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Gene: CYTIP |
Gene summary for CYTIP |
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Gene information | Species | Human | Gene symbol | CYTIP | Gene ID | 9595 |
Gene name | cytohesin 1 interacting protein | |
Gene Alias | B3-1 | |
Cytomap | 2q24.1 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | O60759 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9595 | CYTIP | LZE4T | Human | Esophagus | ESCC | 3.04e-04 | 4.56e-01 | 0.0811 |
9595 | CYTIP | LZE7T | Human | Esophagus | ESCC | 3.87e-07 | 9.33e-01 | 0.0667 |
9595 | CYTIP | LZE6T | Human | Esophagus | ESCC | 6.84e-21 | 1.51e+00 | 0.0845 |
9595 | CYTIP | C21 | Human | Oral cavity | OSCC | 2.04e-11 | 4.38e-01 | 0.2678 |
9595 | CYTIP | C30 | Human | Oral cavity | OSCC | 4.10e-03 | 2.38e-01 | 0.3055 |
9595 | CYTIP | C38 | Human | Oral cavity | OSCC | 1.24e-05 | 9.14e-01 | 0.172 |
9595 | CYTIP | C06 | Human | Oral cavity | OSCC | 1.96e-02 | 4.12e-01 | 0.2699 |
9595 | CYTIP | C08 | Human | Oral cavity | OSCC | 1.67e-03 | 5.92e-02 | 0.1919 |
9595 | CYTIP | C09 | Human | Oral cavity | OSCC | 4.94e-04 | 1.62e-01 | 0.1431 |
9595 | CYTIP | LN22 | Human | Oral cavity | OSCC | 6.36e-08 | 9.34e-01 | 0.1733 |
9595 | CYTIP | EOLP-1 | Human | Oral cavity | EOLP | 9.17e-12 | 5.59e-01 | -0.0202 |
9595 | CYTIP | SYSMH6 | Human | Oral cavity | OSCC | 1.45e-02 | 4.98e-02 | 0.1275 |
9595 | CYTIP | 047563_1562-all-cells | Human | Prostate | BPH | 2.20e-11 | 4.24e-01 | 0.0791 |
9595 | CYTIP | 052095_1628-all-cells | Human | Prostate | BPH | 2.27e-04 | 1.73e-01 | 0.1032 |
9595 | CYTIP | Dong_P1 | Human | Prostate | Tumor | 1.13e-06 | 1.01e-01 | 0.035 |
9595 | CYTIP | Dong_P3 | Human | Prostate | Tumor | 2.88e-02 | 7.86e-02 | 0.0278 |
9595 | CYTIP | Dong_P5 | Human | Prostate | Tumor | 2.03e-02 | 5.31e-02 | 0.053 |
9595 | CYTIP | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 6.49e-08 | 8.07e-01 | 0.1479 |
9595 | CYTIP | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 2.22e-03 | 5.20e-01 | 0.1531 |
9595 | CYTIP | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.53e-03 | 3.06e-01 | 0.1633 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYTIP | SNV | Missense_Mutation | novel | c.58N>T | p.Ala20Ser | p.A20S | O60759 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-F7-A50I-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CYTIP | SNV | Missense_Mutation | c.907C>T | p.Arg303Trp | p.R303W | O60759 | protein_coding | deleterious(0.01) | probably_damaging(0.952) | TCGA-EJ-7115-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | |
CYTIP | SNV | Missense_Mutation | rs202198683 | c.989N>A | p.Arg330Gln | p.R330Q | O60759 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EJ-A7NN-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD |
CYTIP | SNV | Missense_Mutation | rs758705411 | c.1073N>A | p.Arg358His | p.R358H | O60759 | protein_coding | tolerated(0.13) | probably_damaging(0.987) | TCGA-HC-7749-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
CYTIP | SNV | Missense_Mutation | novel | c.266N>A | p.Gly89Glu | p.G89E | O60759 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CYTIP | SNV | Missense_Mutation | c.161G>T | p.Arg54Leu | p.R54L | O60759 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CYTIP | SNV | Missense_Mutation | rs748002457 | c.730A>C | p.Ser244Arg | p.S244R | O60759 | protein_coding | deleterious(0.03) | probably_damaging(0.963) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CYTIP | SNV | Missense_Mutation | c.440N>G | p.Val147Gly | p.V147G | O60759 | protein_coding | deleterious(0) | possibly_damaging(0.756) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CYTIP | SNV | Missense_Mutation | c.832N>G | p.Thr278Ala | p.T278A | O60759 | protein_coding | tolerated(0.31) | benign(0.025) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
CYTIP | SNV | Missense_Mutation | rs758705411 | c.1073N>A | p.Arg358His | p.R358H | O60759 | protein_coding | tolerated(0.13) | probably_damaging(0.987) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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