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Gene: DDX41 |
Gene summary for DDX41 |
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Gene information | Species | Human | Gene symbol | DDX41 | Gene ID | 51428 |
Gene name | DEAD-box helicase 41 | |
Gene Alias | ABS | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | B3KRK2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51428 | DDX41 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.61e-05 | 1.44e-01 | 0.0155 |
51428 | DDX41 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.74e-07 | 2.26e-01 | -0.1954 |
51428 | DDX41 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.83e-03 | 1.83e-01 | -0.1526 |
51428 | DDX41 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.52e-12 | 3.02e-01 | -0.1464 |
51428 | DDX41 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.93e-03 | 1.42e-01 | -0.1001 |
51428 | DDX41 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.55e-06 | 2.91e-01 | -0.059 |
51428 | DDX41 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.95e-03 | 2.75e-01 | -0.1706 |
51428 | DDX41 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.28e-02 | 2.55e-01 | -0.0842 |
51428 | DDX41 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.82e-05 | 1.82e-01 | 0.096 |
51428 | DDX41 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.63e-02 | 3.28e-01 | 0.0446 |
51428 | DDX41 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.60e-05 | 1.57e-01 | 0.0674 |
51428 | DDX41 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.09e-04 | 1.18e-01 | 0.294 |
51428 | DDX41 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.18e-02 | 5.01e-01 | 0.3487 |
51428 | DDX41 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.23e-14 | 3.15e-01 | 0.3859 |
51428 | DDX41 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.72e-05 | 1.82e-01 | 0.3005 |
51428 | DDX41 | LZE4T | Human | Esophagus | ESCC | 2.37e-04 | 1.51e-01 | 0.0811 |
51428 | DDX41 | LZE7T | Human | Esophagus | ESCC | 2.22e-05 | 2.20e-01 | 0.0667 |
51428 | DDX41 | LZE8T | Human | Esophagus | ESCC | 1.79e-03 | 1.20e-01 | 0.067 |
51428 | DDX41 | LZE20T | Human | Esophagus | ESCC | 1.98e-04 | 1.16e-01 | 0.0662 |
51428 | DDX41 | LZE24T | Human | Esophagus | ESCC | 2.71e-19 | 3.81e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00003751 | Colorectum | SER | RNA splicing, via transesterification reactions | 90/2897 | 324/18723 | 8.68e-09 | 7.50e-07 | 90 |
GO:00003771 | Colorectum | SER | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00003981 | Colorectum | SER | mRNA splicing, via spliceosome | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:00083803 | Colorectum | MSI-H | RNA splicing | 82/1319 | 434/18723 | 1.22e-16 | 4.53e-14 | 82 |
GO:00003753 | Colorectum | MSI-H | RNA splicing, via transesterification reactions | 67/1319 | 324/18723 | 7.99e-16 | 2.61e-13 | 67 |
GO:00003773 | Colorectum | MSI-H | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
GO:00003983 | Colorectum | MSI-H | mRNA splicing, via spliceosome | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX41 | SNV | Missense_Mutation | novel | c.859G>T | p.Asp287Tyr | p.D287Y | Q9UJV9 | protein_coding | tolerated(0.26) | benign(0.062) | TCGA-CQ-6219-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DDX41 | SNV | Missense_Mutation | novel | c.1319A>G | p.Glu440Gly | p.E440G | Q9UJV9 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-CV-7407-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX41 | SNV | Missense_Mutation | novel | c.13N>C | p.Glu5Gln | p.E5Q | Q9UJV9 | protein_coding | tolerated_low_confidence(0.29) | benign(0.055) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DDX41 | SNV | Missense_Mutation | novel | c.594N>C | p.Lys198Asn | p.K198N | Q9UJV9 | protein_coding | tolerated(0.18) | benign(0.022) | TCGA-P3-A6T7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
DDX41 | SNV | Missense_Mutation | novel | c.301N>T | p.Arg101Cys | p.R101C | Q9UJV9 | protein_coding | deleterious(0.05) | possibly_damaging(0.528) | TCGA-V1-A9OF-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD |
DDX41 | SNV | Missense_Mutation | novel | c.1527N>A | p.Met509Ile | p.M509I | Q9UJV9 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DDX41 | SNV | Missense_Mutation | novel | c.299N>T | p.Ala100Val | p.A100V | Q9UJV9 | protein_coding | tolerated(0.28) | benign(0.007) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DDX41 | SNV | Missense_Mutation | novel | c.631N>A | p.Gly211Ser | p.G211S | Q9UJV9 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-YL-A8HJ-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | casodex | CR |
DDX41 | SNV | Missense_Mutation | c.390G>T | p.Lys130Asn | p.K130N | Q9UJV9 | protein_coding | tolerated(0.36) | benign(0.131) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DDX41 | SNV | Missense_Mutation | c.1226T>G | p.Ile409Ser | p.I409S | Q9UJV9 | protein_coding | deleterious(0.02) | benign(0.168) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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