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Gene: DISP2 |
Gene summary for DISP2 |
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Gene information | Species | Human | Gene symbol | DISP2 | Gene ID | 85455 |
Gene name | dispatched RND transporter family member 2 | |
Gene Alias | C15orf36 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A7MBM2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85455 | DISP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.37e-11 | 4.01e-01 | -0.1808 |
85455 | DISP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.70e-02 | 1.44e-01 | -0.1088 |
85455 | DISP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.76e-02 | 1.01e-01 | -0.1954 |
85455 | DISP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.40e-05 | 3.50e-01 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DISP2 | SNV | Missense_Mutation | novel | c.3926N>C | p.Val1309Ala | p.V1309A | A7MBM2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.647) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | rs765406694 | c.3563N>A | p.Arg1188Gln | p.R1188Q | A7MBM2 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | rs748707092 | c.4108N>A | p.Gly1370Arg | p.G1370R | A7MBM2 | protein_coding | deleterious(0.01) | possibly_damaging(0.715) | TCGA-AX-A3G6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | c.1295N>T | p.Ser432Phe | p.S432F | A7MBM2 | protein_coding | deleterious(0.01) | probably_damaging(0.952) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
DISP2 | SNV | Missense_Mutation | c.3284N>C | p.Val1095Ala | p.V1095A | A7MBM2 | protein_coding | deleterious(0) | possibly_damaging(0.775) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
DISP2 | SNV | Missense_Mutation | c.3860N>T | p.Ser1287Ile | p.S1287I | A7MBM2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DISP2 | SNV | Missense_Mutation | novel | c.214N>T | p.Pro72Ser | p.P72S | A7MBM2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.088) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | rs374870102 | c.2734N>T | p.Arg912Trp | p.R912W | A7MBM2 | protein_coding | tolerated(0.18) | benign(0.01) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | rs200105296 | c.3515N>A | p.Arg1172Gln | p.R1172Q | A7MBM2 | protein_coding | tolerated(0.51) | possibly_damaging(0.883) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | c.849G>T | p.Glu283Asp | p.E283D | A7MBM2 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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