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Gene: ELMO1 |
Gene summary for ELMO1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ELMO1 | Gene ID | 9844 |
Gene name | engulfment and cell motility 1 | |
Gene Alias | CED-12 | |
Cytomap | 7p14.2-p14.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q92556 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9844 | ELMO1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.99e-12 | 4.28e-01 | -0.1954 |
9844 | ELMO1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.11e-04 | 2.97e-01 | -0.1207 |
9844 | ELMO1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.16e-19 | 4.29e-01 | -0.1464 |
9844 | ELMO1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.48e-05 | 3.00e-01 | -0.0842 |
9844 | ELMO1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.06e-13 | 4.00e-01 | 0.0674 |
9844 | ELMO1 | A002-C-010 | Human | Colorectum | FAP | 1.02e-33 | 9.15e-01 | 0.242 |
9844 | ELMO1 | A001-C-207 | Human | Colorectum | FAP | 3.80e-02 | 3.16e-01 | 0.1278 |
9844 | ELMO1 | A002-C-201 | Human | Colorectum | FAP | 1.39e-06 | 4.69e-01 | 0.0324 |
9844 | ELMO1 | A002-C-203 | Human | Colorectum | FAP | 2.24e-39 | 1.03e+00 | 0.2786 |
9844 | ELMO1 | A002-C-021 | Human | Colorectum | FAP | 2.74e-35 | 6.88e-01 | 0.1171 |
9844 | ELMO1 | A014-C-108 | Human | Colorectum | FAP | 7.72e-06 | 3.57e-01 | -0.124 |
9844 | ELMO1 | A001-C-104 | Human | Colorectum | FAP | 5.51e-04 | 2.95e-01 | 0.0184 |
9844 | ELMO1 | A015-C-202 | Human | Colorectum | FAP | 8.01e-15 | 4.25e-01 | -0.0849 |
9844 | ELMO1 | A002-C-016 | Human | Colorectum | FAP | 2.95e-12 | 5.72e-01 | 0.0521 |
9844 | ELMO1 | A002-C-116 | Human | Colorectum | FAP | 4.62e-05 | 4.04e-01 | -0.0452 |
9844 | ELMO1 | A008-E-015 | Human | Colorectum | FAP | 1.99e-26 | 6.62e-01 | 0.0177 |
9844 | ELMO1 | AEH-subject4 | Human | Endometrium | AEH | 1.17e-16 | 4.34e-01 | -0.2657 |
9844 | ELMO1 | AEH-subject5 | Human | Endometrium | AEH | 3.30e-05 | 1.92e-01 | -0.2953 |
9844 | ELMO1 | EEC-subject4 | Human | Endometrium | EEC | 4.01e-02 | 1.50e-01 | -0.2571 |
9844 | ELMO1 | LZE4T | Human | Esophagus | ESCC | 1.20e-04 | 1.60e-01 | 0.0811 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0016601 | Colorectum | AD | Rac protein signal transduction | 20/3918 | 42/18723 | 1.02e-04 | 1.53e-03 | 20 |
GO:00070154 | Colorectum | FAP | actin filament organization | 125/2622 | 442/18723 | 1.97e-15 | 3.03e-12 | 125 |
GO:00072652 | Colorectum | FAP | Ras protein signal transduction | 80/2622 | 337/18723 | 9.61e-07 | 4.33e-05 | 80 |
GO:00166012 | Colorectum | FAP | Rac protein signal transduction | 14/2622 | 42/18723 | 1.20e-03 | 1.14e-02 | 14 |
GO:000701516 | Endometrium | AEH | actin filament organization | 98/2100 | 442/18723 | 1.99e-11 | 2.98e-09 | 98 |
GO:00072657 | Endometrium | AEH | Ras protein signal transduction | 63/2100 | 337/18723 | 3.09e-05 | 5.66e-04 | 63 |
GO:00166016 | Endometrium | AEH | Rac protein signal transduction | 11/2100 | 42/18723 | 5.45e-03 | 3.37e-02 | 11 |
GO:000701517 | Endometrium | EEC | actin filament organization | 95/2168 | 442/18723 | 1.31e-09 | 1.09e-07 | 95 |
GO:000726513 | Endometrium | EEC | Ras protein signal transduction | 64/2168 | 337/18723 | 4.31e-05 | 7.10e-04 | 64 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:00166019 | Esophagus | ESCC | Rac protein signal transduction | 33/8552 | 42/18723 | 1.35e-05 | 1.23e-04 | 33 |
