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Gene: DMTF1 |
Gene summary for DMTF1 |
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Gene information | Species | Human | Gene symbol | DMTF1 | Gene ID | 9988 |
Gene name | cyclin D binding myb like transcription factor 1 | |
Gene Alias | DMP1 | |
Cytomap | 7q21.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KMJ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9988 | DMTF1 | LZE4T | Human | Esophagus | ESCC | 4.27e-08 | 1.47e-01 | 0.0811 |
9988 | DMTF1 | LZE5T | Human | Esophagus | ESCC | 8.37e-04 | 2.90e-01 | 0.0514 |
9988 | DMTF1 | LZE7T | Human | Esophagus | ESCC | 5.89e-11 | 4.16e-01 | 0.0667 |
9988 | DMTF1 | LZE20T | Human | Esophagus | ESCC | 4.35e-07 | 1.73e-01 | 0.0662 |
9988 | DMTF1 | LZE24T | Human | Esophagus | ESCC | 3.68e-14 | 2.00e-01 | 0.0596 |
9988 | DMTF1 | P1T-E | Human | Esophagus | ESCC | 9.63e-06 | 2.67e-01 | 0.0875 |
9988 | DMTF1 | P2T-E | Human | Esophagus | ESCC | 9.31e-18 | 2.70e-01 | 0.1177 |
9988 | DMTF1 | P4T-E | Human | Esophagus | ESCC | 1.47e-06 | 2.46e-01 | 0.1323 |
9988 | DMTF1 | P5T-E | Human | Esophagus | ESCC | 3.89e-11 | 1.39e-01 | 0.1327 |
9988 | DMTF1 | P8T-E | Human | Esophagus | ESCC | 7.39e-15 | 2.21e-01 | 0.0889 |
9988 | DMTF1 | P9T-E | Human | Esophagus | ESCC | 1.65e-14 | 2.14e-01 | 0.1131 |
9988 | DMTF1 | P10T-E | Human | Esophagus | ESCC | 1.26e-21 | 4.09e-01 | 0.116 |
9988 | DMTF1 | P11T-E | Human | Esophagus | ESCC | 2.99e-15 | 2.48e-01 | 0.1426 |
9988 | DMTF1 | P12T-E | Human | Esophagus | ESCC | 7.40e-24 | 4.11e-01 | 0.1122 |
9988 | DMTF1 | P15T-E | Human | Esophagus | ESCC | 1.24e-17 | 3.88e-01 | 0.1149 |
9988 | DMTF1 | P16T-E | Human | Esophagus | ESCC | 1.14e-42 | 7.36e-01 | 0.1153 |
9988 | DMTF1 | P17T-E | Human | Esophagus | ESCC | 6.28e-05 | 1.61e-01 | 0.1278 |
9988 | DMTF1 | P20T-E | Human | Esophagus | ESCC | 8.74e-18 | 4.33e-01 | 0.1124 |
9988 | DMTF1 | P21T-E | Human | Esophagus | ESCC | 3.09e-17 | 2.71e-01 | 0.1617 |
9988 | DMTF1 | P22T-E | Human | Esophagus | ESCC | 7.25e-20 | 2.07e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMTF1 | SNV | Missense_Mutation | novel | c.19N>T | p.Asp7Tyr | p.D7Y | Q9Y222 | protein_coding | deleterious_low_confidence(0.01) | benign(0.235) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DMTF1 | SNV | Missense_Mutation | novel | c.1052T>A | p.Ile351Lys | p.I351K | Q9Y222 | protein_coding | deleterious(0) | benign(0.284) | TCGA-58-8390-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DMTF1 | SNV | Missense_Mutation | novel | c.433A>T | p.Thr145Ser | p.T145S | Q9Y222 | protein_coding | tolerated(0.35) | benign(0.029) | TCGA-63-A5MG-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DMTF1 | deletion | Frame_Shift_Del | c.2133delT | p.Ile712Ter | p.I712* | Q9Y222 | protein_coding | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
DMTF1 | SNV | Missense_Mutation | novel | c.2107N>A | p.His703Asn | p.H703N | Q9Y222 | protein_coding | tolerated_low_confidence(0.26) | benign(0.003) | TCGA-CQ-7063-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DMTF1 | SNV | Missense_Mutation | novel | c.1361N>T | p.Ser454Phe | p.S454F | Q9Y222 | protein_coding | tolerated(0.69) | benign(0.085) | TCGA-CR-7368-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | Complete Response | |
DMTF1 | SNV | Missense_Mutation | novel | c.1105N>A | p.Glu369Lys | p.E369K | Q9Y222 | protein_coding | tolerated(0.4) | benign(0.007) | TCGA-CX-7085-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DMTF1 | SNV | Missense_Mutation | rs769167320 | c.470C>T | p.Ser157Phe | p.S157F | Q9Y222 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DMTF1 | SNV | Missense_Mutation | novel | c.8C>G | p.Thr3Arg | p.T3R | Q9Y222 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.879) | TCGA-QK-A6VC-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DMTF1 | insertion | Nonsense_Mutation | novel | c.991_992insAAAA | p.Trp331Ter | p.W331* | Q9Y222 | protein_coding | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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