P1T-E | Human | Esophagus | ESCC | 1.04e-27 | 1.12e+00 | 0.0875 |
2664 | GDI1 | P2T-E | Human | Esophagus | ESCC | 1.54e-46 | 8.06e-01 | 0.1177 |
2664 | GDI1 | P4T-E | Human | Esophagus | ESCC | 1.04e-34 | 7.76e-01 | 0.1323 |
2664 | GDI1 | P5T-E | Human | Esophagus | ESCC | 8.64e-41 | 7.50e-01 | 0.1327 |
2664 | GDI1 | P8T-E | Human | Esophagus | ESCC | 1.87e-34 | 5.93e-01 | 0.0889 |
2664 | GDI1 | P9T-E | Human | Esophagus | ESCC | 1.14e-40 | 8.08e-01 | 0.1131 |
2664 | GDI1 | P10T-E | Human | Esophagus | ESCC | 2.93e-74 | 1.36e+00 | 0.116 |
2664 | GDI1 | P11T-E | Human | Esophagus | ESCC | 2.51e-35 | 1.11e+00 | 0.1426 |
2664 | GDI1 | P12T-E | Human | Esophagus | ESCC | 9.42e-55 | 1.02e+00 | 0.1122 |
2664 | GDI1 | P15T-E | Human | Esophagus | ESCC | 1.47e-44 | 7.56e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:190547519 | Esophagus | ESCC | regulation of protein localization to membrane | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:190353315 | Esophagus | ESCC | regulation of protein targeting | 57/8552 | 81/18723 | 5.83e-06 | 6.03e-05 | 57 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:19038289 | Esophagus | ESCC | negative regulation of cellular protein localization | 76/8552 | 117/18723 | 1.97e-05 | 1.72e-04 | 76 |
GO:00066124 | Esophagus | ESCC | protein targeting to membrane | 83/8552 | 131/18723 | 3.31e-05 | 2.73e-04 | 83 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00507697 | Esophagus | ESCC | positive regulation of neurogenesis | 131/8552 | 225/18723 | 9.71e-05 | 6.90e-04 | 131 |
GO:003030710 | Esophagus | ESCC | positive regulation of cell growth | 100/8552 | 166/18723 | 1.07e-04 | 7.55e-04 | 100 |
GO:00083619 | Esophagus | ESCC | regulation of cell size | 107/8552 | 181/18723 | 1.81e-04 | 1.16e-03 | 107 |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GDI1 | SNV | Missense_Mutation | c.802N>A | p.Val268Met | p.V268M | P31150 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-39-5036-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GDI1 | SNV | Missense_Mutation | novel | c.328N>A | p.Val110Ile | p.V110I | P31150 | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GDI1 | SNV | Missense_Mutation | novel | c.940N>T | p.Ala314Ser | p.A314S | P31150 | protein_coding | tolerated(0.7) | benign(0.27) | TCGA-63-7022-01 | Lung | lung squamous cell carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
GDI1 | SNV | Missense_Mutation | novel | c.259N>G | p.Leu87Val | p.L87V | P31150 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GDI1 | SNV | Missense_Mutation | novel | c.693N>T | p.Leu231Phe | p.L231F | P31150 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
GDI1 | SNV | Missense_Mutation | novel | c.896N>A | p.Arg299His | p.R299H | P31150 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CN-6018-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GDI1 | SNV | Missense_Mutation | novel | c.304N>G | p.Phe102Val | p.F102V | P31150 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-CV-6939-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
GDI1 | SNV | Missense_Mutation | novel | c.1033G>T | p.Ala345Ser | p.A345S | P31150 | protein_coding | tolerated(0.34) | benign(0.076) | TCGA-TN-A7HJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
GDI1 | SNV | Missense_Mutation | novel | c.796N>A | p.Val266Met | p.V266M | P31150 | protein_coding | deleterious(0.04) | benign(0.421) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
GDI1 | SNV | Missense_Mutation | novel | c.880N>C | p.Ala294Pro | p.A294P | P31150 | protein_coding | deleterious(0.01) | benign(0.1) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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