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Gene: DYRK2 |
Gene summary for DYRK2 |
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Gene information | Species | Human | Gene symbol | DYRK2 | Gene ID | 8445 |
Gene name | dual specificity tyrosine phosphorylation regulated kinase 2 | |
Gene Alias | DYRK2 | |
Cytomap | 12q15 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q92630 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8445 | DYRK2 | HCC1_Meng | Human | Liver | HCC | 8.75e-48 | -7.58e-04 | 0.0246 |
8445 | DYRK2 | HCC2_Meng | Human | Liver | HCC | 1.32e-32 | 1.70e-01 | 0.0107 |
8445 | DYRK2 | cirrhotic2 | Human | Liver | Cirrhotic | 3.59e-04 | 4.83e-02 | 0.0201 |
8445 | DYRK2 | HCC1 | Human | Liver | HCC | 1.57e-06 | 3.61e+00 | 0.5336 |
8445 | DYRK2 | HCC2 | Human | Liver | HCC | 9.13e-10 | 3.16e+00 | 0.5341 |
8445 | DYRK2 | S014 | Human | Liver | HCC | 5.29e-19 | 6.72e-01 | 0.2254 |
8445 | DYRK2 | S015 | Human | Liver | HCC | 5.46e-14 | 6.16e-01 | 0.2375 |
8445 | DYRK2 | S016 | Human | Liver | HCC | 5.26e-26 | 8.34e-01 | 0.2243 |
8445 | DYRK2 | S027 | Human | Liver | HCC | 6.10e-09 | 6.89e-01 | 0.2446 |
8445 | DYRK2 | S028 | Human | Liver | HCC | 7.84e-15 | 5.49e-01 | 0.2503 |
8445 | DYRK2 | S029 | Human | Liver | HCC | 1.26e-10 | 3.78e-01 | 0.2581 |
8445 | DYRK2 | male-WTA | Human | Thyroid | PTC | 3.79e-16 | 1.72e-01 | 0.1037 |
8445 | DYRK2 | PTC01 | Human | Thyroid | PTC | 9.60e-03 | 5.99e-02 | 0.1899 |
8445 | DYRK2 | PTC04 | Human | Thyroid | PTC | 4.21e-05 | 8.86e-02 | 0.1927 |
8445 | DYRK2 | PTC05 | Human | Thyroid | PTC | 7.29e-06 | 2.83e-01 | 0.2065 |
8445 | DYRK2 | PTC06 | Human | Thyroid | PTC | 1.91e-12 | 3.95e-01 | 0.2057 |
8445 | DYRK2 | PTC07 | Human | Thyroid | PTC | 3.45e-17 | 1.54e-01 | 0.2044 |
8445 | DYRK2 | ATC09 | Human | Thyroid | ATC | 8.81e-03 | 1.17e-01 | 0.2871 |
8445 | DYRK2 | ATC12 | Human | Thyroid | ATC | 1.34e-10 | 1.78e-01 | 0.34 |
8445 | DYRK2 | ATC13 | Human | Thyroid | ATC | 6.11e-35 | 6.57e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000609112 | Liver | Cirrhotic | generation of precursor metabolites and energy | 238/4634 | 490/18723 | 6.85e-31 | 1.07e-27 | 238 |
GO:001598012 | Liver | Cirrhotic | energy derivation by oxidation of organic compounds | 154/4634 | 318/18723 | 3.11e-20 | 8.87e-18 | 154 |
GO:009719312 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway | 130/4634 | 288/18723 | 2.69e-14 | 2.45e-12 | 130 |
GO:000599612 | Liver | Cirrhotic | monosaccharide metabolic process | 104/4634 | 257/18723 | 1.74e-08 | 6.32e-07 | 104 |
GO:001931812 | Liver | Cirrhotic | hexose metabolic process | 97/4634 | 237/18723 | 2.67e-08 | 9.16e-07 | 97 |
GO:000600611 | Liver | Cirrhotic | glucose metabolic process | 82/4634 | 196/18723 | 1.01e-07 | 2.93e-06 | 82 |
GO:006201212 | Liver | Cirrhotic | regulation of small molecule metabolic process | 124/4634 | 334/18723 | 2.74e-07 | 6.79e-06 | 124 |
GO:004346712 | Liver | Cirrhotic | regulation of generation of precursor metabolites and energy | 58/4634 | 130/18723 | 5.81e-07 | 1.28e-05 | 58 |
GO:007233112 | Liver | Cirrhotic | signal transduction by p53 class mediator | 69/4634 | 163/18723 | 5.97e-07 | 1.30e-05 | 69 |
GO:00723326 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway by p53 class mediator | 38/4634 | 76/18723 | 1.75e-06 | 3.32e-05 | 38 |
GO:000610911 | Liver | Cirrhotic | regulation of carbohydrate metabolic process | 70/4634 | 178/18723 | 1.14e-05 | 1.62e-04 | 70 |
GO:00086306 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway in response to DNA damage | 42/4634 | 99/18723 | 8.44e-05 | 9.17e-04 | 42 |
