![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FAM83C |
Gene summary for FAM83C |
![]() |
Gene information | Species | Human | Gene symbol | FAM83C | Gene ID | 128876 |
Gene name | family with sequence similarity 83 member C | |
Gene Alias | C20orf128 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9BQN1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128876 | FAM83C | LZE24T | Human | Esophagus | ESCC | 5.22e-05 | 5.28e-01 | 0.0596 |
128876 | FAM83C | P1T-E | Human | Esophagus | ESCC | 5.85e-06 | 1.34e-01 | 0.0875 |
128876 | FAM83C | P4T-E | Human | Esophagus | ESCC | 3.35e-08 | 7.13e-02 | 0.1323 |
128876 | FAM83C | P5T-E | Human | Esophagus | ESCC | 1.78e-03 | -2.14e-01 | 0.1327 |
128876 | FAM83C | P8T-E | Human | Esophagus | ESCC | 9.79e-07 | -1.10e-01 | 0.0889 |
128876 | FAM83C | P9T-E | Human | Esophagus | ESCC | 2.75e-13 | -1.21e-02 | 0.1131 |
128876 | FAM83C | P12T-E | Human | Esophagus | ESCC | 3.84e-08 | -1.13e-01 | 0.1122 |
128876 | FAM83C | P15T-E | Human | Esophagus | ESCC | 2.28e-05 | -1.03e-01 | 0.1149 |
128876 | FAM83C | P16T-E | Human | Esophagus | ESCC | 3.75e-03 | -2.14e-01 | 0.1153 |
128876 | FAM83C | P20T-E | Human | Esophagus | ESCC | 2.03e-06 | 9.94e-02 | 0.1124 |
128876 | FAM83C | P21T-E | Human | Esophagus | ESCC | 5.78e-16 | 4.33e-01 | 0.1617 |
128876 | FAM83C | P22T-E | Human | Esophagus | ESCC | 4.11e-07 | -1.25e-01 | 0.1236 |
128876 | FAM83C | P23T-E | Human | Esophagus | ESCC | 8.86e-11 | 1.42e-02 | 0.108 |
128876 | FAM83C | P24T-E | Human | Esophagus | ESCC | 3.80e-05 | -1.67e-01 | 0.1287 |
128876 | FAM83C | P27T-E | Human | Esophagus | ESCC | 3.84e-10 | -7.71e-03 | 0.1055 |
128876 | FAM83C | P28T-E | Human | Esophagus | ESCC | 7.40e-06 | 4.97e-02 | 0.1149 |
128876 | FAM83C | P30T-E | Human | Esophagus | ESCC | 1.90e-04 | -6.67e-02 | 0.137 |
128876 | FAM83C | P31T-E | Human | Esophagus | ESCC | 9.34e-06 | -2.57e-02 | 0.1251 |
128876 | FAM83C | P32T-E | Human | Esophagus | ESCC | 3.78e-02 | -2.10e-01 | 0.1666 |
128876 | FAM83C | P37T-E | Human | Esophagus | ESCC | 1.42e-02 | -2.08e-01 | 0.1371 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM83C | SNV | Missense_Mutation | c.1171N>G | p.Gln391Glu | p.Q391E | Q9BQN1 | protein_coding | tolerated_low_confidence(0.12) | benign(0.027) | TCGA-55-8092-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAM83C | SNV | Missense_Mutation | c.1585N>A | p.Pro529Thr | p.P529T | Q9BQN1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.06) | TCGA-55-8510-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM83C | SNV | Missense_Mutation | rs777921694 | c.736C>T | p.Arg246Cys | p.R246C | Q9BQN1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-55-A492-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM83C | SNV | Missense_Mutation | rs769453860 | c.794C>T | p.Ala265Val | p.A265V | Q9BQN1 | protein_coding | tolerated(0.1) | benign(0.018) | TCGA-71-6725-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
FAM83C | SNV | Missense_Mutation | c.1003G>T | p.Val335Phe | p.V335F | Q9BQN1 | protein_coding | deleterious(0.05) | benign(0.009) | TCGA-73-4666-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
FAM83C | SNV | Missense_Mutation | c.1640N>A | p.Ser547Tyr | p.S547Y | Q9BQN1 | protein_coding | deleterious_low_confidence(0) | benign(0.06) | TCGA-73-4668-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | pemetrexed | PD | |
FAM83C | SNV | Missense_Mutation | c.593N>A | p.Val198Asp | p.V198D | Q9BQN1 | protein_coding | deleterious(0) | possibly_damaging(0.824) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM83C | SNV | Missense_Mutation | novel | c.253G>T | p.Val85Leu | p.V85L | Q9BQN1 | protein_coding | tolerated(0.17) | benign(0.138) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FAM83C | SNV | Missense_Mutation | c.1659N>A | p.Ser553Arg | p.S553R | Q9BQN1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.172) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
FAM83C | SNV | Missense_Mutation | novel | c.1262N>A | p.Pro421Gln | p.P421Q | Q9BQN1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.606) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |