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Gene: CYSLTR2 |
Gene summary for CYSLTR2 |
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Gene information | Species | Human | Gene symbol | CYSLTR2 | Gene ID | 57105 |
Gene name | cysteinyl leukotriene receptor 2 | |
Gene Alias | CYSLT2 | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | A4ZKH2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57105 | CYSLTR2 | male-WTA | Human | Thyroid | PTC | 6.16e-27 | 4.15e-01 | 0.1037 |
57105 | CYSLTR2 | PTC01 | Human | Thyroid | PTC | 5.45e-11 | 2.58e-01 | 0.1899 |
57105 | CYSLTR2 | PTC04 | Human | Thyroid | PTC | 2.61e-10 | 2.24e-01 | 0.1927 |
57105 | CYSLTR2 | PTC05 | Human | Thyroid | PTC | 4.06e-13 | 6.44e-01 | 0.2065 |
57105 | CYSLTR2 | PTC06 | Human | Thyroid | PTC | 1.08e-30 | 7.32e-01 | 0.2057 |
57105 | CYSLTR2 | PTC07 | Human | Thyroid | PTC | 7.40e-31 | 6.08e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1901653111 | Thyroid | PTC | cellular response to peptide | 169/5968 | 359/18723 | 9.81e-10 | 2.89e-08 | 169 |
GO:0043434113 | Thyroid | PTC | response to peptide hormone | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
GO:0071375110 | Thyroid | PTC | cellular response to peptide hormone stimulus | 136/5968 | 290/18723 | 5.49e-08 | 1.17e-06 | 136 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYSLTR2 | insertion | Frame_Shift_Ins | novel | c.412_413insT | p.Ala139GlyfsTer41 | p.A139Gfs*41 | Q9NS75 | protein_coding | TCGA-D6-A6EK-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PR | ||
CYSLTR2 | SNV | Missense_Mutation | c.391N>C | p.Val131Leu | p.V131L | Q9NS75 | protein_coding | tolerated(0.06) | benign(0.028) | TCGA-HC-8265-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
CYSLTR2 | SNV | Missense_Mutation | rs749662416 | c.676N>T | p.Arg226Trp | p.R226W | Q9NS75 | protein_coding | deleterious(0.05) | possibly_damaging(0.461) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
CYSLTR2 | SNV | Missense_Mutation | novel | c.1034N>A | p.Arg345Lys | p.R345K | Q9NS75 | protein_coding | tolerated_low_confidence(0.66) | benign(0) | TCGA-BJ-A45E-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYSLTR2 | SNV | Missense_Mutation | c.776G>A | p.Cys259Tyr | p.C259Y | Q9NS75 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-ET-A2N4-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CYSLTR2 | insertion | Frame_Shift_Ins | novel | c.1031_1032insACAAG | p.Arg345GlnfsTer24 | p.R345Qfs*24 | Q9NS75 | protein_coding | TCGA-EL-A3ZP-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CYSLTR2 | insertion | Frame_Shift_Ins | novel | c.189_190insTCTCCATG | p.Leu64SerfsTer13 | p.L64Sfs*13 | Q9NS75 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651514 | ||
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178100365 | POBILUKAST | |
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178102817 | ||
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178100355 | ZAFIRLUKAST | |
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 178100418 | ||
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178102818 | ||
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178102485 | IRALUKAST | |
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 404859029 | ||
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 404859027 | ||
57105 | CYSLTR2 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651513 |
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