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Gene: EIF5 |
Gene summary for EIF5 |
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Gene information | Species | Human | Gene symbol | EIF5 | Gene ID | 1983 |
Gene name | eukaryotic translation initiation factor 5 | |
Gene Alias | EIF-5 | |
Cytomap | 14q32.32 | |
Gene Type | protein-coding | GO ID | GO:0001731 | UniProtAcc | A0A024R6Q1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1983 | EIF5 | GSM4909277 | Human | Breast | Precancer | 1.37e-05 | 5.06e-01 | 0.0177 |
1983 | EIF5 | GSM4909285 | Human | Breast | IDC | 3.38e-03 | -2.66e-01 | 0.21 |
1983 | EIF5 | GSM4909286 | Human | Breast | IDC | 1.62e-05 | -2.41e-01 | 0.1081 |
1983 | EIF5 | GSM4909287 | Human | Breast | IDC | 1.16e-03 | -4.08e-01 | 0.2057 |
1983 | EIF5 | GSM4909293 | Human | Breast | IDC | 1.17e-03 | -3.32e-01 | 0.1581 |
1983 | EIF5 | GSM4909294 | Human | Breast | IDC | 1.79e-04 | -3.68e-01 | 0.2022 |
1983 | EIF5 | GSM4909296 | Human | Breast | IDC | 7.00e-10 | -3.77e-01 | 0.1524 |
1983 | EIF5 | GSM4909297 | Human | Breast | IDC | 1.79e-15 | -3.42e-01 | 0.1517 |
1983 | EIF5 | GSM4909301 | Human | Breast | IDC | 1.59e-03 | -3.70e-01 | 0.1577 |
1983 | EIF5 | GSM4909302 | Human | Breast | IDC | 4.19e-11 | -5.55e-01 | 0.1545 |
1983 | EIF5 | GSM4909311 | Human | Breast | IDC | 6.26e-37 | -6.88e-01 | 0.1534 |
1983 | EIF5 | GSM4909312 | Human | Breast | IDC | 5.68e-15 | -4.79e-01 | 0.1552 |
1983 | EIF5 | GSM4909313 | Human | Breast | IDC | 1.26e-06 | -4.69e-01 | 0.0391 |
1983 | EIF5 | GSM4909319 | Human | Breast | IDC | 6.07e-43 | -6.40e-01 | 0.1563 |
1983 | EIF5 | GSM4909320 | Human | Breast | IDC | 3.52e-04 | -3.47e-01 | 0.1575 |
1983 | EIF5 | GSM4909321 | Human | Breast | IDC | 2.92e-11 | -2.65e-01 | 0.1559 |
1983 | EIF5 | brca1 | Human | Breast | Precancer | 1.15e-14 | 4.19e-01 | -0.0338 |
1983 | EIF5 | brca10 | Human | Breast | Precancer | 6.85e-05 | -4.55e-01 | -0.0029 |
1983 | EIF5 | NCCBC14 | Human | Breast | DCIS | 2.66e-07 | -1.32e-01 | 0.2021 |
1983 | EIF5 | NCCBC5 | Human | Breast | DCIS | 1.01e-11 | -3.84e-01 | 0.2046 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00971939 | Breast | Precancer | intrinsic apoptotic signaling pathway | 59/1080 | 288/18723 | 8.07e-18 | 3.60e-15 | 59 |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:20012429 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway | 41/1080 | 164/18723 | 6.48e-16 | 2.31e-13 | 41 |
GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
GO:00064138 | Breast | Precancer | translational initiation | 30/1080 | 118/18723 | 3.23e-12 | 5.58e-10 | 30 |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00457279 | Breast | Precancer | positive regulation of translation | 32/1080 | 136/18723 | 5.89e-12 | 9.27e-10 | 32 |
GO:00342509 | Breast | Precancer | positive regulation of cellular amide metabolic process | 33/1080 | 162/18723 | 1.72e-10 | 1.77e-08 | 33 |
GO:20012445 | Breast | Precancer | positive regulation of intrinsic apoptotic signaling pathway | 17/1080 | 58/18723 | 1.59e-08 | 1.12e-06 | 17 |
GO:00064466 | Breast | Precancer | regulation of translational initiation | 19/1080 | 79/18723 | 7.99e-08 | 4.60e-06 | 19 |
GO:20012356 | Breast | Precancer | positive regulation of apoptotic signaling pathway | 24/1080 | 126/18723 | 1.98e-07 | 1.01e-05 | 24 |
GO:19017989 | Breast | Precancer | positive regulation of signal transduction by p53 class mediator | 10/1080 | 25/18723 | 5.77e-07 | 2.49e-05 | 10 |
GO:19017969 | Breast | Precancer | regulation of signal transduction by p53 class mediator | 19/1080 | 93/18723 | 1.20e-06 | 4.60e-05 | 19 |
GO:00021838 | Breast | Precancer | cytoplasmic translational initiation | 11/1080 | 34/18723 | 1.87e-06 | 6.63e-05 | 11 |
GO:00723319 | Breast | Precancer | signal transduction by p53 class mediator | 26/1080 | 163/18723 | 2.23e-06 | 7.76e-05 | 26 |
GO:00723328 | Breast | Precancer | intrinsic apoptotic signaling pathway by p53 class mediator | 16/1080 | 76/18723 | 5.49e-06 | 1.63e-04 | 16 |
GO:00017328 | Breast | Precancer | formation of cytoplasmic translation initiation complex | 7/1080 | 16/18723 | 1.50e-05 | 3.71e-04 | 7 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF5 | SNV | Missense_Mutation | novel | c.1112N>G | p.Ile371Ser | p.I371S | P55010 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-BR-8060-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF5 | SNV | Missense_Mutation | rs771848345 | c.245N>T | p.Ala82Val | p.A82V | P55010 | protein_coding | tolerated(0.13) | benign(0.033) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF5 | SNV | Missense_Mutation | c.359N>T | p.Asn120Ile | p.N120I | P55010 | protein_coding | tolerated(0.06) | possibly_damaging(0.641) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
EIF5 | SNV | Missense_Mutation | novel | c.1232T>C | p.Val411Ala | p.V411A | P55010 | protein_coding | tolerated(0.76) | benign(0.007) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
EIF5 | SNV | Missense_Mutation | novel | c.182N>C | p.Leu61Pro | p.L61P | P55010 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EIF5 | insertion | Frame_Shift_Ins | novel | c.498_499insTTCATCAT | p.Asp167PhefsTer63 | p.D167Ffs*63 | P55010 | protein_coding | TCGA-EL-A3ZN-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EIF5 | insertion | Frame_Shift_Ins | novel | c.499_500insTATTTCAT | p.Asp167ValfsTer63 | p.D167Vfs*63 | P55010 | protein_coding | TCGA-EL-A3ZN-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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