![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CSGALNACT2 |
Gene summary for CSGALNACT2 |
![]() |
Gene information | Species | Human | Gene symbol | CSGALNACT2 | Gene ID | 55454 |
Gene name | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | |
Gene Alias | CHGN2 | |
Cytomap | 10q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | A0A0S2Z5K4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55454 | CSGALNACT2 | C04 | Human | Oral cavity | OSCC | 3.98e-08 | 4.28e-01 | 0.2633 |
55454 | CSGALNACT2 | C21 | Human | Oral cavity | OSCC | 1.19e-10 | 4.22e-01 | 0.2678 |
55454 | CSGALNACT2 | C30 | Human | Oral cavity | OSCC | 9.57e-12 | 6.12e-01 | 0.3055 |
55454 | CSGALNACT2 | C43 | Human | Oral cavity | OSCC | 3.30e-05 | 5.01e-02 | 0.1704 |
55454 | CSGALNACT2 | C46 | Human | Oral cavity | OSCC | 2.14e-03 | 7.46e-02 | 0.1673 |
55454 | CSGALNACT2 | C51 | Human | Oral cavity | OSCC | 1.20e-06 | 2.33e-01 | 0.2674 |
55454 | CSGALNACT2 | C06 | Human | Oral cavity | OSCC | 2.84e-04 | 6.61e-01 | 0.2699 |
55454 | CSGALNACT2 | C08 | Human | Oral cavity | OSCC | 1.33e-06 | 2.39e-01 | 0.1919 |
55454 | CSGALNACT2 | EOLP-1 | Human | Oral cavity | EOLP | 7.12e-19 | 4.63e-01 | -0.0202 |
55454 | CSGALNACT2 | EOLP-2 | Human | Oral cavity | EOLP | 3.65e-06 | 2.86e-01 | -0.0203 |
55454 | CSGALNACT2 | NEOLP-1 | Human | Oral cavity | NEOLP | 3.90e-09 | 3.52e-01 | -0.0194 |
55454 | CSGALNACT2 | NEOLP-2 | Human | Oral cavity | NEOLP | 1.31e-05 | 2.31e-01 | -0.0196 |
55454 | CSGALNACT2 | NEOLP-3 | Human | Oral cavity | NEOLP | 3.74e-13 | 3.39e-01 | -0.0191 |
55454 | CSGALNACT2 | SYSMH1 | Human | Oral cavity | OSCC | 4.21e-03 | 1.54e-01 | 0.1127 |
55454 | CSGALNACT2 | SYSMH2 | Human | Oral cavity | OSCC | 2.49e-04 | 1.09e-01 | 0.2326 |
55454 | CSGALNACT2 | SYSMH3 | Human | Oral cavity | OSCC | 1.02e-06 | 1.66e-01 | 0.2442 |
55454 | CSGALNACT2 | male-WTA | Human | Thyroid | PTC | 7.17e-10 | 8.88e-02 | 0.1037 |
55454 | CSGALNACT2 | PTC01 | Human | Thyroid | PTC | 9.63e-04 | 6.05e-02 | 0.1899 |
55454 | CSGALNACT2 | PTC04 | Human | Thyroid | PTC | 3.30e-17 | 3.09e-01 | 0.1927 |
55454 | CSGALNACT2 | PTC05 | Human | Thyroid | PTC | 2.13e-08 | 5.35e-01 | 0.2065 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00442724 | Oral cavity | OSCC | sulfur compound biosynthetic process | 82/7305 | 148/18723 | 3.71e-05 | 3.31e-04 | 82 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:0030206 | Oral cavity | OSCC | chondroitin sulfate biosynthetic process | 15/7305 | 18/18723 | 1.53e-04 | 1.07e-03 | 15 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091011 | Oral cavity | OSCC | glycoprotein biosynthetic process | 151/7305 | 317/18723 | 1.01e-03 | 5.26e-03 | 151 |
GO:0050650 | Oral cavity | OSCC | chondroitin sulfate proteoglycan biosynthetic process | 16/7305 | 23/18723 | 2.93e-03 | 1.27e-02 | 16 |
GO:00160513 | Oral cavity | OSCC | carbohydrate biosynthetic process | 97/7305 | 202/18723 | 5.50e-03 | 2.13e-02 | 97 |
GO:0030204 | Oral cavity | OSCC | chondroitin sulfate metabolic process | 19/7305 | 30/18723 | 6.03e-03 | 2.28e-02 | 19 |
