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Gene: DOCK10 |
Gene summary for DOCK10 |
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Gene information | Species | Human | Gene symbol | DOCK10 | Gene ID | 55619 |
Gene name | dedicator of cytokinesis 10 | |
Gene Alias | DRIP2 | |
Cytomap | 2q36.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q96BY6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55619 | DOCK10 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 1.48e-05 | 8.60e-01 | -0.0186 |
55619 | DOCK10 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 1.19e-03 | 7.32e-01 | -0.0296 |
55619 | DOCK10 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 1.14e-02 | 6.05e-01 | -0.0263 |
55619 | DOCK10 | EOLP-1 | Human | Oral cavity | EOLP | 8.65e-21 | 6.92e-01 | -0.0202 |
55619 | DOCK10 | EOLP-2 | Human | Oral cavity | EOLP | 2.07e-20 | 6.17e-01 | -0.0203 |
55619 | DOCK10 | NEOLP-2 | Human | Oral cavity | NEOLP | 9.75e-08 | 3.56e-01 | -0.0196 |
55619 | DOCK10 | NEOLP-3 | Human | Oral cavity | NEOLP | 3.87e-06 | 3.86e-01 | -0.0191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004308721 | Lung | MIAC | regulation of GTPase activity | 41/967 | 348/18723 | 7.39e-07 | 1.08e-04 | 41 |
GO:004354721 | Lung | MIAC | positive regulation of GTPase activity | 31/967 | 255/18723 | 8.63e-06 | 7.38e-04 | 31 |
GO:004887223 | Lung | MIAC | homeostasis of number of cells | 27/967 | 272/18723 | 9.04e-04 | 1.92e-02 | 27 |
GO:001635831 | Lung | MIAC | dendrite development | 23/967 | 243/18723 | 3.82e-03 | 4.69e-02 | 23 |
GO:004887226 | Oral cavity | EOLP | homeostasis of number of cells | 68/2218 | 272/18723 | 1.20e-09 | 8.27e-08 | 68 |
GO:190313114 | Oral cavity | EOLP | mononuclear cell differentiation | 88/2218 | 426/18723 | 1.07e-07 | 3.61e-06 | 88 |
GO:001635815 | Oral cavity | EOLP | dendrite development | 55/2218 | 243/18723 | 1.43e-06 | 3.42e-05 | 55 |
GO:003009812 | Oral cavity | EOLP | lymphocyte differentiation | 76/2218 | 374/18723 | 1.50e-06 | 3.55e-05 | 76 |
GO:006099614 | Oral cavity | EOLP | dendritic spine development | 27/2218 | 99/18723 | 2.21e-05 | 3.37e-04 | 27 |
GO:00022633 | Oral cavity | EOLP | cell activation involved in immune response | 56/2218 | 279/18723 | 4.91e-05 | 6.47e-04 | 56 |
GO:00023662 | Oral cavity | EOLP | leukocyte activation involved in immune response | 55/2218 | 275/18723 | 6.32e-05 | 7.90e-04 | 55 |
GO:004308714 | Oral cavity | EOLP | regulation of GTPase activity | 66/2218 | 348/18723 | 6.92e-05 | 8.55e-04 | 66 |
GO:00022852 | Oral cavity | EOLP | lymphocyte activation involved in immune response | 42/2218 | 194/18723 | 7.17e-05 | 8.82e-04 | 42 |
GO:00488137 | Oral cavity | EOLP | dendrite morphogenesis | 34/2218 | 146/18723 | 7.56e-05 | 9.19e-04 | 34 |
GO:00421132 | Oral cavity | EOLP | B cell activation | 61/2218 | 334/18723 | 3.68e-04 | 3.35e-03 | 61 |
GO:01060279 | Oral cavity | EOLP | neuron projection organization | 23/2218 | 93/18723 | 4.20e-04 | 3.72e-03 | 23 |
GO:00017761 | Oral cavity | EOLP | leukocyte homeostasis | 21/2218 | 87/18723 | 1.03e-03 | 7.63e-03 | 21 |
GO:00435479 | Oral cavity | EOLP | positive regulation of GTPase activity | 47/2218 | 255/18723 | 1.34e-03 | 9.33e-03 | 47 |
GO:00970618 | Oral cavity | EOLP | dendritic spine organization | 20/2218 | 84/18723 | 1.60e-03 | 1.07e-02 | 20 |
GO:004887233 | Oral cavity | NEOLP | homeostasis of number of cells | 65/2005 | 272/18723 | 3.20e-10 | 2.93e-08 | 65 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOCK10 | SNV | Missense_Mutation | rs770099671 | c.416N>A | p.Arg139Gln | p.R139Q | Q96BY6 | protein_coding | tolerated(0.39) | benign(0.011) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DOCK10 | SNV | Missense_Mutation | c.1402N>A | p.Asp468Asn | p.D468N | Q96BY6 | protein_coding | tolerated(0.24) | benign(0.085) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DOCK10 | SNV | Missense_Mutation | rs776429569 | c.556N>A | p.Gly186Ser | p.G186S | Q96BY6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3725-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DOCK10 | SNV | Missense_Mutation | c.5661N>G | p.Phe1887Leu | p.F1887L | Q96BY6 | protein_coding | deleterious(0) | benign(0.113) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DOCK10 | SNV | Missense_Mutation | rs374472028 | c.4046N>T | p.Ser1349Leu | p.S1349L | Q96BY6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DOCK10 | SNV | Missense_Mutation | novel | c.214N>A | p.Leu72Ile | p.L72I | Q96BY6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DOCK10 | SNV | Missense_Mutation | novel | c.5597N>G | p.Val1866Gly | p.V1866G | Q96BY6 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DOCK10 | SNV | Missense_Mutation | novel | c.3936N>T | p.Lys1312Asn | p.K1312N | Q96BY6 | protein_coding | tolerated(0.21) | probably_damaging(0.994) | TCGA-EF-5831-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DOCK10 | SNV | Missense_Mutation | novel | c.2207N>T | p.His736Leu | p.H736L | Q96BY6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EF-5831-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DOCK10 | SNV | Missense_Mutation | rs374472028 | c.4046C>T | p.Ser1349Leu | p.S1349L | Q96BY6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55619 | DOCK10 | NA | INTERLEUKIN-4 | 18499258 |
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