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Gene: DMXL2 |
Gene summary for DMXL2 |
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Gene information | Species | Human | Gene symbol | DMXL2 | Gene ID | 23312 |
Gene name | Dmx like 2 | |
Gene Alias | DEE81 | |
Cytomap | 15q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | Q8TDJ6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23312 | DMXL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.96e-16 | -5.42e-01 | 0.0155 |
23312 | DMXL2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.71e-02 | -4.35e-01 | -0.1207 |
23312 | DMXL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.40e-11 | -4.42e-01 | -0.1464 |
23312 | DMXL2 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.88e-13 | -4.57e-01 | -0.1001 |
23312 | DMXL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.26e-04 | -3.98e-01 | -0.059 |
23312 | DMXL2 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.90e-02 | -4.77e-01 | -0.0842 |
23312 | DMXL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.81e-12 | -5.17e-01 | 0.096 |
23312 | DMXL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.40e-03 | -5.56e-01 | 0.0528 |
23312 | DMXL2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.10e-11 | -5.70e-01 | 0.0338 |
23312 | DMXL2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.30e-22 | -5.28e-01 | 0.0674 |
23312 | DMXL2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.27e-05 | -5.13e-01 | 0.0588 |
23312 | DMXL2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.88e-08 | -3.73e-01 | 0.294 |
23312 | DMXL2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.49e-16 | -4.79e-01 | 0.3859 |
23312 | DMXL2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.04e-06 | -5.64e-01 | 0.2585 |
23312 | DMXL2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.10e-14 | -4.84e-01 | 0.3005 |
23312 | DMXL2 | F007 | Human | Colorectum | FAP | 2.53e-02 | -3.49e-01 | 0.1176 |
23312 | DMXL2 | A002-C-010 | Human | Colorectum | FAP | 4.45e-13 | -3.77e-01 | 0.242 |
23312 | DMXL2 | A015-C-203 | Human | Colorectum | FAP | 9.02e-20 | -2.97e-01 | -0.1294 |
23312 | DMXL2 | A015-C-204 | Human | Colorectum | FAP | 2.22e-03 | -2.29e-01 | -0.0228 |
23312 | DMXL2 | A002-C-201 | Human | Colorectum | FAP | 2.03e-08 | -2.53e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:0030641 | Colorectum | AD | regulation of cellular pH | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:0051453 | Colorectum | AD | regulation of intracellular pH | 26/3918 | 75/18723 | 4.04e-03 | 2.82e-02 | 26 |
GO:0006885 | Colorectum | AD | regulation of pH | 30/3918 | 91/18723 | 4.95e-03 | 3.32e-02 | 30 |
GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
GO:00300041 | Colorectum | SER | cellular monovalent inorganic cation homeostasis | 31/2897 | 103/18723 | 1.31e-04 | 2.66e-03 | 31 |
GO:00306411 | Colorectum | SER | regulation of cellular pH | 24/2897 | 81/18723 | 9.20e-04 | 1.11e-02 | 24 |
GO:00550671 | Colorectum | SER | monovalent inorganic cation homeostasis | 37/2897 | 151/18723 | 2.48e-03 | 2.33e-02 | 37 |
GO:00514531 | Colorectum | SER | regulation of intracellular pH | 21/2897 | 75/18723 | 3.97e-03 | 3.26e-02 | 21 |
GO:00068851 | Colorectum | SER | regulation of pH | 24/2897 | 91/18723 | 5.03e-03 | 3.88e-02 | 24 |
GO:00300042 | Colorectum | MSS | cellular monovalent inorganic cation homeostasis | 31/3467 | 103/18723 | 2.94e-03 | 2.27e-02 | 31 |
GO:00306412 | Colorectum | MSS | regulation of cellular pH | 25/3467 | 81/18723 | 4.97e-03 | 3.46e-02 | 25 |
GO:00300043 | Colorectum | FAP | cellular monovalent inorganic cation homeostasis | 28/2622 | 103/18723 | 3.23e-04 | 4.15e-03 | 28 |
GO:00514532 | Colorectum | FAP | regulation of intracellular pH | 22/2622 | 75/18723 | 4.38e-04 | 5.21e-03 | 22 |
GO:00306413 | Colorectum | FAP | regulation of cellular pH | 22/2622 | 81/18723 | 1.37e-03 | 1.24e-02 | 22 |
GO:00550672 | Colorectum | FAP | monovalent inorganic cation homeostasis | 35/2622 | 151/18723 | 1.58e-03 | 1.40e-02 | 35 |
GO:00068852 | Colorectum | FAP | regulation of pH | 23/2622 | 91/18723 | 3.00e-03 | 2.27e-02 | 23 |
GO:00514533 | Colorectum | CRC | regulation of intracellular pH | 17/2078 | 75/18723 | 3.04e-03 | 2.71e-02 | 17 |
GO:00300044 | Colorectum | CRC | cellular monovalent inorganic cation homeostasis | 21/2078 | 103/18723 | 4.15e-03 | 3.40e-02 | 21 |
GO:00306414 | Colorectum | CRC | regulation of cellular pH | 17/2078 | 81/18723 | 6.93e-03 | 4.85e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMXL2 | SNV | Missense_Mutation | c.4114N>T | p.Val1372Leu | p.V1372L | Q8TDJ6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3662-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PR | |
DMXL2 | SNV | Missense_Mutation | novel | c.7484C>A | p.Thr2495Lys | p.T2495K | Q8TDJ6 | protein_coding | tolerated(0.17) | benign(0.049) | TCGA-AA-3688-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DMXL2 | SNV | Missense_Mutation | c.2731C>T | p.His911Tyr | p.H911Y | Q8TDJ6 | protein_coding | deleterious(0.01) | benign(0.122) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
DMXL2 | SNV | Missense_Mutation | c.3898N>G | p.Thr1300Ala | p.T1300A | Q8TDJ6 | protein_coding | tolerated(0.87) | benign(0) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DMXL2 | SNV | Missense_Mutation | c.718N>C | p.Trp240Arg | p.W240R | Q8TDJ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DMXL2 | SNV | Missense_Mutation | c.5437N>A | p.Asp1813Asn | p.D1813N | Q8TDJ6 | protein_coding | tolerated(0.37) | benign(0.007) | TCGA-AA-3842-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |
DMXL2 | SNV | Missense_Mutation | c.1517C>A | p.Pro506His | p.P506H | Q8TDJ6 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DMXL2 | SNV | Missense_Mutation | c.3188G>A | p.Ser1063Asn | p.S1063N | Q8TDJ6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3869-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
DMXL2 | SNV | Missense_Mutation | c.8179C>G | p.Gln2727Glu | p.Q2727E | Q8TDJ6 | protein_coding | tolerated(0.14) | benign(0.2) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
DMXL2 | SNV | Missense_Mutation | c.5534G>A | p.Arg1845Gln | p.R1845Q | Q8TDJ6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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