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Gene: CYP20A1 |
Gene summary for CYP20A1 |
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Gene information | Species | Human | Gene symbol | CYP20A1 | Gene ID | 57404 |
Gene name | cytochrome P450 family 20 subfamily A member 1 | |
Gene Alias | CYP-M | |
Cytomap | 2q33.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6UW02 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57404 | CYP20A1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.03e-03 | 2.92e-01 | -0.0811 |
57404 | CYP20A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.96e-16 | 6.35e-01 | -0.1954 |
57404 | CYP20A1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.45e-04 | 4.01e-01 | -0.1526 |
57404 | CYP20A1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.61e-03 | 3.97e-01 | -0.1464 |
57404 | CYP20A1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.04e-02 | 3.20e-01 | -0.1001 |
57404 | CYP20A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.73e-06 | 3.78e-01 | -0.059 |
57404 | CYP20A1 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.42e-03 | 4.76e-01 | -0.0842 |
57404 | CYP20A1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.85e-03 | 2.43e-01 | 0.0338 |
57404 | CYP20A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.28e-02 | 3.07e-01 | 0.0674 |
57404 | CYP20A1 | A015-C-203 | Human | Colorectum | FAP | 3.67e-10 | -1.67e-01 | -0.1294 |
57404 | CYP20A1 | A002-C-201 | Human | Colorectum | FAP | 4.68e-02 | -1.89e-01 | 0.0324 |
57404 | CYP20A1 | A001-C-108 | Human | Colorectum | FAP | 3.45e-03 | -1.95e-02 | -0.0272 |
57404 | CYP20A1 | A002-C-205 | Human | Colorectum | FAP | 1.23e-03 | -5.58e-02 | -0.1236 |
57404 | CYP20A1 | A015-C-006 | Human | Colorectum | FAP | 5.70e-03 | -1.95e-01 | -0.0994 |
57404 | CYP20A1 | A002-C-114 | Human | Colorectum | FAP | 1.69e-03 | -1.73e-01 | -0.1561 |
57404 | CYP20A1 | A015-C-104 | Human | Colorectum | FAP | 1.57e-08 | -1.09e-01 | -0.1899 |
57404 | CYP20A1 | A001-C-014 | Human | Colorectum | FAP | 1.32e-02 | -1.08e-01 | 0.0135 |
57404 | CYP20A1 | A002-C-016 | Human | Colorectum | FAP | 1.54e-05 | -1.47e-01 | 0.0521 |
57404 | CYP20A1 | A002-C-116 | Human | Colorectum | FAP | 9.37e-09 | -4.90e-02 | -0.0452 |
57404 | CYP20A1 | A018-E-020 | Human | Colorectum | FAP | 5.03e-03 | -1.48e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYP20A1 | SNV | Missense_Mutation | novel | c.411T>A | p.Ser137Arg | p.S137R | Q6UW02 | protein_coding | tolerated(0.19) | benign(0.037) | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CYP20A1 | insertion | Frame_Shift_Ins | novel | c.412_413insCAAGAGATCAGGG | p.Asn138ThrfsTer19 | p.N138Tfs*19 | Q6UW02 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CYP20A1 | insertion | Frame_Shift_Ins | novel | c.970_971insTGGCTTG | p.Arg324MetfsTer11 | p.R324Mfs*11 | Q6UW02 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57404 | CYP20A1 | CYTOCHROME P450, DRUGGABLE GENOME, ENZYME | MBC | 9347928 |
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