GO:00442625 | Oral cavity | OSCC | cellular carbohydrate metabolic process | 130/7305 | 283/18723 | 9.98e-03 | 3.49e-02 | 130 |
GO:00442726 | Thyroid | PTC | sulfur compound biosynthetic process | 63/5968 | 148/18723 | 3.91e-03 | 1.87e-02 | 63 |
GO:00091013 | Thyroid | PTC | glycoprotein biosynthetic process | 123/5968 | 317/18723 | 5.05e-03 | 2.33e-02 | 123 |
GO:00091003 | Thyroid | PTC | glycoprotein metabolic process | 147/5968 | 387/18723 | 5.87e-03 | 2.64e-02 | 147 |
GO:004427212 | Thyroid | ATC | sulfur compound biosynthetic process | 66/6293 | 148/18723 | 3.43e-03 | 1.53e-02 | 66 |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00532 | Oral cavity | OSCC | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 16/3704 | 21/8465 | 2.61e-03 | 6.77e-03 | 3.45e-03 | 16 |
hsa005321 | Oral cavity | OSCC | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 16/3704 | 21/8465 | 2.61e-03 | 6.77e-03 | 3.45e-03 | 16 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSGALNACT2 | SNV | Missense_Mutation | novel | c.1079A>C | p.Glu360Ala | p.E360A | Q8N6G5 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CSGALNACT2 | SNV | Missense_Mutation | novel | c.790N>G | p.Met264Val | p.M264V | Q8N6G5 | protein_coding | tolerated(0.3) | benign(0) | TCGA-56-8625-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
CSGALNACT2 | SNV | Missense_Mutation | novel | c.1219N>G | p.Asn407Asp | p.N407D | Q8N6G5 | protein_coding | tolerated(0.65) | benign(0.171) | TCGA-63-7022-01 | Lung | lung squamous cell carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CSGALNACT2 | SNV | Missense_Mutation | novel | c.32G>C | p.Arg11Pro | p.R11P | Q8N6G5 | protein_coding | tolerated(0.22) | probably_damaging(0.995) | TCGA-77-8131-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CSGALNACT2 | SNV | Missense_Mutation | c.636A>G | p.Ile212Met | p.I212M | Q8N6G5 | protein_coding | tolerated(0.08) | benign(0.009) | TCGA-NC-A5HE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
CSGALNACT2 | SNV | Missense_Mutation | novel | c.1071C>A | p.Asp357Glu | p.D357E | Q8N6G5 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-NC-A5HG-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR |
CSGALNACT2 | insertion | Nonsense_Mutation | novel | c.620_621insATGCTAACTTCAGC | p.Gly208CysfsTer2 | p.G208Cfs*2 | Q8N6G5 | protein_coding | TCGA-44-A47B-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CSGALNACT2 | SNV | Missense_Mutation | novel | c.394G>C | p.Glu132Gln | p.E132Q | Q8N6G5 | protein_coding | deleterious(0) | possibly_damaging(0.843) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CSGALNACT2 | SNV | Missense_Mutation | novel | c.755N>T | p.Arg252Leu | p.R252L | Q8N6G5 | protein_coding | deleterious(0) | possibly_damaging(0.506) | TCGA-CR-7371-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CSGALNACT2 | SNV | Missense_Mutation | novel | c.134N>T | p.Pro45Leu | p.P45L | Q8N6G5 | protein_coding | tolerated(0.33) | probably_damaging(0.997) | TCGA-CR-7382-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |