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Gene: FAM172A |
Gene summary for FAM172A |
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Gene information | Species | Human | Gene symbol | FAM172A | Gene ID | 83989 |
Gene name | family with sequence similarity 172 member A | |
Gene Alias | C5orf21 | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q8WUF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83989 | FAM172A | CCI_1 | Human | Cervix | CC | 1.35e-02 | 5.34e-01 | 0.528 |
83989 | FAM172A | CCI_2 | Human | Cervix | CC | 1.76e-10 | 1.19e+00 | 0.5249 |
83989 | FAM172A | CCI_3 | Human | Cervix | CC | 1.41e-10 | 8.32e-01 | 0.516 |
83989 | FAM172A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.71e-21 | -7.44e-01 | 0.0155 |
83989 | FAM172A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.85e-02 | -4.40e-01 | -0.1808 |
83989 | FAM172A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.12e-04 | -6.31e-01 | -0.1207 |
83989 | FAM172A | HTA11_696_2000001011 | Human | Colorectum | AD | 3.04e-08 | -4.38e-01 | -0.1464 |
83989 | FAM172A | HTA11_866_2000001011 | Human | Colorectum | AD | 4.44e-03 | -3.45e-01 | -0.1001 |
83989 | FAM172A | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.12e-02 | -8.34e-01 | 0.0451 |
83989 | FAM172A | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.05e-05 | 5.93e-01 | 0.0588 |
83989 | FAM172A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.08e-05 | 5.71e-01 | 0.281 |
83989 | FAM172A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.09e-02 | 5.94e-01 | 0.3859 |
83989 | FAM172A | A001-C-207 | Human | Colorectum | FAP | 2.22e-03 | -2.87e-01 | 0.1278 |
83989 | FAM172A | A015-C-203 | Human | Colorectum | FAP | 4.78e-32 | -4.54e-01 | -0.1294 |
83989 | FAM172A | A015-C-204 | Human | Colorectum | FAP | 2.82e-06 | -3.77e-01 | -0.0228 |
83989 | FAM172A | A014-C-040 | Human | Colorectum | FAP | 8.36e-05 | -3.94e-01 | -0.1184 |
83989 | FAM172A | A002-C-201 | Human | Colorectum | FAP | 5.82e-16 | -4.62e-01 | 0.0324 |
83989 | FAM172A | A001-C-119 | Human | Colorectum | FAP | 5.72e-13 | -7.25e-01 | -0.1557 |
83989 | FAM172A | A001-C-108 | Human | Colorectum | FAP | 3.77e-16 | -3.73e-01 | -0.0272 |
83989 | FAM172A | A002-C-205 | Human | Colorectum | FAP | 1.76e-23 | -4.54e-01 | -0.1236 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004348410 | Cervix | CC | regulation of RNA splicing | 42/2311 | 148/18723 | 1.25e-07 | 6.24e-06 | 42 |
GO:19033119 | Cervix | CC | regulation of mRNA metabolic process | 64/2311 | 288/18723 | 1.71e-06 | 5.64e-05 | 64 |
GO:004802410 | Cervix | CC | regulation of mRNA splicing, via spliceosome | 28/2311 | 101/18723 | 2.41e-05 | 4.19e-04 | 28 |
GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00506849 | Cervix | CC | regulation of mRNA processing | 33/2311 | 137/18723 | 1.06e-04 | 1.35e-03 | 33 |
GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
GO:000037710 | Cervix | CC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 55/2311 | 320/18723 | 6.71e-03 | 3.70e-02 | 55 |
GO:000039810 | Cervix | CC | mRNA splicing, via spliceosome | 55/2311 | 320/18723 | 6.71e-03 | 3.70e-02 | 55 |
GO:000037510 | Cervix | CC | RNA splicing, via transesterification reactions | 55/2311 | 324/18723 | 8.61e-03 | 4.44e-02 | 55 |
GO:00487624 | Cervix | CC | mesenchymal cell differentiation | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0043484 | Colorectum | AD | regulation of RNA splicing | 70/3918 | 148/18723 | 6.47e-13 | 1.16e-10 | 70 |
GO:0048024 | Colorectum | AD | regulation of mRNA splicing, via spliceosome | 50/3918 | 101/18723 | 1.62e-10 | 1.56e-08 | 50 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:0000380 | Colorectum | AD | alternative mRNA splicing, via spliceosome | 33/3918 | 77/18723 | 1.13e-05 | 2.55e-04 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM172A | insertion | Nonsense_Mutation | novel | c.669_670insTAAAAAAATTAATATTCTT | p.Ala224Ter | p.A224* | Q8WUF8 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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