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Gene: DGCR8 |
Gene summary for DGCR8 |
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Gene information | Species | Human | Gene symbol | DGCR8 | Gene ID | 54487 |
Gene name | DGCR8 microprocessor complex subunit | |
Gene Alias | C22orf12 | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8WYQ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54487 | DGCR8 | LZE7T | Human | Esophagus | ESCC | 9.02e-06 | 3.24e-01 | 0.0667 |
54487 | DGCR8 | LZE24T | Human | Esophagus | ESCC | 6.34e-09 | 1.16e-01 | 0.0596 |
54487 | DGCR8 | P1T-E | Human | Esophagus | ESCC | 1.12e-03 | 1.57e-01 | 0.0875 |
54487 | DGCR8 | P2T-E | Human | Esophagus | ESCC | 1.02e-12 | 2.03e-01 | 0.1177 |
54487 | DGCR8 | P4T-E | Human | Esophagus | ESCC | 4.87e-10 | 1.16e-01 | 0.1323 |
54487 | DGCR8 | P5T-E | Human | Esophagus | ESCC | 8.11e-08 | 1.73e-01 | 0.1327 |
54487 | DGCR8 | P8T-E | Human | Esophagus | ESCC | 5.78e-13 | 2.11e-01 | 0.0889 |
54487 | DGCR8 | P10T-E | Human | Esophagus | ESCC | 8.87e-22 | 4.98e-01 | 0.116 |
54487 | DGCR8 | P11T-E | Human | Esophagus | ESCC | 3.54e-08 | 2.67e-01 | 0.1426 |
54487 | DGCR8 | P12T-E | Human | Esophagus | ESCC | 3.23e-09 | 1.71e-01 | 0.1122 |
54487 | DGCR8 | P15T-E | Human | Esophagus | ESCC | 2.28e-09 | 2.04e-01 | 0.1149 |
54487 | DGCR8 | P16T-E | Human | Esophagus | ESCC | 6.93e-17 | 1.63e-01 | 0.1153 |
54487 | DGCR8 | P17T-E | Human | Esophagus | ESCC | 7.27e-08 | 3.02e-01 | 0.1278 |
54487 | DGCR8 | P20T-E | Human | Esophagus | ESCC | 3.00e-03 | 1.07e-01 | 0.1124 |
54487 | DGCR8 | P21T-E | Human | Esophagus | ESCC | 5.54e-12 | 2.34e-01 | 0.1617 |
54487 | DGCR8 | P22T-E | Human | Esophagus | ESCC | 9.51e-16 | 1.47e-01 | 0.1236 |
54487 | DGCR8 | P23T-E | Human | Esophagus | ESCC | 5.32e-19 | 3.55e-01 | 0.108 |
54487 | DGCR8 | P24T-E | Human | Esophagus | ESCC | 8.32e-06 | 1.74e-01 | 0.1287 |
54487 | DGCR8 | P26T-E | Human | Esophagus | ESCC | 1.15e-10 | 1.72e-01 | 0.1276 |
54487 | DGCR8 | P27T-E | Human | Esophagus | ESCC | 6.10e-15 | 2.79e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00351969 | Esophagus | ESCC | production of miRNAs involved in gene silencing by miRNA | 37/8552 | 52/18723 | 1.75e-04 | 1.14e-03 | 37 |
GO:00310508 | Esophagus | ESCC | dsRNA processing | 38/8552 | 54/18723 | 2.08e-04 | 1.31e-03 | 38 |
GO:00709188 | Esophagus | ESCC | production of small RNA involved in gene silencing by RNA | 38/8552 | 54/18723 | 2.08e-04 | 1.31e-03 | 38 |
GO:003105311 | Esophagus | ESCC | primary miRNA processing | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DGCR8 | SNV | Missense_Mutation | novel | c.1432N>C | p.Ser478Pro | p.S478P | Q8WYQ5 | protein_coding | tolerated(0.27) | benign(0.255) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
DGCR8 | SNV | Missense_Mutation | novel | c.1505N>C | p.Glu502Ala | p.E502A | Q8WYQ5 | protein_coding | deleterious(0.02) | possibly_damaging(0.862) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
DGCR8 | insertion | In_Frame_Ins | rs771572387 | c.1507_1508insTACCAGAGAAACAAA | p.Phe503delinsLeuProGluLysGlnIle | p.F503delinsLPEKQI | Q8WYQ5 | protein_coding | TCGA-AX-A05W-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DGCR8 | insertion | Frame_Shift_Ins | rs772862570 | c.1508_1509insACCAGAGAAACAAA | p.Phe503LeufsTer49 | p.F503Lfs*49 | Q8WYQ5 | protein_coding | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | ||
DGCR8 | insertion | Frame_Shift_Ins | novel | c.774dupC | p.Lys259GlnfsTer31 | p.K259Qfs*31 | Q8WYQ5 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
DGCR8 | SNV | Missense_Mutation | novel | c.1936G>T | p.Gly646Trp | p.G646W | Q8WYQ5 | protein_coding | tolerated(0.08) | probably_damaging(0.999) | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DGCR8 | SNV | Missense_Mutation | novel | c.914A>T | p.Asp305Val | p.D305V | Q8WYQ5 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DGCR8 | SNV | Missense_Mutation | c.1180N>A | p.Glu394Lys | p.E394K | Q8WYQ5 | protein_coding | tolerated(0.09) | benign(0) | TCGA-86-8278-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | etoposide | SD | |
DGCR8 | SNV | Missense_Mutation | c.1596N>G | p.Phe532Leu | p.F532L | Q8WYQ5 | protein_coding | deleterious(0) | possibly_damaging(0.743) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DGCR8 | SNV | Missense_Mutation | c.106N>T | p.Pro36Ser | p.P36S | Q8WYQ5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-93-A4JO-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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