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Gene: FAM214A |
Gene summary for FAM214A |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM214A | Gene ID | 56204 |
Gene name | family with sequence similarity 214 member A | |
Gene Alias | KIAA1370 | |
Cytomap | 15q21.2-q21.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q32MH5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56204 | FAM214A | GSM4909301 | Human | Breast | IDC | 9.32e-04 | 2.81e-01 | 0.1577 |
56204 | FAM214A | GSM4909303 | Human | Breast | IDC | 1.45e-03 | 3.53e-01 | 0.0438 |
56204 | FAM214A | GSM4909304 | Human | Breast | IDC | 1.31e-25 | 5.72e-01 | 0.1636 |
56204 | FAM214A | GSM4909308 | Human | Breast | IDC | 1.96e-03 | 1.75e-01 | 0.158 |
56204 | FAM214A | GSM4909311 | Human | Breast | IDC | 7.38e-05 | -1.06e-01 | 0.1534 |
56204 | FAM214A | GSM4909312 | Human | Breast | IDC | 1.83e-03 | 6.78e-02 | 0.1552 |
56204 | FAM214A | GSM4909319 | Human | Breast | IDC | 7.56e-08 | -1.17e-01 | 0.1563 |
56204 | FAM214A | M5 | Human | Breast | IDC | 3.34e-07 | 7.44e-01 | 0.1598 |
56204 | FAM214A | P1 | Human | Breast | IDC | 1.47e-02 | 7.19e-02 | 0.1527 |
56204 | FAM214A | DCIS2 | Human | Breast | DCIS | 6.19e-40 | 1.11e-01 | 0.0085 |
56204 | FAM214A | CCI_2 | Human | Cervix | CC | 2.09e-06 | 1.04e+00 | 0.5249 |
56204 | FAM214A | CCI_3 | Human | Cervix | CC | 9.20e-03 | 4.01e-01 | 0.516 |
56204 | FAM214A | H2 | Human | Cervix | HSIL_HPV | 1.48e-09 | 5.17e-01 | 0.0632 |
56204 | FAM214A | AEH-subject1 | Human | Endometrium | AEH | 7.38e-08 | 3.91e-01 | -0.3059 |
56204 | FAM214A | AEH-subject2 | Human | Endometrium | AEH | 1.23e-02 | 1.47e-01 | -0.2525 |
56204 | FAM214A | AEH-subject3 | Human | Endometrium | AEH | 2.88e-05 | 3.08e-01 | -0.2576 |
56204 | FAM214A | AEH-subject4 | Human | Endometrium | AEH | 1.50e-12 | 4.69e-01 | -0.2657 |
56204 | FAM214A | AEH-subject5 | Human | Endometrium | AEH | 5.70e-06 | 4.26e-01 | -0.2953 |
56204 | FAM214A | EEC-subject1 | Human | Endometrium | EEC | 1.18e-07 | 3.00e-01 | -0.2682 |
56204 | FAM214A | EEC-subject2 | Human | Endometrium | EEC | 3.43e-02 | 2.43e-01 | -0.2607 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM214A | SNV | Missense_Mutation | rs756780019 | c.3145C>T | p.Arg1049Trp | p.R1049W | Q32MH5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
FAM214A | SNV | Missense_Mutation | c.2223N>A | p.Phe741Leu | p.F741L | Q32MH5 | protein_coding | tolerated(0.16) | benign(0.013) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
FAM214A | SNV | Missense_Mutation | rs549552771 | c.1565N>T | p.Ser522Leu | p.S522L | Q32MH5 | protein_coding | tolerated(0.27) | benign(0.013) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
FAM214A | SNV | Missense_Mutation | novel | c.2912N>A | p.Pro971His | p.P971H | Q32MH5 | protein_coding | deleterious(0.01) | possibly_damaging(0.615) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
FAM214A | SNV | Missense_Mutation | rs372718525 | c.1379G>A | p.Arg460Gln | p.R460Q | Q32MH5 | protein_coding | tolerated_low_confidence(0.35) | benign(0.007) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM214A | SNV | Missense_Mutation | novel | c.227G>A | p.Arg76His | p.R76H | Q32MH5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
FAM214A | SNV | Missense_Mutation | novel | c.2912C>A | p.Pro971His | p.P971H | Q32MH5 | protein_coding | deleterious(0.01) | possibly_damaging(0.615) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
FAM214A | SNV | Missense_Mutation | novel | c.3032N>T | p.Arg1011Ile | p.R1011I | Q32MH5 | protein_coding | tolerated(0.05) | possibly_damaging(0.786) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM214A | SNV | Missense_Mutation | c.113N>A | p.Arg38Gln | p.R38Q | Q32MH5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM214A | SNV | Missense_Mutation | novel | c.1586N>A | p.Arg529Lys | p.R529K | Q32MH5 | protein_coding | tolerated(0.66) | benign(0.049) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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