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Gene: FBXL13 |
Gene summary for FBXL13 |
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Gene information | Species | Human | Gene symbol | FBXL13 | Gene ID | 222235 |
Gene name | F-box and leucine rich repeat protein 13 | |
Gene Alias | CFAP169 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8N1P0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222235 | FBXL13 | P2T-E | Human | Esophagus | ESCC | 1.92e-37 | 6.09e-01 | 0.1177 |
222235 | FBXL13 | P27T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.14e-01 | 0.1055 |
222235 | FBXL13 | P56T-E | Human | Esophagus | ESCC | 1.16e-08 | 9.98e-01 | 0.1613 |
222235 | FBXL13 | P80T-E | Human | Esophagus | ESCC | 1.97e-04 | 1.73e-01 | 0.155 |
222235 | FBXL13 | P128T-E | Human | Esophagus | ESCC | 9.55e-03 | 1.21e-01 | 0.1241 |
222235 | FBXL13 | HCC1 | Human | Liver | HCC | 8.15e-10 | 1.23e+00 | 0.5336 |
222235 | FBXL13 | HCC2 | Human | Liver | HCC | 5.53e-16 | 1.75e+00 | 0.5341 |
222235 | FBXL13 | HCC5 | Human | Liver | HCC | 4.93e-04 | 9.36e-01 | 0.4932 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:00311461 | Esophagus | ESCC | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 33/8552 | 49/18723 | 1.80e-03 | 8.26e-03 | 33 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:0031146 | Liver | HCC | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXL13 | SNV | Missense_Mutation | novel | c.198N>A | p.Asp66Glu | p.D66E | Q8NEE6 | protein_coding | tolerated(0.61) | benign(0.001) | TCGA-21-5783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FBXL13 | SNV | Missense_Mutation | c.1571N>A | p.Gly524Glu | p.G524E | Q8NEE6 | protein_coding | tolerated(1) | benign(0) | TCGA-33-4583-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBXL13 | SNV | Missense_Mutation | novel | c.319G>T | p.Asp107Tyr | p.D107Y | Q8NEE6 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-34-7107-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FBXL13 | SNV | Missense_Mutation | novel | c.17N>C | p.Met6Thr | p.M6T | Q8NEE6 | protein_coding | deleterious(0.04) | possibly_damaging(0.521) | TCGA-63-A5MR-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FBXL13 | SNV | Missense_Mutation | c.71C>G | p.Thr24Ser | p.T24S | Q8NEE6 | protein_coding | tolerated(0.22) | benign(0.052) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
FBXL13 | SNV | Missense_Mutation | novel | c.324N>C | p.Glu108Asp | p.E108D | Q8NEE6 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-98-A538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FBXL13 | SNV | Missense_Mutation | novel | c.1262N>G | p.Ile421Arg | p.I421R | Q8NEE6 | protein_coding | deleterious(0) | benign(0.418) | TCGA-NC-A5HM-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FBXL13 | SNV | Missense_Mutation | c.447N>C | p.Glu149Asp | p.E149D | Q8NEE6 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-BA-4077-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cetuximab | PD | |
FBXL13 | SNV | Missense_Mutation | rs370558905 | c.922N>T | p.Arg308Trp | p.R308W | Q8NEE6 | protein_coding | deleterious(0) | possibly_damaging(0.846) | TCGA-CN-5356-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
FBXL13 | SNV | Missense_Mutation | c.745N>C | p.Glu249Gln | p.E249Q | Q8NEE6 | protein_coding | deleterious(0.01) | probably_damaging(0.924) | TCGA-CQ-7069-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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