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Gene: FAM208A |
Gene summary for FAM208A |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM208A | Gene ID | 23272 |
Gene name | transcription activation suppressor | |
Gene Alias | C3orf63 | |
Cytomap | 3p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000578 | UniProtAcc | Q9UK61 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23272 | FAM208A | P1T-E | Human | Esophagus | ESCC | 1.05e-05 | 1.29e-01 | 0.0875 |
23272 | FAM208A | P2T-E | Human | Esophagus | ESCC | 9.57e-33 | 5.79e-01 | 0.1177 |
23272 | FAM208A | P4T-E | Human | Esophagus | ESCC | 3.48e-16 | 3.68e-01 | 0.1323 |
23272 | FAM208A | P5T-E | Human | Esophagus | ESCC | 3.52e-05 | 9.40e-02 | 0.1327 |
23272 | FAM208A | P8T-E | Human | Esophagus | ESCC | 2.87e-14 | 1.57e-01 | 0.0889 |
23272 | FAM208A | P9T-E | Human | Esophagus | ESCC | 4.63e-16 | 1.34e-01 | 0.1131 |
23272 | FAM208A | P10T-E | Human | Esophagus | ESCC | 1.36e-17 | 3.15e-01 | 0.116 |
23272 | FAM208A | P11T-E | Human | Esophagus | ESCC | 4.47e-06 | 2.47e-01 | 0.1426 |
23272 | FAM208A | P12T-E | Human | Esophagus | ESCC | 2.40e-22 | 3.49e-01 | 0.1122 |
23272 | FAM208A | P15T-E | Human | Esophagus | ESCC | 7.46e-09 | 2.66e-01 | 0.1149 |
23272 | FAM208A | P16T-E | Human | Esophagus | ESCC | 4.00e-13 | 2.44e-01 | 0.1153 |
23272 | FAM208A | P17T-E | Human | Esophagus | ESCC | 2.44e-09 | 3.81e-01 | 0.1278 |
23272 | FAM208A | P20T-E | Human | Esophagus | ESCC | 7.75e-18 | 2.89e-01 | 0.1124 |
23272 | FAM208A | P21T-E | Human | Esophagus | ESCC | 8.03e-26 | 5.06e-01 | 0.1617 |
23272 | FAM208A | P22T-E | Human | Esophagus | ESCC | 9.81e-18 | 3.53e-01 | 0.1236 |
23272 | FAM208A | P23T-E | Human | Esophagus | ESCC | 2.92e-16 | 4.34e-01 | 0.108 |
23272 | FAM208A | P24T-E | Human | Esophagus | ESCC | 1.23e-18 | 2.98e-01 | 0.1287 |
23272 | FAM208A | P26T-E | Human | Esophagus | ESCC | 1.18e-18 | 3.99e-01 | 0.1276 |
23272 | FAM208A | P27T-E | Human | Esophagus | ESCC | 2.32e-14 | 2.88e-01 | 0.1055 |
23272 | FAM208A | P28T-E | Human | Esophagus | ESCC | 3.71e-11 | 1.93e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM208A | SNV | Missense_Mutation | c.327N>T | p.Lys109Asn | p.K109N | Q9UK61 | protein_coding | deleterious(0.02) | benign(0.009) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM208A | SNV | Missense_Mutation | c.2641N>G | p.Asn881Asp | p.N881D | Q9UK61 | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM208A | SNV | Missense_Mutation | c.4325A>G | p.Asn1442Ser | p.N1442S | Q9UK61 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM208A | SNV | Missense_Mutation | c.2344G>A | p.Ala782Thr | p.A782T | Q9UK61 | protein_coding | tolerated(0.22) | benign(0.406) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
FAM208A | SNV | Missense_Mutation | c.2086G>A | p.Gly696Ser | p.G696S | Q9UK61 | protein_coding | tolerated(0.07) | benign(0.254) | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM208A | SNV | Missense_Mutation | novel | c.2079G>T | p.Lys693Asn | p.K693N | Q9UK61 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
FAM208A | SNV | Missense_Mutation | c.3761N>C | p.Lys1254Thr | p.K1254T | Q9UK61 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM208A | SNV | Missense_Mutation | novel | c.3117N>T | p.Lys1039Asn | p.K1039N | Q9UK61 | protein_coding | tolerated(0.1) | benign(0.019) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM208A | SNV | Missense_Mutation | novel | c.2780N>A | p.Ser927Asn | p.S927N | Q9UK61 | protein_coding | tolerated(0.16) | benign(0.061) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM208A | SNV | Missense_Mutation | rs766983325 | c.1691N>A | p.Arg564Gln | p.R564Q | Q9UK61 | protein_coding | deleterious(0.01) | possibly_damaging(0.576) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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