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Gene: DIS3L2 |
Gene summary for DIS3L2 |
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Gene information | Species | Human | Gene symbol | DIS3L2 | Gene ID | 129563 |
Gene name | DIS3 like 3'-5' exoribonuclease 2 | |
Gene Alias | FAM6A | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q8IYB7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
129563 | DIS3L2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.60e-11 | -5.04e-01 | 0.0155 |
129563 | DIS3L2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.80e-03 | -4.44e-01 | -0.1808 |
129563 | DIS3L2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.37e-02 | -4.68e-01 | -0.0179 |
129563 | DIS3L2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.05e-02 | -3.70e-01 | 0.096 |
129563 | DIS3L2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.30e-04 | -3.67e-01 | 0.0674 |
129563 | DIS3L2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.68e-07 | -4.12e-01 | 0.294 |
129563 | DIS3L2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.06e-03 | -3.22e-01 | 0.3005 |
129563 | DIS3L2 | A001-C-207 | Human | Colorectum | FAP | 3.29e-03 | -1.83e-01 | 0.1278 |
129563 | DIS3L2 | A015-C-203 | Human | Colorectum | FAP | 2.25e-33 | -4.15e-01 | -0.1294 |
129563 | DIS3L2 | A015-C-204 | Human | Colorectum | FAP | 4.83e-05 | -2.33e-01 | -0.0228 |
129563 | DIS3L2 | A014-C-040 | Human | Colorectum | FAP | 2.06e-06 | -5.53e-01 | -0.1184 |
129563 | DIS3L2 | A002-C-201 | Human | Colorectum | FAP | 1.64e-16 | -3.95e-01 | 0.0324 |
129563 | DIS3L2 | A002-C-203 | Human | Colorectum | FAP | 1.18e-04 | 5.29e-04 | 0.2786 |
129563 | DIS3L2 | A001-C-119 | Human | Colorectum | FAP | 3.62e-06 | -3.46e-01 | -0.1557 |
129563 | DIS3L2 | A001-C-108 | Human | Colorectum | FAP | 1.62e-18 | -3.22e-01 | -0.0272 |
129563 | DIS3L2 | A002-C-205 | Human | Colorectum | FAP | 1.55e-23 | -4.34e-01 | -0.1236 |
129563 | DIS3L2 | A001-C-104 | Human | Colorectum | FAP | 1.08e-04 | -6.86e-02 | 0.0184 |
129563 | DIS3L2 | A015-C-006 | Human | Colorectum | FAP | 3.38e-19 | -4.31e-01 | -0.0994 |
129563 | DIS3L2 | A015-C-106 | Human | Colorectum | FAP | 1.15e-09 | -1.74e-01 | -0.0511 |
129563 | DIS3L2 | A002-C-114 | Human | Colorectum | FAP | 2.46e-19 | -3.18e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0043488 | Colorectum | AD | regulation of mRNA stability | 59/3918 | 158/18723 | 1.50e-06 | 4.66e-05 | 59 |
GO:1903313 | Colorectum | AD | positive regulation of mRNA metabolic process | 44/3918 | 118/18723 | 3.20e-05 | 5.87e-04 | 44 |
GO:0000956 | Colorectum | AD | nuclear-transcribed mRNA catabolic process | 40/3918 | 112/18723 | 2.11e-04 | 2.79e-03 | 40 |
GO:0061014 | Colorectum | AD | positive regulation of mRNA catabolic process | 32/3918 | 87/18723 | 4.81e-04 | 5.27e-03 | 32 |
GO:0061157 | Colorectum | AD | mRNA destabilization | 30/3918 | 84/18723 | 1.24e-03 | 1.09e-02 | 30 |
GO:0050779 | Colorectum | AD | RNA destabilization | 30/3918 | 88/18723 | 2.83e-03 | 2.12e-02 | 30 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DIS3L2 | SNV | Missense_Mutation | c.911G>A | p.Arg304His | p.R304H | Q8IYB7 | protein_coding | deleterious(0.04) | benign(0.009) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
DIS3L2 | SNV | Missense_Mutation | novel | c.2404C>A | p.Leu802Met | p.L802M | Q8IYB7 | protein_coding | tolerated(0.16) | possibly_damaging(0.679) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
DIS3L2 | insertion | In_Frame_Ins | novel | c.937_938insGGTTAT | p.Asn313delinsArgLeuTyr | p.N313delinsRLY | Q8IYB7 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DIS3L2 | insertion | Frame_Shift_Ins | novel | c.135_136insA | p.Ser48GlufsTer4 | p.S48Efs*4 | Q8IYB7 | protein_coding | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
DIS3L2 | SNV | Missense_Mutation | c.937N>G | p.Asn313Asp | p.N313D | Q8IYB7 | protein_coding | tolerated(0.13) | benign(0.085) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
DIS3L2 | SNV | Missense_Mutation | rs772470899 | c.796G>T | p.Ala266Ser | p.A266S | Q8IYB7 | protein_coding | deleterious(0.01) | benign(0.407) | TCGA-ZP-A9CY-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DIS3L2 | SNV | Missense_Mutation | rs776359062 | c.1378N>A | p.Asp460Asn | p.D460N | Q8IYB7 | protein_coding | deleterious(0.03) | probably_damaging(0.992) | TCGA-ZS-A9CD-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DIS3L2 | SNV | Missense_Mutation | novel | c.1187G>T | p.Cys396Phe | p.C396F | Q8IYB7 | protein_coding | deleterious(0) | possibly_damaging(0.752) | TCGA-05-4249-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DIS3L2 | SNV | Missense_Mutation | novel | c.1300G>T | p.Val434Phe | p.V434F | Q8IYB7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-05-4405-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DIS3L2 | SNV | Missense_Mutation | c.2010N>T | p.Gln670His | p.Q670H | Q8IYB7 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-49-4505-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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