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Gene: DICER1 |
Gene summary for DICER1 |
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Gene information | Species | Human | Gene symbol | DICER1 | Gene ID | 23405 |
Gene name | dicer 1, ribonuclease III | |
Gene Alias | DCR1 | |
Cytomap | 14q32.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9UPY3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23405 | DICER1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.47e-19 | -7.45e-01 | 0.0155 |
23405 | DICER1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.05e-11 | -7.45e-01 | -0.1808 |
23405 | DICER1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.71e-03 | -8.31e-01 | 0.0216 |
23405 | DICER1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.86e-08 | -7.24e-01 | -0.0811 |
23405 | DICER1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.44e-08 | -7.41e-01 | -0.1207 |
23405 | DICER1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.81e-02 | -5.03e-01 | -0.1526 |
23405 | DICER1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.28e-16 | -5.37e-01 | -0.1464 |
23405 | DICER1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.71e-17 | -6.20e-01 | -0.1001 |
23405 | DICER1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.91e-02 | -4.51e-01 | -0.059 |
23405 | DICER1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.56e-03 | -7.35e-01 | -0.1706 |
23405 | DICER1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.72e-04 | -7.75e-01 | -0.2061 |
23405 | DICER1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.33e-02 | -5.94e-01 | -0.0179 |
23405 | DICER1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.75e-15 | -7.21e-01 | 0.096 |
23405 | DICER1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.33e-04 | -7.15e-01 | 0.0528 |
23405 | DICER1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.56e-09 | -7.15e-01 | 0.0338 |
23405 | DICER1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.73e-19 | -5.96e-01 | 0.0674 |
23405 | DICER1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.56e-02 | -6.07e-01 | 0.0112 |
23405 | DICER1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.66e-04 | -5.99e-01 | 0.0588 |
23405 | DICER1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.63e-15 | -5.29e-01 | 0.294 |
23405 | DICER1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.67e-36 | -7.63e-01 | 0.3859 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0010720 | Colorectum | AD | positive regulation of cell development | 87/3918 | 298/18723 | 4.17e-04 | 4.71e-03 | 87 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
GO:0035196 | Colorectum | AD | production of miRNAs involved in gene silencing by miRNA | 20/3918 | 52/18723 | 2.87e-03 | 2.14e-02 | 20 |
GO:0031050 | Colorectum | AD | dsRNA processing | 20/3918 | 54/18723 | 4.76e-03 | 3.22e-02 | 20 |
GO:0070918 | Colorectum | AD | production of small RNA involved in gene silencing by RNA | 20/3918 | 54/18723 | 4.76e-03 | 3.22e-02 | 20 |
GO:00226181 | Colorectum | SER | ribonucleoprotein complex assembly | 69/2897 | 220/18723 | 2.25e-09 | 2.15e-07 | 69 |
GO:00718261 | Colorectum | SER | ribonucleoprotein complex subunit organization | 70/2897 | 227/18723 | 3.83e-09 | 3.51e-07 | 70 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DICER1 | SNV | Missense_Mutation | c.1144N>A | p.Glu382Lys | p.E382K | Q9UPY3 | protein_coding | tolerated(0.12) | probably_damaging(0.966) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DICER1 | deletion | Frame_Shift_Del | c.4458delN | p.Lys1486AsnfsTer4 | p.K1486Nfs*4 | Q9UPY3 | protein_coding | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |||
DICER1 | insertion | Frame_Shift_Ins | novel | c.4417_4418insT | p.Ser1473PhefsTer4 | p.S1473Ffs*4 | Q9UPY3 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DICER1 | SNV | Missense_Mutation | novel | c.5081A>G | p.Tyr1694Cys | p.Y1694C | Q9UPY3 | protein_coding | tolerated(0.08) | probably_damaging(0.995) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DICER1 | SNV | Missense_Mutation | novel | c.4807C>A | p.Leu1603Met | p.L1603M | Q9UPY3 | protein_coding | tolerated(0.23) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DICER1 | SNV | Missense_Mutation | novel | c.4157T>C | p.Val1386Ala | p.V1386A | Q9UPY3 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DICER1 | SNV | Missense_Mutation | novel | c.3940C>T | p.Arg1314Trp | p.R1314W | Q9UPY3 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DICER1 | SNV | Missense_Mutation | rs755944755 | c.896C>T | p.Ser299Leu | p.S299L | Q9UPY3 | protein_coding | deleterious(0.02) | possibly_damaging(0.727) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DICER1 | SNV | Missense_Mutation | c.5438N>G | p.Glu1813Gly | p.E1813G | Q9UPY3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DICER1 | SNV | Missense_Mutation | c.4031C>T | p.Ser1344Leu | p.S1344L | Q9UPY3 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-A5-A0GN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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