GO:00427716 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 22/4634 | 43/18723 | 1.69e-04 | 1.59e-03 | 22 |
GO:004426211 | Liver | Cirrhotic | cellular carbohydrate metabolic process | 97/4634 | 283/18723 | 1.89e-04 | 1.76e-03 | 97 |
GO:00160511 | Liver | Cirrhotic | carbohydrate biosynthetic process | 73/4634 | 202/18723 | 1.91e-04 | 1.77e-03 | 73 |
GO:00109061 | Liver | Cirrhotic | regulation of glucose metabolic process | 47/4634 | 119/18723 | 2.61e-04 | 2.33e-03 | 47 |
GO:00106751 | Liver | Cirrhotic | regulation of cellular carbohydrate metabolic process | 54/4634 | 146/18723 | 6.53e-04 | 4.96e-03 | 54 |
GO:190179612 | Liver | Cirrhotic | regulation of signal transduction by p53 class mediator | 37/4634 | 93/18723 | 9.58e-04 | 6.78e-03 | 37 |
GO:00059771 | Liver | Cirrhotic | glycogen metabolic process | 30/4634 | 72/18723 | 1.18e-03 | 7.98e-03 | 30 |
GO:00060731 | Liver | Cirrhotic | cellular glucan metabolic process | 30/4634 | 73/18723 | 1.53e-03 | 9.99e-03 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DYRK2 | SNV | Missense_Mutation | rs201048832 | c.820C>T | p.Arg274Trp | p.R274W | Q92630 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DYRK2 | SNV | Missense_Mutation | c.571C>T | p.Arg191Cys | p.R191C | Q92630 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DYRK2 | SNV | Missense_Mutation | rs140246773 | c.1250N>T | p.Thr417Met | p.T417M | Q92630 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DYRK2 | SNV | Missense_Mutation | c.721G>A | p.Asp241Asn | p.D241N | Q92630 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
DYRK2 | SNV | Missense_Mutation | rs573469138 | c.1388G>A | p.Arg463His | p.R463H | Q92630 | protein_coding | deleterious(0.01) | possibly_damaging(0.66) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
DYRK2 | SNV | Missense_Mutation | c.235N>T | p.His79Tyr | p.H79Y | Q92630 | protein_coding | tolerated_low_confidence(1) | benign(0.027) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
DYRK2 | SNV | Missense_Mutation | rs752139842 | c.782N>A | p.Arg261Gln | p.R261Q | Q92630 | protein_coding | tolerated(0.14) | probably_damaging(0.998) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
DYRK2 | SNV | Missense_Mutation | rs575789813 | c.899N>T | p.Thr300Met | p.T300M | Q92630 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DYRK2 | SNV | Missense_Mutation | novel | c.85N>T | p.Ala29Ser | p.A29S | Q92630 | protein_coding | tolerated_low_confidence(0.67) | benign(0) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
DYRK2 | SNV | Missense_Mutation | rs748801595 | c.1447N>T | p.Arg483Trp | p.R483W | Q92630 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PMID28766366-Compound-Scheme21Left | |||
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | inhibitor | 249565847 | ||
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | inhibitor | 249565807 | ||
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PMID28766366-Compound-Scheme16DMAT | |||
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | HARMINE | HARMINE | 22998443 | |
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | LEUCETTAMINE B | LEUCETTAMINE B | 22998443 | |
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | HARMINE | HARMINE | ||
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PMID28766366-Compound-Scheme14BINDY | |||
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | inhibitor | 249565851 | ||
8445 | DYRK2 | SERINE THREONINE KINASE, TYROSINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PMID28766366-Compound-Scheme21Right |
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