GO:00072654 | Liver | NAFLD | Ras protein signal transduction | 66/1882 | 337/18723 | 8.43e-08 | 7.09e-06 | 66 |
GO:00070157 | Liver | NAFLD | actin filament organization | 78/1882 | 442/18723 | 5.44e-07 | 3.21e-05 | 78 |
GO:00166014 | Liver | NAFLD | Rac protein signal transduction | 11/1882 | 42/18723 | 2.32e-03 | 2.19e-02 | 11 |
GO:000701512 | Liver | Cirrhotic | actin filament organization | 171/4634 | 442/18723 | 3.93e-11 | 2.30e-09 | 171 |
GO:000726511 | Liver | Cirrhotic | Ras protein signal transduction | 119/4634 | 337/18723 | 8.16e-06 | 1.22e-04 | 119 |
GO:001660111 | Liver | Cirrhotic | Rac protein signal transduction | 19/4634 | 42/18723 | 3.00e-03 | 1.71e-02 | 19 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa051318 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa051008 | Colorectum | FAP | Bacterial invasion of epithelial cells | 33/1404 | 77/8465 | 4.33e-08 | 1.11e-06 | 6.77e-07 | 33 |
hsa051356 | Colorectum | FAP | Yersinia infection | 43/1404 | 137/8465 | 1.21e-05 | 1.62e-04 | 9.86e-05 | 43 |
hsa051328 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
hsa051319 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa051009 | Colorectum | FAP | Bacterial invasion of epithelial cells | 33/1404 | 77/8465 | 4.33e-08 | 1.11e-06 | 6.77e-07 | 33 |
hsa051357 | Colorectum | FAP | Yersinia infection | 43/1404 | 137/8465 | 1.21e-05 | 1.62e-04 | 9.86e-05 | 43 |
hsa051329 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0513226 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0510026 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELMO1 | SNV | Missense_Mutation | rs144700377 | c.1043G>A | p.Arg348His | p.R348H | Q92556 | protein_coding | tolerated(0.07) | probably_damaging(0.994) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ELMO1 | SNV | Missense_Mutation | c.2089N>A | p.Arg697Ser | p.R697S | Q92556 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ELMO1 | SNV | Missense_Mutation | rs776563605 | c.1061N>A | p.Arg354Gln | p.R354Q | Q92556 | protein_coding | tolerated(0.19) | benign(0.063) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ELMO1 | SNV | Missense_Mutation | c.1906N>A | p.Glu636Lys | p.E636K | Q92556 | protein_coding | tolerated(0.19) | benign(0.216) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
ELMO1 | SNV | Missense_Mutation | c.913N>A | p.Leu305Met | p.L305M | Q92556 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |
ELMO1 | SNV | Missense_Mutation | novel | c.1693N>T | p.Leu565Phe | p.L565F | Q92556 | protein_coding | tolerated(0.27) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ELMO1 | SNV | Missense_Mutation | c.1706N>T | p.Arg569Leu | p.R569L | Q92556 | protein_coding | deleterious(0) | possibly_damaging(0.716) | TCGA-BK-A139-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ELMO1 | SNV | Missense_Mutation | novel | c.1798C>T | p.Pro600Ser | p.P600S | Q92556 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELMO1 | SNV | Missense_Mutation | c.416N>A | p.Arg139Gln | p.R139Q | Q92556 | protein_coding | tolerated(0.24) | benign(0.182) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ELMO1 | SNV | Missense_Mutation | c.1292N>A | p.Gly431Asp | p.G431D | Q92556 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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