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Gene: GAD1 |
Gene summary for GAD1 |
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Gene information | Species | Human | Gene symbol | GAD1 | Gene ID | 2571 |
Gene name | glutamate decarboxylase 1 | |
Gene Alias | CPSQ1 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | A0A0S2Z3V5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2571 | GAD1 | P2T-E | Human | Esophagus | ESCC | 4.75e-06 | 1.10e-01 | 0.1177 |
2571 | GAD1 | P4T-E | Human | Esophagus | ESCC | 9.91e-08 | 2.32e-01 | 0.1323 |
2571 | GAD1 | P8T-E | Human | Esophagus | ESCC | 3.04e-07 | 2.66e-01 | 0.0889 |
2571 | GAD1 | P10T-E | Human | Esophagus | ESCC | 3.05e-25 | 4.04e-01 | 0.116 |
2571 | GAD1 | P11T-E | Human | Esophagus | ESCC | 2.46e-02 | 2.13e-01 | 0.1426 |
2571 | GAD1 | P16T-E | Human | Esophagus | ESCC | 1.63e-02 | 5.33e-02 | 0.1153 |
2571 | GAD1 | P21T-E | Human | Esophagus | ESCC | 2.24e-11 | 1.81e-01 | 0.1617 |
2571 | GAD1 | P22T-E | Human | Esophagus | ESCC | 1.75e-04 | 4.94e-02 | 0.1236 |
2571 | GAD1 | P23T-E | Human | Esophagus | ESCC | 6.53e-09 | 2.47e-01 | 0.108 |
2571 | GAD1 | P26T-E | Human | Esophagus | ESCC | 3.01e-13 | 4.09e-01 | 0.1276 |
2571 | GAD1 | P27T-E | Human | Esophagus | ESCC | 7.32e-03 | 6.73e-02 | 0.1055 |
2571 | GAD1 | P49T-E | Human | Esophagus | ESCC | 1.17e-11 | 9.31e-01 | 0.1768 |
2571 | GAD1 | P57T-E | Human | Esophagus | ESCC | 5.02e-04 | 2.51e-01 | 0.0926 |
2571 | GAD1 | P61T-E | Human | Esophagus | ESCC | 2.55e-05 | 1.47e-01 | 0.099 |
2571 | GAD1 | P62T-E | Human | Esophagus | ESCC | 1.20e-04 | 1.15e-01 | 0.1302 |
2571 | GAD1 | P65T-E | Human | Esophagus | ESCC | 1.10e-13 | 2.86e-01 | 0.0978 |
2571 | GAD1 | P74T-E | Human | Esophagus | ESCC | 1.86e-07 | 2.29e-01 | 0.1479 |
2571 | GAD1 | P75T-E | Human | Esophagus | ESCC | 5.80e-06 | 1.33e-01 | 0.1125 |
2571 | GAD1 | P76T-E | Human | Esophagus | ESCC | 5.90e-05 | 1.35e-01 | 0.1207 |
2571 | GAD1 | P89T-E | Human | Esophagus | ESCC | 4.36e-04 | 2.88e-01 | 0.1752 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:00086525 | Esophagus | ESCC | cellular amino acid biosynthetic process | 51/8552 | 76/18723 | 1.30e-04 | 8.88e-04 | 51 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:00436485 | Esophagus | ESCC | dicarboxylic acid metabolic process | 58/8552 | 96/18723 | 2.55e-03 | 1.09e-02 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GAD1 | SNV | Missense_Mutation | c.692N>T | p.Lys231Met | p.K231M | Q99259 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GAD1 | SNV | Missense_Mutation | c.1345G>T | p.Gly449Trp | p.G449W | Q99259 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD | |
GAD1 | SNV | Missense_Mutation | c.699N>C | p.Met233Ile | p.M233I | Q99259 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-55-7570-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GAD1 | SNV | Missense_Mutation | c.1495N>A | p.Glu499Lys | p.E499K | Q99259 | protein_coding | tolerated(0.14) | benign(0.267) | TCGA-62-A471-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
GAD1 | SNV | Missense_Mutation | c.1567N>T | p.Arg523Trp | p.R523W | Q99259 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GAD1 | SNV | Missense_Mutation | c.713N>A | p.Gly238Glu | p.G238E | Q99259 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GAD1 | SNV | Missense_Mutation | rs150945113 | c.400C>T | p.Arg134Cys | p.R134C | Q99259 | protein_coding | deleterious(0.02) | possibly_damaging(0.875) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GAD1 | SNV | Missense_Mutation | c.1630G>A | p.Ala544Thr | p.A544T | Q99259 | protein_coding | tolerated(0.07) | benign(0.427) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GAD1 | SNV | Missense_Mutation | c.557N>A | p.Arg186Gln | p.R186Q | Q99259 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GAD1 | SNV | Missense_Mutation | novel | c.791G>A | p.Arg264His | p.R264H | Q99259 | protein_coding | deleterious(0.01) | probably_damaging(0.944) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2571 | GAD1 | DRUGGABLE GENOME, ENZYME | inhibitor | 178101950 | ||
2571 | GAD1 | DRUGGABLE GENOME, ENZYME | methadone | METHADONE | 31866536 |
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