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Gene: DTNA |
Gene summary for DTNA |
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Gene information | Species | Human | Gene symbol | DTNA | Gene ID | 1837 |
Gene name | dystrobrevin alpha | |
Gene Alias | D18S892E | |
Cytomap | 18q12.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y4J8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1837 | DTNA | NAFLD1 | Human | Liver | NAFLD | 2.33e-04 | 8.72e-01 | -0.04 |
1837 | DTNA | HCC1_Meng | Human | Liver | HCC | 2.20e-44 | 2.84e-02 | 0.0246 |
1837 | DTNA | cirrhotic3 | Human | Liver | Cirrhotic | 1.60e-04 | 3.81e-02 | 0.0215 |
1837 | DTNA | HCC2 | Human | Liver | HCC | 2.68e-12 | 3.53e+00 | 0.5341 |
1837 | DTNA | Pt13.b | Human | Liver | HCC | 3.17e-07 | 2.43e-02 | 0.0251 |
1837 | DTNA | Pt14.a | Human | Liver | HCC | 2.82e-06 | 3.47e-01 | 0.0169 |
1837 | DTNA | Pt14.b | Human | Liver | HCC | 1.76e-05 | 2.20e-01 | 0.018 |
1837 | DTNA | S016 | Human | Liver | HCC | 1.41e-02 | 2.04e-02 | 0.2243 |
1837 | DTNA | S027 | Human | Liver | HCC | 4.05e-05 | 7.82e-01 | 0.2446 |
1837 | DTNA | S028 | Human | Liver | HCC | 8.49e-27 | 1.11e+00 | 0.2503 |
1837 | DTNA | S029 | Human | Liver | HCC | 6.54e-19 | 9.42e-01 | 0.2581 |
1837 | DTNA | RNA-P17T-P17T-2 | Human | Lung | IAC | 5.30e-08 | 7.78e-01 | 0.3371 |
1837 | DTNA | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.13e-06 | 6.03e-01 | 0.343 |
1837 | DTNA | RNA-P17T-P17T-6 | Human | Lung | IAC | 2.66e-08 | 7.39e-01 | 0.3385 |
1837 | DTNA | RNA-P17T-P17T-8 | Human | Lung | IAC | 5.44e-06 | 7.25e-01 | 0.3329 |
1837 | DTNA | HTA12-15-2 | Human | Pancreas | PDAC | 4.79e-02 | 3.65e-01 | 0.2315 |
1837 | DTNA | HTA12-23-1 | Human | Pancreas | PDAC | 4.29e-05 | 7.29e-01 | 0.3405 |
1837 | DTNA | HTA12-25-1 | Human | Pancreas | PDAC | 1.23e-05 | 7.27e-01 | 0.313 |
1837 | DTNA | HTA12-26-1 | Human | Pancreas | PDAC | 8.94e-13 | 7.89e-01 | 0.3728 |
1837 | DTNA | HTA12-29-1 | Human | Pancreas | PDAC | 1.81e-31 | 8.33e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00030124 | Lung | IAC | muscle system process | 71/2061 | 452/18723 | 1.29e-03 | 1.45e-02 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DTNA | SNV | Missense_Mutation | novel | c.1003C>T | p.Pro335Ser | p.P335S | Q9Y4J8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
DTNA | SNV | Missense_Mutation | novel | c.1431N>C | p.Glu477Asp | p.E477D | Q9Y4J8 | protein_coding | tolerated(0.38) | probably_damaging(0.992) | TCGA-PG-A914-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DTNA | deletion | Frame_Shift_Del | novel | c.2124delT | p.Phe708LeufsTer46 | p.F708Lfs*46 | Q9Y4J8 | protein_coding | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | ||
DTNA | insertion | Frame_Shift_Ins | novel | c.604-1_604insA | p.Val204SerfsTer39 | p.V204Sfs*39 | Q9Y4J8 | protein_coding | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
DTNA | SNV | Missense_Mutation | rs374916548 | c.1094N>G | p.Glu365Gly | p.E365G | Q9Y4J8 | protein_coding | tolerated(0.12) | benign(0.068) | TCGA-BW-A5NP-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | sorafenib | PD |
DTNA | SNV | Missense_Mutation | c.1460N>T | p.Glu487Val | p.E487V | Q9Y4J8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
DTNA | SNV | Missense_Mutation | c.1733N>T | p.Glu578Val | p.E578V | Q9Y4J8 | protein_coding | deleterious(0.01) | possibly_damaging(0.583) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DTNA | SNV | Missense_Mutation | novel | c.998N>C | p.Ile333Thr | p.I333T | Q9Y4J8 | protein_coding | tolerated(0.05) | probably_damaging(0.987) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DTNA | SNV | Missense_Mutation | c.1867A>T | p.Ser623Cys | p.S623C | Q9Y4J8 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.774) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DTNA | SNV | Missense_Mutation | c.520N>T | p.Val174Phe | p.V174F | Q9Y4J8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-35-5375-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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