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Gene: DOCK11 |
Gene summary for DOCK11 |
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Gene information | Species | Human | Gene symbol | DOCK11 | Gene ID | 139818 |
Gene name | dedicator of cytokinesis 11 | |
Gene Alias | ACG | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q5JSL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
139818 | DOCK11 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.12e-09 | 3.05e-01 | -0.1464 |
139818 | DOCK11 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.97e-02 | 9.02e-02 | -0.1001 |
139818 | DOCK11 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.08e-03 | 1.82e-01 | -0.059 |
139818 | DOCK11 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.43e-09 | 5.03e-01 | 0.281 |
139818 | DOCK11 | A001-C-119 | Human | Colorectum | FAP | 1.92e-02 | 4.08e-01 | -0.1557 |
139818 | DOCK11 | A002-C-021 | Human | Colorectum | FAP | 2.06e-05 | 3.64e-01 | 0.1171 |
139818 | DOCK11 | male-WTA | Human | Thyroid | PTC | 5.45e-21 | 1.74e-01 | 0.1037 |
139818 | DOCK11 | PTC01 | Human | Thyroid | PTC | 4.13e-12 | 2.04e-01 | 0.1899 |
139818 | DOCK11 | PTC04 | Human | Thyroid | PTC | 6.06e-12 | 2.53e-01 | 0.1927 |
139818 | DOCK11 | PTC05 | Human | Thyroid | PTC | 6.45e-18 | 5.92e-01 | 0.2065 |
139818 | DOCK11 | PTC06 | Human | Thyroid | PTC | 4.28e-41 | 8.09e-01 | 0.2057 |
139818 | DOCK11 | PTC07 | Human | Thyroid | PTC | 8.30e-18 | 3.14e-01 | 0.2044 |
139818 | DOCK11 | ATC12 | Human | Thyroid | ATC | 1.25e-15 | 3.16e-01 | 0.34 |
139818 | DOCK11 | ATC13 | Human | Thyroid | ATC | 1.27e-28 | 5.07e-01 | 0.34 |
139818 | DOCK11 | ATC2 | Human | Thyroid | ATC | 2.37e-04 | 3.12e-01 | 0.34 |
139818 | DOCK11 | ATC4 | Human | Thyroid | ATC | 1.22e-19 | 4.18e-01 | 0.34 |
139818 | DOCK11 | ATC5 | Human | Thyroid | ATC | 2.97e-27 | 5.54e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0001782 | Colorectum | AD | B cell homeostasis | 13/3918 | 31/18723 | 6.53e-03 | 4.06e-02 | 13 |
GO:0120034 | Colorectum | AD | positive regulation of plasma membrane bounded cell projection assembly | 33/3918 | 105/18723 | 7.49e-03 | 4.55e-02 | 33 |
GO:0120032 | Colorectum | AD | regulation of plasma membrane bounded cell projection assembly | 53/3918 | 186/18723 | 8.51e-03 | 4.97e-02 | 53 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00488722 | Colorectum | MSS | homeostasis of number of cells | 82/3467 | 272/18723 | 2.02e-06 | 6.28e-05 | 82 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00435471 | Colorectum | MSS | positive regulation of GTPase activity | 68/3467 | 255/18723 | 7.97e-04 | 8.38e-03 | 68 |
GO:01200322 | Colorectum | MSS | regulation of plasma membrane bounded cell projection assembly | 51/3467 | 186/18723 | 1.78e-03 | 1.58e-02 | 51 |
GO:00604911 | Colorectum | MSS | regulation of cell projection assembly | 51/3467 | 188/18723 | 2.28e-03 | 1.87e-02 | 51 |
GO:00017821 | Colorectum | MSS | B cell homeostasis | 12/3467 | 31/18723 | 6.80e-03 | 4.39e-02 | 12 |
GO:01200341 | Colorectum | MSS | positive regulation of plasma membrane bounded cell projection assembly | 30/3467 | 105/18723 | 7.74e-03 | 4.84e-02 | 30 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00313463 | Colorectum | FAP | positive regulation of cell projection organization | 82/2622 | 353/18723 | 1.78e-06 | 7.35e-05 | 82 |
GO:00435472 | Colorectum | FAP | positive regulation of GTPase activity | 61/2622 | 255/18723 | 1.39e-05 | 3.73e-04 | 61 |
GO:00488724 | Colorectum | FAP | homeostasis of number of cells | 60/2622 | 272/18723 | 1.91e-04 | 2.79e-03 | 60 |
GO:1903131 | Colorectum | FAP | mononuclear cell differentiation | 79/2622 | 426/18723 | 5.00e-03 | 3.33e-02 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOCK11 | SNV | Missense_Mutation | rs755708340 | c.1555N>T | p.Arg519Cys | p.R519C | Q5JSL3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
DOCK11 | SNV | Missense_Mutation | novel | c.1957N>T | p.Asp653Tyr | p.D653Y | Q5JSL3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DOCK11 | SNV | Missense_Mutation | c.3647N>T | p.Ser1216Ile | p.S1216I | Q5JSL3 | protein_coding | tolerated(0.24) | benign(0) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOCK11 | SNV | Missense_Mutation | novel | c.639T>G | p.Asn213Lys | p.N213K | Q5JSL3 | protein_coding | tolerated(1) | possibly_damaging(0.469) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DOCK11 | SNV | Missense_Mutation | rs747026752 | c.3587C>A | p.Ser1196Tyr | p.S1196Y | Q5JSL3 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DOCK11 | SNV | Missense_Mutation | novel | c.979A>C | p.Lys327Gln | p.K327Q | Q5JSL3 | protein_coding | tolerated(0.07) | benign(0.052) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DOCK11 | SNV | Missense_Mutation | novel | c.2174A>T | p.Lys725Ile | p.K725I | Q5JSL3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DOCK11 | SNV | Missense_Mutation | c.919N>A | p.Leu307Met | p.L307M | Q5JSL3 | protein_coding | deleterious(0.01) | possibly_damaging(0.737) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DOCK11 | SNV | Missense_Mutation | c.2827N>T | p.Ala943Ser | p.A943S | Q5JSL3 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DOCK11 | SNV | Missense_Mutation | c.2686N>A | p.Leu896Ile | p.L896I | Q5JSL3 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-DM-A1D9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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